The role of resveratrol on mast cell and chymase and tryptase expression in blunt-chest-trauma-induced acute lung injury in rats

Tütüncü, Şerife; Torun, Aysun Çağlar; Ertuğrul, Tuğrul

doi:10.3906/vet-2005-23

Cited by 1 publication

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“…In embryonic and newborn mouse spleen tissue, it has been demonstrated by studies that the number of AB (+) mast cells increases with the developmental process (4). Studies have reported that mast cell heterogeneity changes depending on hormonal effects (13), exposure to formaldehyde (14), and the administration of active ingredients such as capsaicin (44) and resveratrol (45). In our study, we found three subtypes of mast cells with SO (+), AB (+) and AB/ SO (+) staining in all experiment and control groups.…”

Section: M M U N O H I S T O C H E M I C a L F I N D I N G S C H Y M A S Epositive Mast Cellssupporting

confidence: 66%

“…Cell count was performed at 10 different, randomly selected areas of the sections taken from the spleens, and the arithmetic mean of the results was taken. All data obtained by calculating the square of 100-square ocular micrometer for × 40 lens magnification with the help of a micrometric slide were turned into mast cell numbers within a unit area of 1 mm 2 (45). The SPSS program was used in the comparison of the mast cell counts between the groups, and one-way ANOVA was conducted (16).…”

Section: Methodsmentioning

confidence: 99%

“…It was stated that CTMC was stained as SO (+) (12), while MMC was stained with AB (+) in the AB/SO combined staining method (14). The researchers reported that three kinds of mast cells were found to be Alcian bluepositive, pink-red color safranin-positive, and red-blue color AB/SO (+) when the AB/SO staining method was used (45). In embryonic and newborn mouse spleen tissue, it has been demonstrated by studies that the number of AB (+) mast cells increases with the developmental process (4).…”

Section: M M U N O H I S T O C H E M I C a L F I N D I N G S C H Y M A S Epositive Mast Cellsmentioning

confidence: 99%

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Possible effect of thymoquinone on mast cell number and chymase, IL-4, IFN-γ expression in rat spleen

Ertuğrul¹,

Tütüncü²,

Ozdemir³

et al. 2021

Medycyna Weterynaryjna

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Thymoquinone (TQ) has been widely used in traditional medicine for the treatment of many diseases, to support the circulatory and immune system and to protect general health. Moreover, it is used as a nutritional supplement for preventive and therapeutic purposes in the respiratory, digestive and urinary systems. Secretion granules in the cytoplasm of mast cells contain primary mediators such as histamine, neutral proteases such as tryptase and chymase, and cytokines such as interleukin-4 (IL-4) and interferon-gamma (IFN-γ). 35 Sprague Dawley adult female rats were used as the study material. The rats were randomly assigned to five groups. First group: 1 ml/kg dose and second group: 2 ml/kg dose of TQ prepared at 1/1 (v/v) of ethanol and saline was intraperitoneally injected regularly in the rats daily for 42 days. Third group: 10 mg/kg dose and fourth group: 20 mg/kg dose of TQ was administered orally with the aid of a gavage probe. Fifth group was the control group in which no intervention was made. The lowest number of mast cells was detected in the group administered TQ at a dose of 20 mg/kg by oral gavage. It was determined that the numbers of mast cells in the control group and the group treated with TQ at a dose of 1 ml/kg intraperitoneally were close to each other. It was concluded that the increase or decrease between groups in the distribution of mast cells, chymase, IL-4, and IFN-γ cytokine expression may be partially effected in the spleen tissue by substances such as TQ.

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Section: M M U N O H I S T O C H E M I C a L F I N D I N G S C H Y M A S Epositive Mast Cellssupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: M M U N O H I S T O C H E M I C a L F I N D I N G S C H Y M A S Epositive Mast Cellsmentioning

confidence: 99%

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Possible effect of thymoquinone on mast cell number and chymase, IL-4, IFN-γ expression in rat spleen

Ertuğrul¹,

Tütüncü²,

Ozdemir³

et al. 2021

Medycyna Weterynaryjna

Self Cite

View full text Add to dashboard Cite

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The role of resveratrol on mast cell and chymase and tryptase expression in blunt-chest-trauma-induced acute lung injury in rats

Cited by 1 publication

References 0 publications

Possible effect of thymoquinone on mast cell number and chymase, IL-4, IFN-γ expression in rat spleen

Possible effect of thymoquinone on mast cell number and chymase, IL-4, IFN-γ expression in rat spleen

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