Abstract:Med15 is a general transcriptional regulator and member of the tail module of the RNA Pol II Mediator complex. The S. cerevisiae Med15 protein has a well-structured N-terminal KIX domain, three Activator Binding Domains (ABDs) and several naturally variable polyglutamine(poly-Q) tracts (Q1, Q2, Q3) embedded in an intrinsically disordered central region, and a C-terminal Mediator Association Domain (MAD). We investigated how the presence of ABDs and changes in length and composition of poly-Q tracts influences … Show more
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