The role of retinal regulation of sleep in health and disease

Schmoll, Conrad; Lascaratos, Gerassimos; Dhillon, Baljean; Skene, Debra J.; Riha, Renata L.

doi:10.1016/j.smrv.2010.06.001

Cited by 28 publications

(19 citation statements)

References 95 publications

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“…A subset of retinal ganglion cells, known as melanopsin photoreceptors, are believed to play a role in regulating circadian rhythms. Dysfunction of these retinal ganglion cells, possibly by α-synuclein deposition, or by a change in dopamine levels, causes unopposed melatonin production, with subsequent effects on sleep (for a review see Schmoll et al , 2011). Furthermore, the projection of these cells to brain regions involved in circadian and sleep functions as well as to visual areas such as the lateral geniculate nucleus may explain some of the daytime-dependent (not just luminance-dependent) visual symptoms of Parkinson’s disease (La Morgia et al , 2011).…”

Section: Clinical Relevancementioning

confidence: 99%

Visual dysfunction in Parkinson’s disease

Weil

Schrag

Warren

et al. 2016

Brain

343

285

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Section: Clinical Relevancementioning

confidence: 99%

Visual dysfunction in Parkinson’s disease

Weil

Schrag

Warren

et al. 2016

Brain

343

285

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“…16,17 Indeed, the rate of circadian-related sleepwake disorders is likely to be higher among visually impaired individuals without LP than among those with LP.…”

Section: -10mentioning

confidence: 99%

“…[11][12][13][14][15] Reportedly, especially in people without light perception (LP), inhibited transmission of light signals to the suprachiasmatic nuclei might cause sleeprelated problems because of external desynchronization of the biological clock. 16,17 Indeed, the rate of circadian-related sleepwake disorders is likely to be higher among visually impaired individuals without LP than among those with LP. 12 In Japan, no large nationwide study of this subject has ever been reported.…”

Section: Introductionmentioning

confidence: 99%

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Tamura

Sasai-Sakuma

Morita

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: This questionnaire-based cross-sectional study was conducted (1) to estimate the prevalence of sleep-related problems, and (2) to explore factors associated with lower physical/mental quality of life (QOL), particularly addressing sleep-related problems among Japanese visually impaired people. Methods: This nationwide questionnaire-based survey was administered to visually impaired individuals through the Japan Federation of the Blind. Visually impaired individuals without light perception (LP) (n = 311), those with LP (n = 287), and age-matched and gender-matched controls (n = 615) were eligible for this study. Study questionnaires elicited demographic information, and information about visual impairment status, sleep-related problems, and health-related quality of life. Results: Visually impaired individuals with and without LP showed higher prevalence rates of irregular sleep-wake patterns and difficulty maintaining sleep than controls (34.7% and 29.4% vs. 15.8%, 60.1% and 46.7% vs. 26.8%, respectively; p < 0.001). These sleep-related problems were observed more frequently in visually impaired individuals without LP than in those with LP. Non-restorative sleep or excessive daytime sleepiness was associated with lower mental/physical QOL in visually impaired individuals with LP and in control subjects. However, visually impaired individuals without LP showed irregular sleepwake pattern or difficulty waking up at the desired time, which was associated with lower mental/physical QOL. Conclusions: Sleep-related problems were observed more frequently in visually impaired individuals than in controls. Moreover, the rates of difficulties were higher among subjects without LP. Sleep-related problems, especially circadian rhythm-related ones, can be associated with lower mental/physical QOL in visually impaired individuals without LP. Keywords: circadian rhythm sleep-wake disorder, health-related quality of life, light perception, prevalence, sleep-related problems, visual impairment I NTRO DUCTI O NVisually impaired individuals are likely to have any of several comorbid mental/physical disorders including diabetes mellitus, hypertension, cognitive impairment, and depression/ anxiety. [1][2][3][4][5][6] The severity of these mental/physical disorders is reportedly correlated with visual impairment.1-9 Therefore, those individuals might be at risk for lower health-related quality of life (QOL). 7-10Sleep-related problems have been observed frequently in visually impaired individuals.11-15 Reportedly, especially in people without light perception (LP), inhibited transmission of light signals to the suprachiasmatic nuclei might cause sleeprelated problems because of external desynchronization of the biological clock. 16,17 Indeed, the rate of circadian-related sleepwake disorders is likely to be higher among visually impaired individuals without LP than among those with LP.12 In Japan, no large nationwide study of this subject has ever been reported. The actual prevalence of sleep-related problems amon...

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“…Removal of a yellow opaque crystalline lens and replacement with a clear intraocular lens (IOL) as a means of increasing blue-light transmission thus has potential benefits to non-visual melanopsin-dependant brain responses, the human circadian rhythm and its downstream physiological effects 9 10…”

Section: Introductionmentioning

confidence: 99%