Effects of stress upon acquired immunity to the dwarf tapeworm, Hymenolepis nana

Weinmann, C. J.; Rothman, Alvin H.

doi:10.1016/0014-4894(67)90068-9

Cited by 23 publications

(3 citation statements)

References 25 publications

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“…Two studies of murine gastrointestinal infection due to the dwarf tapeworm Hymenolepsis nana have been reported, both of which used more naturally occurring stressors. Social stress (association with strange mice and severe fighting) of animals with acquired immunity to this parasite resulted in reinfection [126]. This effect was limited to mice with a low social status and was not observed in dominant males.…”

Section: Parasitic Infections Animal Studiesmentioning

confidence: 99%

Stress and Pathogenesis of Infectious Disease

Peterson

Chao

Molitor

et al. 1991

Clinical Infectious Diseases

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Despite inherent difficulties in defining and measuring stress, a scientific framework has been provided in recent years for understanding how disruptive life experiences might be translated into altered susceptibility to infectious diseases. Studies of the effects of stress on pathogenesis of infectious disease are highly relevant to assessment of the biological importance of the immune impairments that have been associated with stress. With a few notable exceptions, investigations of viral infections in humans and in animal models support the hypothesis that stress promotes the pathogenesis of such infections. Similar conclusions can be drawn from studies of bacterial infections in humans and animals and from a small number of studies of parasitic infections in rodent models. While many of these studies have substantial limitations, the data nonetheless suggest that stress is a potential cofactor in the pathogenesis of infectious disease. Given recent unprecedented advances in the neurosciences, in immunology, and in the field of microbial pathogenesis, the relationship between stress and infection should be a fruitful topic for interdisciplinary research."Thetoxin offatigue has been demonstrated; but the poisons generated by evil temper and emotional excess over non-essentials have not yet been determined, although without a doubt they exist."Elie Metchnikoff (1845Metchnikoff ( -1916

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Section: Parasitic Infections Animal Studiesmentioning

confidence: 99%

Stress and Pathogenesis of Infectious Disease

Peterson

Chao

Molitor

et al. 1991

Clinical Infectious Diseases

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“…Stress has been documented in animals undergoing reintroductions or translocations (Dickens et al 2010, Parker et al 2012. When the production of glucocorticoids due to chronic stress leads to immune system suppression (Dhabhar andMcEwen 1997, Godbout 2006), it could be possible for Hymenolepis cestodes to cause health problems (Weinmann and Rothman 1967). However, for all three parasites discussed above (the unknown Rodentolepis sp.…”

Section: Discussionmentioning

confidence: 99%

Protecting Free-Living Dormice: Molecular Identification of Cestode Parasites in Captive Dormice (Muscardinus avellanarius) Destined for Reintroduction

et al. 2016

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The success of any population translocation programme relies heavily on the measures implemented to control and monitor the spread of disease. Without these measures, programmes run the risk of releasing immunologically naïve species or, more dangerously, introducing novel infectious agents to native populations. As a precaution, a reintroduction programme for the common or hazel dormouse, Muscardinus avellanarius, in England screens dormice before release following captive breeding. Using PCR sequencing of a range of genes, we tested whether the same species of tapeworm(s) were present in captive and free-living dormice. Whilst only Rodentolepis straminea were identified in free-living dormice, cestode ova found in a captive individual produced a molecular match closely related to Hymenolepis microstoma and a previously unrecorded Rodentolepis species. To prevent putting at risk the free-living population, we recommended the continued treatment of dormice showing tapeworm infection before release. Our work demonstrates how molecular techniques can be used to inform reintroduction programmes, reduce risk from disease and increase chances of reintroduction success.

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“…Yet, as Pierce (1959) pointed out, little direct attention has been paid to this aspect of immunity to helminths. Since this time specific immunological activity against helminths in the gut has been demon-to 450 2-9 ±0-8 0-3 ±0-03 0-6 +0-1 32-1 ±1-7 3-6 ±0-5 0-1 ±0-001 8-3 450 21-4 +3-3 4-7 +1-0 2-2 ±0-3 45-6 ±2-6 10-4 +0-1 0-1 ±0-0007 10-5 (Douvres, 1962;Weinmann, 1963). However, there is much earlier work which shows the antiparasitic effects of mucus.…”

Section: Discussionmentioning

confidence: 99%

Changes in the protein content of the serum and intestinal mucus of sheep with reference to the histology of the gut and immunological response to Oesophagostomum columbianum infections

Dobson

1967

Parasitology

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Sheep infected with Oesophagostomum columbianum showed anorexia, loss of weight, diarrhoea and macroscopically obvious oedema and inflammation of the alimentary tract. Arthus-like lesions caused by the larvae developed particularly in the large intestine.The gross immunological responses of the sheep were associated with antibodies in greater titre within the mucus of the gut than in the serum. Acquired immunity was manifest through an antibody-antigen reaction which was localized mostly in the large intestine and which involved proliferation of the lymphoid tissue of the gut and an increased synthesis of protein. Lower titres of antibody in serum than in mucus may indicate leakage of antibody away from the gut. The direct effects of antibody were established by the respiratory inhibition of the 3rd-stage larvae. The presence of antibody was associated with particularly high concentrations of β globulin after first and β and γ globulins after second infection. Specific antibody was demonstrated in these protein fractions by blockage of electrophoretic movement by larval antigen in the buffer.The antibody-antigen reaction may act as a trigger which releases the nonspecific effects of excess mucus production and oedema which causes mechanical dislodgement of the infection. The natural and specific respiratory inhibitory effects of mucus on the worm would facilitate this dislodgement process.The greatest cellular reactions occurred where there was an active infection. Usually these reactions were associated with oedema, hyperaemia and an increase in the size of the mesenteric lymph nodes.

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Effects of stress upon acquired immunity to the dwarf tapeworm, Hymenolepis nana

Cited by 23 publications

References 25 publications

Stress and Pathogenesis of Infectious Disease

Stress and Pathogenesis of Infectious Disease

Protecting Free-Living Dormice: Molecular Identification of Cestode Parasites in Captive Dormice (Muscardinus avellanarius) Destined for Reintroduction

Changes in the protein content of the serum and intestinal mucus of sheep with reference to the histology of the gut and immunological response to Oesophagostomum columbianum infections

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