The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation

Stanciu, Adina Elena; Vătăşescu, Radu; Stanciu, Mihai; Serdarevic, Nafija; Dorobanțu, Maria

doi:10.1016/j.cyto.2017.12.026

Cited by 43 publications

(35 citation statements)

References 23 publications

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“…OSCC is more common among males than females, with a ratio ranging from 2:1 to 4:1 (22). Thus, only male subjects were included in this study (patients and control groups) to avoid inter sex-related variations (25,26).…”

Section: Patientsmentioning

confidence: 99%

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

et al. 2019

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Melatonin, the primary hormone produced by the pineal gland, is intensely assessed for its anticancer properties. This study aimed to reveal the clinical significance of serum melatonin levels in predicting the severity of oral squamous cell carcinoma (OSCC). For this purpose, 40 male patients with OSCC and 30 healthy subjects were enrolled in this study. The serum levels of melatonin were determined by ELISA. The results revealed that the melatonin concentrations were significantly lower in the patients with OSCC compared with the controls (18.2 vs. 47.6 pg/ml, P<0.001). In addition, the serum melatonin levels had a high predictive accuracy for discriminating patients with OSCC with T-depth of invasion (DOI) II from the healthy controls (89.1%), as well as in discriminating patients with OSCC with nodal metastasis from those without nodal metastasis (83.8%). On the whole, the findings of this study suggest that the serum melatonin concentrations are closely related to the severity of OSCC and may thus be used to assess the different stages of oral cancer objectively and accurately. The present study also supports the conclusion that melatonin may be a potential therapeutic agent for use in the treatment of patients with OSCC.

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Section: Patientsmentioning

confidence: 99%

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

et al. 2019

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“…At present, there are no recommendations on the use of AF-specific biomarkers in the most recent guidelines [ 3 , 6 ], despite the fact that several blood-based biomarkers related to AF pathology have been identified. These biomarkers include brain natriuretic peptides, cancer-antigen-125, fibroblast growth factor-23 [ 7 , 8 ] and -21 [ 9 ], highly sensitive cardiac troponin I [ 10 ], homocysteine [ 11 ], (a)symmetric dimetylarginine [ 12 ], interleukine-6 and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio [ 13 ]. Although potential AF-related biomarkers are available, the role of these biomarkers in staging of AF (paroxysmal or (longstanding) persistent AF) or predicting AF recurrence after AF therapy has only be moderately studied.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation

Marion

Lanters

Ramos

et al. 2020

Cells

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Background: Staging of atrial fibrillation (AF) is essential to understanding disease progression and the accompanied increase in therapy failure. Blood-based heat shock protein (HSP) levels may enable staging of AF and the identification of patients with higher risk for AF recurrence after treatment. Objective: This study evaluates the relationship between serum HSP levels, presence of AF, AF stage and AF recurrence following electrocardioversion (ECV) or pulmonary vein isolation (PVI). Methods: To determine HSP27, HSP70, cardiovascular (cv)HSP and HSP60 levels, serum samples were collected from control patients without AF and patients with paroxysmal atrial fibrillation (PAF), persistent (PeAF) and longstanding persistent (LSPeAF) AF, presenting for ECV or PVI, prior to intervention and at 3-, 6- and 12-months post-PVI. Results: The study population (n = 297) consisted of 98 control and 199 AF patients admitted for ECV (n = 98) or PVI (n = 101). HSP27, HSP70, cvHSP and HSP60 serum levels did not differ between patients without or with PAF, PeAF or LSPeAF. Additionally, baseline HSP levels did not correlate with AF recurrence after ECV or PVI. However, in AF patients with AF recurrence, HSP27 levels were significantly elevated post-PVI relative to baseline, compared to patients without recurrence. Conclusions: No association was observed between baseline HSP levels and the presence of AF, AF stage or AF recurrence. However, HSP27 levels were increased in serum samples of patients with AF recurrence within one year after PVI, suggesting that HSP27 levels may predict recurrence of AF after ablative therapy.

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“…Studies from the past 40 years have reported that matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, and the tissue inhibitor of metalloproteinases (TIMPs), are the principal mediators of the alterations observed in the tumor microenvironment during cancer progression, indicating that they are directly involved in the majority of biological processes leading to metastasis (4). MMP expression is controlled by various hormones (estrogen and progesterone), cytokines (interleukins and interferons) and growth factors (epidermal growth factor, fibroblast growth factor, vascular endothelial growth factor and tumor growth factors) (4,5). Loco-regional metastases are hallmarks of OSCC.…”

Section: Introductionmentioning

confidence: 99%

Serum melatonin is inversely associated with matrix metalloproteinase‑9 in oral squamous cell carcinoma

et al. 2020

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Matrix-metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) expression levels have been demonstrated to have prognostic value in oral squamous cell carcinoma (OSCC). The present study hypothesized that melatonin, a small lipophilic molecule primarily secreted by the pineal gland, may be able to regulate MMP activity in OSCC progression. This study aimed to investigate the associations between melatonin, MMPs, TIMPs and the histopathological characteristics of patients with OSCC. A total of 40 men with OSCC (mean age, 57±7 years) and 30 healthy men (mean age, 56±5 years) were enrolled in the present study. Enzyme immunoassays were used to measure the serum levels of melatonin, MMP-9, MMP-2, TIMP-1 and TIMP-2 before and after transoral surgery for OSCC. Serum melatonin level was significantly lower in patients with OSCC compared with controls, both pre-surgery and 2 days after surgery (P<0.001). In addition, melatonin level was negatively correlated with MMP-9 (r=-0.6371) and the MMP-9/TIMP-1 ratio (r=-0.4700), but not with the MMP-2 or MMP-2/TIMP-2 ratio, in patients with OSCC. These results demonstrated that low levels of melatonin and high levels of MMP-9 correlated with large tumors with invasive depth (r=-0.35 and r=0.33) and lymph node metastasis (r=-0.56 and r=0.34). The results of this retrospective clinical study suggested that melatonin may be considered as a predictive biomarker of tumor growth and metastasis and a potential therapeutic agent for patients with OSCC.

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The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation

Cited by 43 publications

References 23 publications

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation

Serum melatonin is inversely associated with matrix metalloproteinase‑9 in oral squamous cell carcinoma

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