The role of pretreatment serum albumin to predict pathological stage and recurrence among radical prostatectomy cases

Richter, E; Connelly, RR; Jw, Mason

doi:10.1038/sj.pcan.4500418

Cited by 13 publications

(13 citation statements)

References 22 publications

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“…Many other studies such as Strasak et al 8 in Austria, Levine et al 4 in USA, Bengston et al 5 and Petterson el 10 all found that high serum uric acid was associated with higher risk of cancer mortality, although, they did not observe serum uric acid association with cancer incidence and other factors. However, Hiatt and Fireman 2 in prospective cohort study, found no association between serum uric acid with cancer incidence after adjusting for age, race, education, tobacco, alcohol intake, and body mass index.…”

Section: Discussionmentioning

confidence: 89%

“…These hormones are associated with increased muscle mass and increased muscle mass may lead to greater tissue turnover and DNA catabolism and thus high serum uric acid levels. 10 These possibilities may be in part, responsible for the inconsistent results gotten from studies in the relationship between serum uric acid and cancer incidence and mortality.…”

Section: Discussionmentioning

confidence: 99%

“…10 Serum uric acid level is determined by both endogenous production and exogenously by ingestion from dietary sources. It is believed that up to 50% of serum uric acid is from dietary sources including liver, mussels, sardines and sausages.…”

Section: Discussionmentioning

confidence: 99%

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Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria

et al. 2012

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria

et al. 2012

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“…Albumin levels are known to decrease as part of a systemic inflammatory response in cancer (27). Moreover, low albumin levels within the normal range have been reported to be significantly associated with an increased risk of local metastatic disease (28) and with death from prostate cancer (29).…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study of Total and Ionized Serum Calcium and Time to Fatal Prostate Cancer

Schwartz

Skinner

2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Higher levels of total and ionized serum calcium have been shown to predict fatal prostate cancer in prospective studies. Because the follow-up time in these studies was relatively short, these associations could reflect the effect of clinically significant but occult prostate tumors on serum calcium levels. If this were true, prostate cancer mortality rates among men with higher levels of serum calcium should be higher during the early follow-up period and should decline thereafter.Methods: We tested this hypothesis by estimating the relative risk of death from prostate cancer in the National Health and Nutrition Examination Survey III for incremental increases in total and ionized serum calcium using Cox proportional hazards regression with time-dependent effects.Results: Forty-nine (49) fatal prostate cancers occurred over 204 months of follow-up and 1,069,327 person-months of observation. Men with higher total serum calcium and higher serum ionized calcium had increased risks of fatal prostate cancer during the first 96 months of follow-up [Relative Hazard (RH) ¼ 1.50 per 0.1 mmol/L total serum calcium, 95% confidence interval (CI) ¼ 1.04-2.17; RH ¼ 1.72 per 0.05 mmol/L ionized calcium, 95% CI ¼ 1.11-2.66]. Evidence of an association between total and ionized serum calcium and prostate cancer deaths was not significant after 96 months.Conclusions: Our analyses support the hypothesis that the elevated risk for fatal prostate cancer observed in men with high serum calcium is because of the presence of extant, but occult prostate cancer.Impact: These findings have implications for the potential use of serum calcium in the detection of clinically significant prostate cancer. Cancer Epidemiol Biomarkers Prev; 21(10); 1768-73. Ó2012 AACR.

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“…Albumin is proposed to have antioxidant potential. This may be related to the abundance of sulfhydryl (-SH) groups on the Albumin molecule along with free Thiol groups [30,31]. Owing to this it can provide ten times more antioxidant protection as compared to other plasma protein against various Reactive Oxygen Species.…”

Section: Discussionmentioning

confidence: 99%

Implication of Serum and Salivary Levels of Albumin as a Diagnostic Tool in Oral Premalignancy and Malignancy

Sinha

2020

APALM

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Background: Reactive oxygen and nitrogen species are involved in the initiation and promotion of the multistep carcinogenesis. In neoplastic conditions many biochemical substances many biochemical substances including albumin show altered values .The aim of the present study was to investigate whether serum and salivary albumin levels can be used as diagnostic tools in oral premalignant and malignant leisons. Methods:The study includes a total of 45 subjects with 15 each of normal healthy, pre-malignancy and malignancy. Fivemilliliter of venous blood was drawn and unstimulated saliva was collected in the early morning. Albumin levels were estimated by Bromocresol Green Method.Results: Serum albumin levels were found to decrease in pre-malignancy and malignancy as compared to healthy individuals. Salivary Albumin levels were increased in pre-malignancy and malignancy as compared to healthy individuals. Conclusion:Tobacco consumption is one of the most important risk factors for the development of oral cancer. Burst of reactive oxygen species which cause oxidative stress in tobacco users is prime form of damage brought to the genetic material leading to non-lethal mutations causing pre-malignancy and malignancy.Serum protein has long been implicated to have anti-oxidant properties due to rich concentration of free thiol group. Albumin is a potent extracellular anti oxidant defense and a reliable marker of oxidative stress in the body. It could be helpful in the early identification of various oral pre malignancy and malignant leisons.

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The role of pretreatment serum albumin to predict pathological stage and recurrence among radical prostatectomy cases

Cited by 13 publications

References 22 publications

Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria

Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria

A Prospective Study of Total and Ionized Serum Calcium and Time to Fatal Prostate Cancer

Implication of Serum and Salivary Levels of Albumin as a Diagnostic Tool in Oral Premalignancy and Malignancy

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