Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria

Lawal, A O; Kolude, Bamidele; Adeyemi, B F; Jo, Lawoyin; Akang, E. E. U.

doi:10.4103/1119-3077.94093

Cited by 31 publications

(37 citation statements)

References 10 publications

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“…Zheng et al (1993) also reported significant association between retinol and α-tocopherol with oral cancer risk. This finding is further corroborated by an earlier study where serum level of vitamin A (a group of organic compound including retinol) and E (a group of organic compound including tocopherol) was also found to be lower in cases as compared to controls where low serum level of these vitamins was associated with 10.9 times and 5.6 times increased risk for oral cancer (Lawal et al, 2012). Inverse association of retinol and α-tocopherol have also been reported in other cancers such as lung (Klarod et al, 2011), breast (Shim et al, 2012) and gastric cancer (Jenab et al, 2006).…”

Section: Discussionsupporting

confidence: 77%

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

Athirajan¹,

Razak²,

Thurairajah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: A comparative cross-sectional study involving oral cancer patients and healthy individuals was designed to investigate associations between retinol, α-tocopherol and β-carotene with the risk of oral cancer. Materials and Methods: This study included a total of 240 matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). Retinol, α-tocopherol and β-carotene levels and intake were examined by high-performance liquid chromatography (HPLC) and food frequency questionnaire (FFQ) respectively. Results: It was found that results from the two methods applied did not correlate, so that further analysis was done using the HPLC method utilising blood serum. Serum levels of retinol and α-tocopherol among cases (0.177±0.081, 1.649±1.670µg/ml) were significantly lower than in controls (0.264±0.137, 3.225±2.054µg/ml) (p<0.005). Although serum level of β-carotene among cases (0.106±0.159 µg/ml) were lower compared to controls (0.134±0.131µg/ml), statistical significance was not observed. Logistic regression analysis showed that high serum level of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and α-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer, whereas no relationship was observed between β-carotene and oral cancer risk. Conclusions: High serum levels of retinol and α-tocopherol confer protection against oral cancer risk.

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Section: Discussionsupporting

confidence: 77%

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

Athirajan¹,

Razak²,

Thurairajah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The synergism among vitamin E, ascorbate, and selenium inhibits DNA and RNA protein synthesis in the cells. 10 In the present study, mean serum vitamin E levels inpatients with oral potentially malignant disorders were significantly lower than that in controls, which is in agreement with a study by Gupta et al on oral submucous fibrosis. This could be attributed to the potent lipophilic action of vitamin E, which gets consumed in conditions of oxidative stress, thus lowering its levels.…”

Section: Discussionsupporting

confidence: 82%

Assessment of Serum and Salivary Vitamin E Levels in Oral Potentially Malignant Disorders and Oral Cancer

Bhat¹,

Babu²,

N³

et al. 2018

J Dent Indones

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An increase in lipid peroxidation and a decrease in antioxidant activity have been reported in patients with cancer in comparison with normal subjects. Objective: To estimate the status of serum and saliva by assessing the serum and salivary vitamin E levels in patients with oral potentially malignant disorders and oral cancer. Methods: A total of 90 participants were enrolled in this study. 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls). Serum and saliva samples were collected and vitamin E levels were assessed. The data were analyzed using ANOVA for between-group comparison. Post hoc Tukey analysis was used for comparing the two study groups with the control group. Pearson correlation coefficient was used to determine concordance between the groups. Results: Mean vitamin E levels in serum and saliva were significantly decreased in oral potentially malignant disorders and oral cancer compared with controls. Conclusion: As significant reduction in vitamin E levels was observed in saliva, it was evident that salivary vitamin E levels potentially be used as a reliable, non invasive biomarker for diagnosing and managing oral potentially malignant disorders and oral cancer.

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“…The discussion in these studies was based on the fact that the increase in the incidence and mortality rates of many cancer types might be due to the loss of protective feature of uric acid in case of low serum concentration levels [21]. Bozkir et al [22], in their study comparing healthy control subjects with lung cancer patients, found that serum uric acid levels of the lung cancer patients were significantly lower.…”

Section: Discussionmentioning

confidence: 98%

“…Some studies have emphasized low serum uric acid level's association with increased cancer prevalence and high mortality rate [21][22][23]. The discussion in these studies was based on the fact that the increase in the incidence and mortality rates of many cancer types might be due to the loss of protective feature of uric acid in case of low serum concentration levels [21].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of the baseline serum uric acid level in non-small cell lung cancer patients treated with first-line chemotherapy: a study of the Turkish Descriptive Oncological Researches Group

et al. 2014

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Non-small cell lung cancer (NSCLC) is one of the most common cancers. Most of the patients are inoperable at the time of diagnosis, and the prognosis is poor. Many prognostic factors have been identified in prior studies. However, it is not clear which factor is more useful. In this study, we investigated whether uric acid, the last breakdown product of purine metabolism in humans, has a prognostic significance in advanced NSCLC. A total of 384 NSCLC patients at stage IIIB/IV and who did not meet exclusion criteria were included in this retrospective cross-sectional study. The patients' serum uric acid levels before first-line chemotherapy and demographic (age, gender, smoking), clinical (performance status, weight loss, disease stage, first-line treatment regimen), laboratory (hemoglobin, lactate dehydrogenase), and histologic (histologic type, tumor grade) characteristics were recorded. First, a cut-off value was determined for serum uric acid level. Then, the patients were stratified into four groups (quartiles) based on their serum uric acid levels. Descriptive statistics, univariate and multivariate analyses, and survival analyses were used. Majority of the patients were males, smokers and metastatic at time of diagnosis and had history of weight loss and adenocarcinoma upon pathological examination. The serum uric acid levels of all patients were determined as 4.9±2.9 (range 1.9-11.3). The patients were stratified according to quartiles of serum uric acid concentration with cutoff values defined as <3.08 mg/dL (lowest quartile, Group 1), 3.09-5.91 mg/dL (Group 2), 5.92-7.48 mg/dL (Group 3), and >7.49 mg/dL (highest quartile, Group 4). Among the patients who had serum uric acid levels over 7.49, it was observed that those who also had squamous cell carcinoma had a greater rate of brain metastasis, a shorter time lapse until brain metastasis, and lower overall survival rate. It can be assumed that NSCLC patients who had histologically shown squamous cell carcinoma display brain metastasis and poor prognosis. It can be recommended to repeat this study with larger patient series including immunohistochemical, molecular, and wider laboratory investigations.

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Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria

Abstract: The lower serum vitamin A, C, and E levels in oral cancer patients could be either a cause or an effect of the oral cancer. Further studies using a larger sample size and cohort studies with long-term follow-up of subjects are desirable.

Cited by 31 publications

References 10 publications

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

Assessment of Serum and Salivary Vitamin E Levels in Oral Potentially Malignant Disorders and Oral Cancer

Prognostic significance of the baseline serum uric acid level in non-small cell lung cancer patients treated with first-line chemotherapy: a study of the Turkish Descriptive Oncological Researches Group

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