“…Olitsky and Schlesinger (139) also stressed the factor of edema when they observed that hypertonic salt solution injected into the base of the tail of albino mice 31 to 24 hours before the cutaneous injection of herpes virus, increased infection both on the basis of success with one hundred fold greater dilution of the virus and also shortening of the incubation period by one-third. Mixtures of hypertonic solution plus virus, injection of the hypertonic solution after the virus, and application of virus after the edema had subsided showed no enhancing effect.…”