The role of platelets in inflammation and immunity

Цель исследования-изучить ассоциации между маркерами эндотелиальной дисфункции, системного воспаления и агрегационными свойствами тромбоцитов у пациентов со стабильной стенокардией напряжения (ССН). Материалы и методы. Обследованы 100 пациентов со ССН, средний возраст-59,2±6,9 лет, получавших двойную антитромбоцитарную терапию (ДАТТ) в виде ацетилсалициловой кислоты (АСК) 75 мг и клопидогрела 75 мг. Полученные данные обследований (общеклинические, агрегометрии, уровень С-реактивного белка (СРБ), растворимого лиганда CD40, sP-селектина, фактора фон Виллебранда (ФВ), эндотелина-1 (ЭТ-1), эндотелийзависимой вазодилатация (ЭЗВД)) проанализированы с использованием программы «Statistica 10.0». Результаты. Выявлено 45 % пациентов с недостаточным ответом на ДАТТ (ПГ2) и 55 % с нормальным ответом (ПГ1). Уровень ЭТ-1, ФВ и СРБ был выше в ПГ2, по сравнению с ПГ1. ЭЗВД в ПГ1-2,4 [-8,9; 25,0] %, в ПГ2-8,4 [-19,2; 14,1] %, р<0,05. В ПГ2 преобладали пациенты с резко выраженным нарушением функции эндотелия (р=0,024 по точному тесту Фишера). Выводы. ДАТТ, проводимая АСК и клопидогрелем, эффективна у 55 % пациентов со ССН. У 45 % пациентов имеется недостаточный ответ на прием ДАТТ. Лабораторная резистентность к ДАТТ у пациентов со ССН многофакторна и ассоциирована с высокими уров

show abstract

Section: Markers Of Systemic Inflammation and Endothelial Dysfunctionunclassified

Endothelial dysfunction, systemic inflammation, platelet aggregation properties and their relationship in patients with stable stenocardia

Pronko¹,

Снежицкий²,

Шулика³

2020

Regional blood circulation and microcirculation

View full text Add to dashboard Cite

show abstract

“…Снижение функции почек и стойкая следовая протеинурия отмечаются у детей данной группы уже к концу 1-го года жизни. В качестве маркера прогрессирования заболевания можно рассматривать и статистически значимое увеличение у этих детей уровня тромбоцитов, которые вносят существенный вклад не только в систему гемостаза, но также модулируют воспалительные реакции и иммунный ответ, участвуют в процессах склерозирования [32]. УЗ-исследование позволяет на ранних этапах выявлять не только наличие признаков обструктивных нефропатий, но и особенности органной гемодинамики.…”

Section: обсуждение основного результата исследованияunclassified

Features of the course of nephropathies in combination with CAKUT-syndrome in young children

Сафина

Зеленцова

Мышинская

et al. 2020

jour

View full text Add to dashboard Cite

Background. Children with CAKUT-syndrome (congenital malformations of the urinary tract) quickly develop an inflammatory process, which, in combination with dysplasia and/or urodynamic disorders, creates a high risk of developing early chronic renal failure. Purpose of the study: to identify the main factors of the formation, features of the clinical course of nephropathies, morphometric parameters and features of the organ blood flow of the kidneys in young children against the background of CAKUT syndrome. Methods. Study design: It carried out a cohort prospective study. The main group included 26 children with pyelonephritis against the background of CAKUT syndrome at the age from zero to 36 months of life, the comparison group consisted of 29 children with non-obstructive pyelonephritis of the same age. It carried out a comparative analysis of antenatal and postnatal anamnesis, clinical, laboratory and instrumental data in the considered groups of children with nephro-urological pathology. Additionally, it researches the morphometric parameters of the kidneys and the Doppler indices of the renal vessels. The research conducted during 2016-2018. Results. In children with a chronic course of nephropathy in combination with CAKUT-syndrome, possible predictors of an early onset of the disease are: anemia, damage to the urinary tract with pathological urinary syndrome during pregnancy and a combination with defects of this system in the woman herself, and the development of placental insufficiency. In the group with CAKUT syndrome, a decrease in renal filtration function (in 88.5% of children) and persistent trace proteinuria (in 65.4% of children) are recorded by the end of the first year of life. According to ultrasound, in addition to signs of obstructive nephropathy, it recorded decreases in the thickness of the parenchyma and a violation of organ hemodynamics with an increase in the resistance index. In the observed group of children, CAKUT syndrome combined in 100% of cases with connective tissue dysplasia syndrome also. Conclusion. Thus, CAKUT syndrome leads to early realization of nephropathies in children with a rapid decline in renal function.

show abstract

“…Обсуждается первостепенная роль тромбоцитов в патогенезе зaболеваний сердечно-сосудистой системы как модуляторов воспалительных реакций иммунного ответа, которые сегодня рассматриваются в качестве ведущего механизма развития атеросклероза. Провоспалительные цитокины способствуют экспрессии ферментов, приводящих к дестабилизации атеросклеротической бляшки (АСБ) с последующим ее разрывом [6]. После разрывa АСБ макрофаги и гладкомышечные клетки прoдуцируют тканевой фактор, запускающий каскад коагуляции, приводящий к трoмбозу.…”

Section: Introductionunclassified

Proinflammatory biomarkers and platelet aggregation activity in patients with coronary artery disease

Trubacheva,

Kologrivova,

Schnaider

et al. 2024

Bûll. sib. med.

View full text Add to dashboard Cite

Aim. To determine concentrations and identify the relationship of biomarkers (endocan / cell-specific molecule-1, fatty acid binding protein 4 (FABP 4), placental growth factor (PlGF), oncostatin M), with parameters of collageninduced platelet aggregation in patients with coronary artery disease (CAD).Materials and methods. In patients with CAD (n = 51), serum levels of endocan, FABP 4, PlGF, oncostatin M, and platelet aggregation indices (collagen at concentrations of 2 and 10 mmol / l) were determined. Patients were divided into groups with and without high residual platelet reactivity (HRPR). Correlation coefficients between concentrations of proinflammatory biomarkers and platelet aggregation indices were determined in patients of both groups.Results. In patients with HRPR, the concentrations of endocan and PlGF were significantly higher, and the concentrations of FABP4 and oncostatin M were lower than in the first group. In patients with HRPR, a correlation was found between the concentration of endocan and the degree of platelet aggregation in the presence of 2 mmol/ l of collagen (ρ = 0.48; p = 0.01), between the concentration of PlGF and the degree of platelet aggregation in the presence of 10 mmol / l of collagen (ρ = 0.58; p = 0.01), as well as between the concentration of FABP 4 and the size of aggregates at both collagen concentrations (ρ = 0.42; p = 0.03) and (ρ = 0.70; p = 0.01) and the degree of platelet aggregation in the presence of 10 mmol / l of collagen (ρ = 0.43; p = 0.01).Conclusion. In all examined CAD patients, regardless of the residual platelet reactivity, the levels of endocan and FABP 4 increased compared to the reference values. In patients with HRPR, the content of parameters (endocan, PlGF) contributing to plaque growth was elevated, and in patients without HRPR, the levels of platelet-activating factors (FABР 4, oncostatin M) were increased, which determines a personalized approach to prescribing therapy for these groups of patients. In patients with CAD, platelet aggregation indices were associated with concentrations of proinflammatory biomarkers (endocan, PlGF, and FABP 4), which contribute to the development of endothelial dysfunction.

show abstract

The role of platelets in inflammation and immunity

Cited by 10 publications

References 57 publications

Endothelial dysfunction, systemic inflammation, platelet aggregation properties and their relationship in patients with stable stenocardia

Endothelial dysfunction, systemic inflammation, platelet aggregation properties and their relationship in patients with stable stenocardia

Features of the course of nephropathies in combination with CAKUT-syndrome in young children

Proinflammatory biomarkers and platelet aggregation activity in patients with coronary artery disease

Contact Info

Product

Resources

About