Reaction time as a measure of enhanced blue-light mediated cognitive function following cataract surgery

Schmoll, Conrad; Tendo, Christelle; Aspinall, Peter; Dhillon, Baljean

doi:10.1136/bjophthalmol-2011-300677

Cited by 21 publications

(17 citation statements)

References 15 publications

(18 reference statements)

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“…A faster reaction time was associated with a thinner RNFL thickness (p < 0.001) and this stayed significant in the multivariable model for average RNFL (p = 0.01), and for the inferior and temporal quadrants (p = 0.01 and p = 0.04 respectively). As cataract surgery has been reported to improve reaction times 10 , we compared the reaction time in the 63 pseudophakic participants to that of 126 age-matched individuals without cataract surgery (case:control ratio of 1:2). There was no difference between the two groups (mean of 630 ms and 632 ms respectively, p = 0.8).…”

Section: Resultsmentioning

confidence: 99%

The correlation between cognitive performance and retinal nerve fibre layer thickness is largely explained by genetic factors

Jones-Odeh

Yonova-Doing

Bloch

et al. 2016

Sci Rep

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Retinal nerve fibre layer (RNFL) thickness has been associated with cognitive function but it is unclear whether RNFL thinning is secondary to cortical loss, or if the same disease process affects both. We explored whether there is phenotypic sharing between RNFL thickness and cognitive traits, and whether such sharing is due to genetic factors. Detailed eye and cognitive examination were performed on 1602 twins (mean age: 56.4 years; range: 18–89) from the TwinsUK cohort. Associations between RNFL thickness and ophthalmic, cognitive and other predictors were assessed using linear regression or analysis of variance models. Heritability analyses were performed using uni- and bivariate Cholesky decomposition models. RNFL was thinner with increase in myopia and with decrease in disc area (p < 0.001). A thicker RNFL was associated with better performance on mini mental state examination (MMSE, F(5,883) = 5.8, p < 0.001), and with faster reaction time (RT, β = −0.01; p = 0.01); independent of the effects of age, refractive error and disc area (p < 0.05). RNFL thickness was highly heritable (82%) but there was low phenotypic sharing between RNFL thickness and MMSE (5%, 95% CI: 0–10%) or RT (7%, 95% CI: 1–12%). This sharing, however, was mostly due to additive genetic effects (67% and 92% of the shared variance respectively).

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Section: Resultsmentioning

confidence: 99%

The correlation between cognitive performance and retinal nerve fibre layer thickness is largely explained by genetic factors

Jones-Odeh

Yonova-Doing

Bloch

et al. 2016

Sci Rep

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“…Although we do not exclude that aged subjects with sleep and circadian alterations, or with cataract, might have a decreased non-visual sensitivity to light, there is no clinical evidence that healthy older individuals have a decreased non-visual sensitivity to light. Indeed, it has been reported that only half of cataract patients suffer from poor sleep, and that increased light transmission after cataract surgery [47] improves sleep quality [80] and decreases psychomotor reaction time [81]. On the other hand, patients with normal sleep quality show no difference in their sleep following cataract surgery [80], nor in their melatonin secretion, sleep parameters or sleepiness [82].…”

Section: Discussionmentioning

confidence: 99%

Aging of Non-Visual Spectral Sensitivity to Light in Humans: Compensatory Mechanisms?

et al. 2014

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The deterioration of sleep in the older population is a prevalent feature that contributes to a decrease in quality of life. Inappropriate entrainment of the circadian clock by light is considered to contribute to the alteration of sleep structure and circadian rhythms in the elderly. The present study investigates the effects of aging on non-visual spectral sensitivity to light and tests the hypothesis that circadian disturbances are related to a decreased light transmittance. In a within-subject design, eight aged and five young subjects were exposed at night to 60 minute monochromatic light stimulations at 9 different wavelengths (420–620 nm). Individual sensitivity spectra were derived from measures of melatonin suppression. Lens density was assessed using a validated psychophysical technique. Although lens transmittance was decreased for short wavelength light in the older participants, melatonin suppression was not reduced. Peak of non-visual sensitivity was, however, shifted to longer wavelengths in the aged participants (494 nm) compared to young (484 nm). Our results indicate that increased lens filtering does not necessarily lead to a decreased non-visual sensitivity to light. The lack of age-related decrease in non-visual sensitivity to light may involve as yet undefined adaptive mechanisms.

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“…The RT task is performed on a validated purpose-built electronic device of the kind first used in the Health and Lifestyle Study18 and recently used in the pilot study 8. The participant is tested at a desktop under standard illumination and given standardised instructions for performing the test by a masked researcher.…”

Section: Methodsmentioning

confidence: 99%

New light for old eyes: comparing melanopsin-mediated non-visual benefits of blue-light and UV-blocking intraocular lenses

et al. 2013

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Reaction time as a measure of enhanced blue-light mediated cognitive function following cataract surgery

Abstract: The results suggest that improved blue-light transmission following cataract surgery has a beneficial effect on cognitive function. We advocate the RTT as an objective platform for exploring these benefits in large sample randomised controlled trials.

Cited by 21 publications

References 15 publications

The correlation between cognitive performance and retinal nerve fibre layer thickness is largely explained by genetic factors

The correlation between cognitive performance and retinal nerve fibre layer thickness is largely explained by genetic factors

Aging of Non-Visual Spectral Sensitivity to Light in Humans: Compensatory Mechanisms?

New light for old eyes: comparing melanopsin-mediated non-visual benefits of blue-light and UV-blocking intraocular lenses

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