The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers

Ilchenko, S.I.; Фиалковская, А А; Kramarenko, N. N.; Макух, Г В

doi:10.26641/2307-0404.2017.2.109834

Cited by 3 publications

(2 citation statements)

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“…Therefore, an important internal risk factor for the development of CB is the genetic predisposition, with which the features of immunological reactivity, growth and development of the lungs are closely linked [8]. Today, the genetic mechanisms of the formation of COPD in adults have become the object of largescale research around the world [9,10,11]. But in childhood, the genetic risk factors for chronic respiratory diseases, except for bronchial asthma and cystic fibrosis, have practically not been studied.…”

Section: Introductionmentioning

confidence: 99%

Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers

et al. 2020

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The aim is to study the clinical features of the course of CB in adolescent smokers and to study the genetic risk factors for the development of COPD. Materials and methods: There were examined 40 adolescent smokers with CB, 30 never-smokers adolescents with CB and 37 healthy adolescents smokers (control group). The study included the collection of anamnesis, objective examination. calculation of the smoking index and the «pack/year», molecular genetic investigations. Results: It was proved that smoking leads to the development of chronic bronchitis as early as adolescence and affects its course, increasing the frequency and duration of exacerbations. We identified an association of the 2G/2G genotype of MMP1 gene with the development of chronic bronchitis in adolescent smokers. The TT genotype of CYP1A1 gene may be considered as a possible sustainability factor for the development of chronic bronchitis in adolescent smokers. Conclusions: The study of candidate genes for COPD in childhood and adolescence will facilitate the early detection of high-risk groups in the formation of this pathology, which will allow doctors to take the necessary preventive measures.

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Section: Introductionmentioning

confidence: 99%

Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers

et al. 2020

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“…Therefore, genetic predisposition with regard to immunological reactivity and growth and development of the lungs are closely linked [8]. Today, the genetic mechanisms responsible for the formation of COPD in adults have become the object of large-scale research around the world [9][10][11], but in childhood, the genetic risk factors for chronic respiratory diseases, except for bronchial asthma and cystic fibrosis, have been largely ignored. Thus, the study of the role of tobacco smoking in the development of CB in children and adolescents with analysis of molecular genetic factors can provide additional information on the mechanisms of disease formation and will allow us to predict these conditions and develop methods for disease prevention.…”

Section: Introduction Chronic Bronchitis (сB) In Childrenmentioning

confidence: 99%

Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers

Ilchenko

Fialkovska

2019

IJIPEM

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Clinical features and molecular genetic risk factors for the development of chronic bronchitis in adolescent smokers.

Ilchenko¹,

Fialkovska²

2019

Medicni Perspektivi (Medical Perspectives)

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The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers

Cited by 3 publications

References 4 publications

Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers

Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers

Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers

Clinical features and molecular genetic risk factors for the development of chronic bronchitis in adolescent smokers.

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