The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review

Buglio, Daiene Santos; Marton, Ledyane Taynara; Laurindo, Lucas Fornari; Guiguer, Élen Landgraf; Araújo, Adriano Cressoni; Buchaim, Rogério Leone; Goulart, Ricardo de Álvares; Rubira, Cláudio José; Barbalho, Sandra Maria

doi:10.1089/jmf.2021.0084

Cited by 34 publications

(31 citation statements)

References 73 publications

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“…Also, in vitro assessment of S.uberis‐infected EpH4‐Ev cells showed that RSV induced‐P62 stimulation activated Nrf2 antioxidative signaling pathway. Due to its anti‐oxidative properties, it may be useful in the prevention and control of S.uberis ‐induced mastitis in cows (Buglio et al, 2022; Hao, Xing, & Gu, 2021; Meng et al, 2020).…”

Section: Effect On Oxidative Stressmentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', resveratrol hinders destructive effects of inflammatory causes and reactive oxygen radicals in several tissues. The nuclear erythroid 2‐related factor 2 is a factor related to transcription with anti‐inflammatory, antioxidant possessions which is complicated by enzyme biotransformation and biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the character of resveratrol against oxidative stress and regulation of inflammation via Nrf2 signaling pathway.

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Section: Effect On Oxidative Stressmentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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“…In fact, deacetylated PGC-1α can instill transcriptional repression of β-secretase, which in turn can reduce Aβ production levels and senile plaque accumulation (Xu et al, 2018). These results are corroborated by a systematic review where it has been shown the protective role of resveratrol in AD patients (Buglio et al, 2022). Recently, the analyses of PD animal and cellular models, showed that SIRT1 overexpression was able to suppress α-SYN aggregates formation, through the activation of the molecular chaperones, driven by Heat Shock Factor 1 (HSF1) deacetylation (Donmez et al, 2012).…”

Section: Sirt Proteins In Neurogenesis and Cns Aging-related Diseasesmentioning

confidence: 63%

Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogramming

Mormone

Iorio²,

Abate

et al. 2023

Front. Neurosci.

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Since the discovery of Neural Stem Cells (NSCs) there are still mechanism to be clarified, such as the role of mitochondrial metabolism in the regulation of endogenous adult neurogenesis and its implication in neurodegeneration. Although stem cells require glycolysis to maintain their stemness, they can perform oxidative phosphorylation and it is becoming more and more evident that mitochondria are central players, not only for ATP production but also for neuronal differentiation’s steps regulation, through their ability to handle cellular redox state, intracellular signaling, epigenetic state of the cell, as well as the gut microbiota-brain axis, upon dietary influences. In this scenario, the 8-oxoguanine DNA glycosylase (OGG1) repair system would link mitochondrial DNA integrity to the modulation of neural differentiation. On the other side, there is an increasing interest in NSCs generation, from induced pluripotent stem cells, as a clinical model for neurodegenerative diseases (NDs), although this methodology still presents several drawbacks, mainly related to the reprogramming process. Indeed, high levels of reactive oxygen species (ROS), associated with telomere shortening, genomic instability, and defective mitochondrial dynamics, lead to pluripotency limitation and reprogramming efficiency’s reduction. Moreover, while a physiological or moderate ROS increase serves as a signaling mechanism, to activate differentiation and suppress self-renewal, excessive oxidative stress is a common feature of NDs and aging. This ROS-dependent regulatory effect might be modulated by newly identified ROS suppressors, including the NAD+-dependent deacetylase enzymes family called Sirtuins (SIRTs). Recently, the importance of subcellular localization of NAD synthesis has been coupled to different roles for NAD in chromatin stability, DNA repair, circadian rhythms, and longevity. SIRTs have been described as involved in the control of both telomere’s chromatin state and expression of nuclear gene involved in the regulation of mitochondrial gene expression, as well as in several NDs and aging. SIRTs are ubiquitously expressed in the mammalian brain, where they play important roles. In this review we summarize the current knowledge on how SIRTs-dependent modulation of mitochondrial metabolism could impact on neurogenesis and neurodegeneration, focusing mainly on ROS function and their role in SIRTs-mediated cell reprogramming and telomere protection.

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“…RES can activate the human silent information regulator 2/SIRT‐1 and inhibit the nuclear factor‐κB, 5‐lipoxygenase and cyclooxygenase‐2 (COX‐2) to reduce the proinflammation pathways. It is also associated with increased levels of interleukin (IL)‐10, interferon‐γ and IL‐17 are also decreased 20 . Long‐term administration of RES tends to get a better curative effect and prevent dementia, whether for AD transgenic (3xTg‐AD) mice or non‐transgenic (No‐Tg) mice.…”

Section: Res and Alzheimer's Diseasementioning

confidence: 99%

“…It is also associated with increased levels of interleukin (IL)-10, interferonγ and IL-17 are also decreased. 20 Long-term administration of RES tends to get a better curative effect and prevent dementia, whether for AD transgenic (3xTg-AD) mice or non-transgenic (No-Tg) mice. Mice were fed with a diet supplemented with 100 mg/kg of RES from 2 months of age during the 10 months.…”

Section: Re S and Al Zheimer ' S D Is E A S Ementioning

confidence: 99%

Does resveratrol improve cognition in humans? A scientometric study to an in‐depth review

Song

Fan

2023

CNS Neurosci Ther

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Aim In order to understand the different processes and mechanisms of cognitive function and resveratrol (RES) as an active participant in pathophysiological events that affect cognitive function. Methods First, the Web of Science (core collection) was selected as the data source. To ensure the comprehensiveness and accuracy of the search data, the index was selected as “SCI‐EXPANDED”, and the search formula was TS = resveratrol AND TS = (“cognitive” OR “memory” OR “cognition” OR “mood”). Next, details of authors, keywords, journals, countries, institutions, references, and more were analyzed by CiteSpace and VOSviewer software. Finally, we explored the mechanism by which RES could improve cognitive impairment, that involves healthy young adults, healthy elderly, post‐menopausal women, and diseases involving Alzheimer's disease (AD), diabetes‐related cognitive impairment, mental illness, post‐stroke cognitive impairment, and neonatal hypoxic–ischemic injury. Results 287 valid papers were obtained. The scientometric results demonstrated 287 papers used in this study came from 1601 authors from 443 organizations in 38 countries, published in 169 journals, and cited 13,680 literatures from 2431 journals. Depression, AD, cerebral ischemia, diabetic cognitive impairment, and cognitive function in the elderly are all keywords of the co‐occurrence network. Conclusion This study supports the hypothesis that chronic RES intake may positively affect brain function. But it has become challenging to determine the optimal dose, time and duration of RES and improve the bioavailability of RES, which many researchers need to overcome.

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The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review

Cited by 34 publications

References 73 publications

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogramming

Does resveratrol improve cognition in humans? A scientometric study to an in‐depth review

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