The role of positron emission tomography with¹⁸F-2-fluoro-2-deoxy-D-glucose in respiratory oncology

Abstract

The role of positron emission tomography with 18 F-¯uoro-2-deoxy-D-glucose in respiratory oncology.

Endobronchial ultrasound and positron emission tomography positive mediastinal lymph nodes

“…In order to further assess whether FDG-PET effectively contributes to the high diagnostic yield in the present study, a randomised study comparing TBNA combined with EBUS, with or without prior evaluation with FDG-PET, should be required. One problem with such a study, however, is related to the fact that a PET scan has also been shown to afford significant additional information in the search for metastasis of lung cancer, as well as being cost-effective [4,19].…”

“…FDG-PET has a sensitivity of 0.85, a specificity of 0.88, a positive predictive value of 0.78, and a negative predictive value of 0.93 [3]. It has then been suggested that a negative mediastinal FDG-PET result may obviate the need for invasive lymph node sampling [4], but a positive one needs to be confirmed [4,5]. In case of positive mediastinal FDG-PET results, further assessment using mediastinoscopy is still considered as the ''gold-standard'' [3].…”

“…Using this criterion, however, the sensitivity and specificity of CT are only 0.57 and 0.82, respectively [3]. Recently, the positron emission tomography with 18F-fluoro-2-deoxy-D-glucose (FDG-PET) has been shown to be more accurate than CT in the evaluation of mediastinal lymph node involvement [4]. It is now used in many countries, in addition to CT, to further improve the sensitivity and specificity rates of the noninvasive assessment of mediastinal lymph nodes.…”

The sensitivity of 18F-fluorodeoxyglucose positron emission tomography in the evaluation of metastatic pulmonary nodules☆

“…The detection of these photons by the PET camera generates the image. The concomitant detection of background gamma photons limits the spatial resolution of small nodules [12,13]. In vitro the minimal detection limit of FDG-PET is about 10 6 cells, which corresponds to a tumor diameter of 1 mm.…”

Angiosarcoma in the right atria demonstrated by fusion images of multislice computed tomography and positron emission tomography using F-18 Fluoro-Deoxyglucose

“…As a semiquantitive index of FDG uptake, SUV are widely used to differentiate malignant from benign lesions, e.g. in solitary pulmonary lesions, an SUV N2.5 is considered to be evidence of malignancy [8] with a high degrees of accuracy. In the case reported here, while 67 Ga and 99 mTc-scintigram revealed negative findings in the RA, FDG-PET revealed positive findings in the RA accurately, with a SUV 9.89N 2.5.…”