The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death

Opländer, Christian; Suschek, Christoph V.

doi:10.3390/ijms14010191

Cited by 37 publications

(26 citation statements)

References 72 publications

(79 reference statements)

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“…This peak also increases with the plasma treatment time t, which is due to the change in the chemical composition inside the solution. In this wavelength range, nitrites NO2 − , nitrates NO3 − [42,43], and hydrogen peroxide H2O2 [44] can contribute to the signal, which indicates their formation in the stock solution during the plasma treatment. As the plasma treatment time t increases, the plasmon resonance signal becomes broader.…”

Section: Form and Position Of The Plasmon Resonance Peakmentioning

confidence: 98%

In Situ Investigation of the Formation Kinematics of Plasma-Generated Silver Nanoparticles

Tasche

Weber

Mrotzek³

et al. 2020

Nanomaterials

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In this publication, it is shown how to synthesize silver nanoparticles from silver cations out of aqueous solutions by the use of an atmospheric pressure plasma source. The use of an atmospheric pressure plasma leads to a very fast reduction of silver ions in extensive solvent volumes. In order to investigate the nanoparticle synthesis process, ultraviolet/visible (UV/VIS) absorption spectra were recorded in situ. By using transmission electron microscopy and by the analysis of UV/VIS spectra, the kinetics of silver nanoparticle formation by plasma influence can be seen in more detail. For example, there are two different sections visible in the synthesis during the plasma exposure process. The first section of the synthesis is characterized by a linear formation of small spherical particles of nearly constant size. The second section is predominated by saturation effects. Here, particle faults are increasingly formed, induced by changes in the particle shape and the fusion of those particles. The plasma exposure time, therefore, determines the shape and size distribution of the nanoparticles.

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Section: Form and Position Of The Plasmon Resonance Peakmentioning

confidence: 98%

In Situ Investigation of the Formation Kinematics of Plasma-Generated Silver Nanoparticles

Tasche

Weber

Mrotzek³

et al. 2020

Nanomaterials

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“…The first two produce transient pico-to nanomolar concentrations of NO and are dependent on intracellular calcium levels, whereas iNOS is calcium-independent and results in long-lasting micromolar concentrations of NO [694]. Some NO results from swallowed nitrite (NO 2 − ), or from nitrites in the UVA or blue light-exposed skin [695]. In sensory neurons, NO plays a very important role in modulating pain sensitivity during inflammation [696,697], as confirmed by the analgesic effect of NO synthesis inhibitors [698].…”

Section: Free Radicals In Inflammationmentioning

confidence: 99%

Novel Analgesics with Peripheral Targets

Ciotu

Fischer

2020

Neurotherapeutics

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A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory process, of which an analgesic effect secondary to an anti-inflammatory effect can be expected. Different approaches to address these systems are discussed, including scavenging proinflammatory mediators, applying anti-inflammatory mediators, and inhibiting proinflammatory or facilitating anti-inflammatory receptors. New approaches are contrasted to established ones; the current stage of progress is mentioned, in particular considering whether there is data from a molecular and cellular level, from animals, or from human trials, including an early stage after a market release. An overview of publication activity is presented, considering a IuPhar/BPS-curated list of targets with restriction to pain-related publications, which was also used to identify topics.

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“…On the one hand, the exposure of skin to UVB (280‐320 nm) is carcinogenic and promotes oxidative stress and ROS interacting directly with DNA . On the other hand, by interaction with non‐DNA chromophores such as cellular photosensitizers, UVA (320‐400 nm) generates ROS and induces oxidative stress and injuries in human skin . Thus, a number of deleterious effects can be caused by these direct and indirect injuries.…”

Section: Introductionmentioning

confidence: 99%

“…3 On the other hand, by interaction with non-DNA chromophores such as cellular photosensitizers, UVA (320-400 nm) generates ROS and induces oxidative stress and injuries in human skin. 4 Thus, a number of deleterious effects can be caused by these direct and indirect injuries. These effects include disruptions and alterations of the regulation pathways and cell metabolism, differentiation, proliferation, and apoptosis of skin cells.…”

mentioning

confidence: 99%

Study of antioxidant properties of thylakoids and application in UV protection and repair of UV‐induced damage

St-Pierre

Blondeau

Boivin

et al. 2019

J of Cosmetic Dermatology

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Background Skin is affected by environmental stress such as ultraviolet exposure. Topically applied antioxidants confer protection against this stress. Spinach thylakoid extracts are plant samples known as photosynthetic membranes containing antioxidant molecules able to dissipate excess of energy and oxidative stress. Methods Antioxidant contents and activities were tested in thylakoid extracts stored for different periods at 4°C to compare their efficacities. Cytotoxicity of thylakoids was tested on human THP‐1 cells along with the capacity to protect from oxidative stress using flow cytometry. Protection of thylakoids against ultraviolet was tested on engineered human skin using two formulations and evaluated by electronic microscopy. Results Results indicate that thylakoid extracts possess antioxidant molecules that were not significantly affected by storage at 4°C whereas photosynthetic activity was storage‐dependent. Thylakoid extracts were not cytotoxic to human THP‐1 cells, and three extracts protected cells against reactive oxygen species. Moreover, formulation comprising 0.1% or 0.01% of thylakoids and sunscreen provided a synergetic protection against UV exposure. Thylakoid extracts mixed with a neutral cream were also able to repair UV damages on engineered human skin. Conclusions Thylakoid extracts contained various antioxidant molecules, and their properties were maintained in over storage at 4°C for more than 72 months. Molecules and enzymes present in thylakoid extracts are involved in protecting and restoring the harmful effects of UV exposure. The involvement of antioxidant molecules such as carotenoids, SOD, and Fe‐S clusters in cellular and regulatory metabolic reactions may explain the observed protective effects.

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The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death

Cited by 37 publications

References 72 publications

In Situ Investigation of the Formation Kinematics of Plasma-Generated Silver Nanoparticles

In Situ Investigation of the Formation Kinematics of Plasma-Generated Silver Nanoparticles

Novel Analgesics with Peripheral Targets

Study of antioxidant properties of thylakoids and application in UV protection and repair of UV‐induced damage

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