The Role of Processing Speed in Post-Stroke Cognitive Dysfunction

Abstract

The association between speed of information processing and cognition has been extensively validated in normal aging and other neurocognitive disorders. Our aim was to determine whether such a relationship exists in stroke. Thirty patients and 30 age- and education-matched healthy individuals were administered a comprehensive battery of neuropsychological tests divided into the following six cognitive domains: processing speed (PS), verbal memory, visual memory, visuoperceptual function, language, and cognitive flexibility. The results demonstrate that stroke patients were characterized by cognitive deficits in almost all of these domains, but have the most pronounced deficits in PS. After adjusting for symbol digit modalities test score, all significant group differences in cognitive functioning disappeared. However, group differences remained significant after controlling for the influence of other cognitive factors. These findings suggest that decreased PS appears to underlie post-stroke cognitive dysfunction and may serve as a potential target for intervention.

Cerebellar Fastigial Nucleus Electrical Stimulation Alleviates Depressive-Like Behaviors in Post-Stroke Depression Rat Model and Potential Mechanisms

“…Sui et al discovered that emotion disorders in post-stroke patient can be improved by fastigial nucleus electrical stimulations [12]. Likely, Su et al reported that electrical stimulation cerebellar fastigial nucleus showed substantially alleviated symptom of patients who had PSD, in comparison to healthy controls [13]. Electrical stimulation excites fibers passing through the fastigial nucleus, leading to increased blood pressure, reflexive vascular expansion, and increased rCBF [14].…”

Computerized Cognitive Rehabilitation of Attention and Executive Function in Acquired Brain Injury: A Systematic Review

“…1 Persistent cognitive deficits are common following ABI, particularly in executive functioning, attention, and learning. 2–4 These multiple cognitive deficits, coupled with other frequently associated neuropsychiatric or motor symptoms, have a detrimental effect on functional status and may lead to disability. 5–7 Improvement of executive abilities and attentional capacity also contributes to recovery in other functional domains 8,9 and may significantly reduce disability and improve quality of life in individuals with ABI.…”

Fastigial nucleus stimulation ameliorates cognitive impairment via modulating autophagy and inflammasomes activation in a rat model of vascular dementia

“…17 Similarly, Su et al 18 showed that electrical FNS could significantly alleviate the symptoms of PSD patients. 17 Similarly, Su et al 18 showed that electrical FNS could significantly alleviate the symptoms of PSD patients.…”