The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer

Demir, Fadime; Şimşek, Fikri Selçuk; Balcı, Tansel Ansal

doi:10.4274/mirt.galenos.2018.09825

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Demir et al. ( 52 ) used serum Tg and Tg/TSH values associated with DM and found that their areas under ROC were 0.990 and 0.991, respectively. Tg/TSH was therefore confirmed as an early biomarker for DM ( 53 ).…”

Section: The Role Of Tg In Postoperative Patients With Dtcmentioning

confidence: 99%

The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer

Ren

Gong

et al. 2022

Front. Endocrinol.

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Thyroglobulin (Tg) is secreted by thyroid follicular cells and stored in the thyroid follicular lumen as a component of thyroid hormone. It is known that both benign and well-differentiated malignant thyroid tissue can secrete Tg. In recent years, growing lines of evidence have shown that Tg plays an important role in the diagnosis and metastasis of preoperative differentiated thyroid carcinoma (DTC). The levels of Tg, whether in the serum or in a fine-needle aspiration washout fluid, are usually viewed as an excellent indicator in the monitoring of postoperative DTC, including the guidance and evaluation of radioactive iodine ablation. Nevertheless, some factors limit the application of Tg, such as the method used to measure Tg and the presence of Tg antibodies. This review aimed to summarize the role of Tg in the preoperative and postoperative evaluation of patients with DTC, and the factors influencing Tg. This review could provide a reference for a more accurate application of Tg in patients with DTC.

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Section: The Role Of Tg In Postoperative Patients With Dtcmentioning

confidence: 99%

The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer

Ren

Gong

et al. 2022

Front. Endocrinol.

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“…Fadime et al (26) showed that serum Tg can not only effectively diagnose thyroid cancer, but also predict lymph node metastasis. Rakib et al (27) showed that detection of TgAb level could differentiate benign and malignant thyroid nodules.…”

Section: Analysis Of the Value Of The Combined Detection Of Serum Tg ...mentioning

confidence: 99%

Diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma

Min

Xiaxing

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This study aimed to explore the value of combined detection of serum thyroglobulin (Tg), interferon - γ (IFN - γ) and thyroglobulin antibody (TgAb) in the diagnosis and prognosis of thyroid adenoma (TA). For this purpose, 100 patients with TA in our hospital from January 2017 to December 2020 were selected as the observation group, and they were divided into good prognosis group (83 cases) and poor prognosis group (17 cases) according to the surgical treatment; another 50 healthy people who received physical examination in our hospital. The levels of serum Tg, IFN - γ and TgAb in each group were detected and compared; the diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma were analyzed. Results showed that compared with the control group, the levels of Tg and TgAb in the observation group were significantly increased, and the levels of IFN - γ were significantly decreased (P < 0.05); compared with the poor prognosis group, the levels of Tg and TgAb in the good prognosis group were significantly decreased, and the levels of IFN - γ were significantly increased (P < 0.05); The area under curve (AUC) of the combined detection of serum Tg, IFN-γ and TgAb for TA diagnosis and prognosis assessment was significantly higher than the value detected by a single indicator. In general, the combined detection of serum Tg, IFN - γ and TgAb has high diagnostic and prognostic value for TA, and has high clinical reference value.

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A novel nomogram integrated with preablation stimulated thyroglobulin and thyroglobulin/thyroid-stimulating hormone ratio to predict the therapeutic response of intermediate‑ and high‑risk differentiated thyroid cancer patients: a bi-center retrospective study

Wen,

Zhao,

Chen

et al. 2023

Endocrine

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The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer

Cited by 4 publications

References 16 publications

The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer

The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer

Diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma

A novel nomogram integrated with preablation stimulated thyroglobulin and thyroglobulin/thyroid-stimulating hormone ratio to predict the therapeutic response of intermediate‑ and high‑risk differentiated thyroid cancer patients: a bi-center retrospective study

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