The Role of Postmastectomy Radiation Therapy After Neoadjuvant Chemotherapy in Clinical Stage II-III Breast Cancer Patients With pN0: A Multicenter, Retrospective Study (KROG 12-05)

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2016

“…A metaanalysis and further data from randomized con trolled trials have improved the evidence levels indicating postmastectomy irradiation (PMRT) [102][103][104][105]. PMRT is beneficial for all patients with 'highrisk' criteria in terms of both locoregional tumor control and overall survival.…”

Post-mastectomy radiotherapy after neodjuvant chemotherapy in breast cancer patients: A review

“…The main scientific sources assessing the exact place of post-NAC PMRT in breast cancer patients are of two orders: most reports are derived from retrospective studies on patients cohorts [1,12,13,[17][18][19][20][21][22][23][24][25][26][27][28] and only one analysis relates to data retrieved from two prospective trials (NSABP B18 and B27) [1]. There is so far no published result from large randomized trials comparing PMRT to no PMRT in patients treated with neo-adjuvant chemotherapy.…”

“…Table 1 lists the main variables identified in the literature on post-NAC PMRT [1][2][3][12][13][14][19][20][21][22][23][24][25][26][27][28]. There are a high number of host-, disease-and treatment-related parameters shown to reach statistically significant levels and, in terms of treatment outcome, their relevance quite markedly vary among the reports, even for those published in a recent past.…”

“…Classes and types of risk factors Buchholz [1,2] Huang [8,9] Garg [19,20] Truong [21,22] McGuire [14] Nagar [23] Mamounas [1] Fowble [24] Allis [25] Wright [26] Moo [27] Shim [28] Clinical In the combined analysis of these two NAC trials, patients who achieved a pCR continue to have significantly superior DFS and OS outcomes compared with patients who did not. In the 1071 patients treated by mastectomy, the 10-year cumulative incidence of LRR was 12.3% for mastectomy patients: 8.9% of them were local, 3.4% regional.…”

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2014

“…A meta-analysis and further data from randomized controlled trials have improved the evidence levels indicating postmastectomy irradiation (PMRT) [102,103,104,105]. PMRT is beneficial for all patients with ‘high-risk' criteria in terms of both locoregional tumor control and overall survival.…”