The Role of Reactive Oxygen Species in  Microvascular Remodeling

Staiculescu, Marius C.; Foote, Christopher; Meininger, Gerald A.; Martinez‐Lemus, Luis A.

doi:10.3390/ijms151223792

Cited by 54 publications

(43 citation statements)

References 302 publications

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“…Regulation of arteriolar diameter and blood flow in the microcirculation is a dynamic and well-controlled process that integrates signals from mechanical, chemical, hormonal and neuronal stimuli. This is also achieved by an ensemble of responses elicited by endothelial cells and smooth muscle cells [1,2]. Impaired arteriolar function, as observed in various cardiovascular pathologies such as hypertension, diabetes, stroke and aging, leads to vascular remodeling, tissue ischemia and organ damage [3,5–8].…”

Section: Introductionmentioning

confidence: 99%

Microvascular NADPH oxidase in health and disease

Pagano

2017

Free Radical Biology and Medicine

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The systemic and cerebral microcirculation contribute critically to regulation of local and global blood flow and perfusion pressure. Microvascular dysfunction, commonly seen in numerous cardiovascular pathologies, is associated with alterations in the oxidative environment including potentiated production of reactive oxygen species (ROS) and subsequent activation of redox signaling pathways. NADPH oxidases (Noxs) are a primary source of ROS in the vascular system and play a central role in cardiovascular health and disease. In this review, we focus on the roles of Noxs in ROS generation in resistance arterioles and capillaries, and summarize their contributions to microvascular physiology and pathophysiology in both systemic and cerebral microcirculation. In light of the accumulating evidence that Noxs are pivotal players in vascular dysfunction of resistance arterioles, selectively targeting Nox isozymes could emerge as a novel and effective therapeutic strategy for preventing and treating microvascular diseases.

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Section: Introductionmentioning

confidence: 99%

Microvascular NADPH oxidase in health and disease

Pagano

2017

Free Radical Biology and Medicine

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“…Then, blood flows from the capillaries into very small veins called venules, then through veins back to the heart. Thus, the primary function of supplying nutrient and oxygen to tissue occurs at the interface of the microvasculature, which is the network of small blood vessels that include arterioles, capillaries and venules [7]. Vessels are lined by endothelial cells (ECs) which are surrounded by perivascular cells (PVCs) such as smooth muscle cells or pericytes [8].…”

Section: Introductionmentioning

confidence: 99%

Vascularization strategies of engineered tissues and their application in cardiac regeneration

Sun

Altalhi

Nunes

2016

Advanced Drug Delivery Reviews

118

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“…ROS effects on apoptosis and vascular smooth muscle cells vary depending on the type and concentration of ROS and the amount of time the cell is exposed to the oxidant. 10 We believe that corneal vascularisation regressed in our case due to the direct toxic effect of ultraviolet light on the vessels and indirectly by ROS. However, UVA may have exerted some antiangiogenic effect on the corneal blood vessels as in the case of psoriatic skin.…”

Section: Discussionmentioning

confidence: 54%

Extensive Corneal Neovascularisation Treatment by Ultraviolet Corneal Collagen Crosslinking

Shehadeh¹,

Akkawi²,

Diakonis³

et al. 2017

European Ophthalmic Review

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T he purpose of this article is to report a case of extensive corneal neovascularisation that was treated by ultraviolet corneal collagen crosslinking (CXL). The case report is about a 24-year-old man who was referred to the cornea clinic with a case of keratitis. He was treated with topical antibiotics. After full resolution of keratitis, his condition was complicated by extensive corneal neovascularisation. A trial of photochemical corneal collagen CXL with riboflavin/ultraviolet A resulted in a dramatic improvement and resolution of the corneal neovascularisation. Thus, we can conclude that corneal collagen CXL could be a promising procedure to treat certain cases of extensive corneal neovascularisation. KeywordsCorneal neovascularisation, collagen crosslinking, keratitis, riboflavin Compliance with Ethics: All procedures were followed in accordance with the responsible committee on human experimentation and with the Helsinki Declaration of 1975 and subsequent revisions, and informed consent was received from the patient involved in this case study.Authorship: All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval to the version to be published.Open Access: This article is published under the Creative Commons Attribution Noncommercial License, which permits any non-commercial use, distribution, adaptation and reproduction provided the original author(s) and source are given appropriate credit. Riboflavin/ultraviolet A (UVA) crosslinking (CXL) is a technique that was introduced several years ago for the treatment of keratectasia, keratoconus and infectious keratitis.2 Herein, we report a case of extensive corneal neovascularisation which was treated by ultraviolet corneal collagen CXL.Corneal collagen CXL could be an enormous hope in the treatment of corneal neovascularisation mentioning the limitations and undesirable side effects of the current treatment options for it. To our knowledge, this is the first report of using CXL to treat corneal neovascularisation. Case ReportA 24-year-old man without known previous medical illnesses; his past ocular history included left eye penetrating corneal trauma, treated with a rotational flap 7 years prior to presentation. The patient was treated for 2 weeks as a case of herpetic keratitis in a private clinic with oral acyclovir 800 mg five times daily, gatifloxacin 0.3% eye drops (E/D) every 2 hours (q2h) and atropine E/D q12h. There was no response to treatment and so was referred to our cornea clinic for further management.On examination, the patient visual acuity (VA) was 1.0 OD, hand motion OS. Slit lamp examination revealed normal right eye, while a left eye examination showed purulent discharge, severely injected conjunctiva, central corneal abscess, corneal neovascularisation and 1 mm hypopyon.Lens and posterior segment were invisible, so B-scan ultrasonography was performed and revealed a clear vi...

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The Role of Reactive Oxygen Species in Microvascular Remodeling

Cited by 54 publications

References 302 publications

Microvascular NADPH oxidase in health and disease

Microvascular NADPH oxidase in health and disease

Vascularization strategies of engineered tissues and their application in cardiac regeneration

Extensive Corneal Neovascularisation Treatment by Ultraviolet Corneal Collagen Crosslinking

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