The role of peritumoural brain edema in ascertaining the high risk meningiomas

Butta, Shristi; Gupta, Manoj Kumar; Sandeep, B; Pal, Mallika; Saha, Suniti Kumar

doi:10.18203/2320-6012.ijrms20204882

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Many studies have showed that PTBE was significantly associated with recurrence in meningiomas [22,23]. Furthermore, sphenoid ridge and parasagittal meningiomas, represented the most common locations for recurrent in one study, and both of them had preoperative PTBE in all cases [24].…”

Section: Discussionmentioning

confidence: 79%

Recurrence rate of sphenoid wing meningiomas and role of peritumoural brain edema: a single center retrospective study

Nassar

Smolanka

et al. 2021

Ukr Neurosurg J

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Objective: To evaluate the recurrence rate of the operatively treated sphenoid wing meningiomas (SWMs) in relation to other factors and role of PTBE in recurrence as a prognostic factors in a series of 67 patients. Materials and methods: The magnetic resonance imaging (MRI), and pathology data for 67 patients with SWM, who underwent surgery at Uzhhorod Regional Neurosurgical Center between 2007 and 2021 were examined. The recurrence rate and role of PTBE in recurrence in relation to: gender, age, extend of resection, histopathology, tumor volume, location and time of recurrence were evaluated. Follow-up period ranged from 6 to 168 months (median, 87 months) after surgical resection. Results: In our study, the mean age of patients is 47 years, ranged (20-74), at the average (53.5). Male 16 (23.9%), female 51 (76.1%). Mean tumor volume was (32.8cm3), ranged 4.2cm3-143.7cm3. Edema Index (EI) 1; 27 (40.3%) absent edema, and (EI) >1; in 40 (59.7%) present edema. Recurrence rate was 11 (16.4%) patients, 8 (20.0%) patients with PTBE, as compared to 3 (11.1%) patients without PTBE, (p=0,50). Female (8 patients, 15.7%), male (3 patients, 18.7%). The mean age of recurrence was 50.9 years, ranged (21-75), at the average 52.0 years. The mean age in female was 50.8 years, in male 51.0. Bivariate analysis of simultaneous effect of gender and age on SWM recurrence with logistic regression yield both main effect and interaction effect (β gender=M=7.56±6.44, P=0.24; β age=-0.034±0.031, p=0.28; β interaction term=-0.13±0.12, p=0.26). Out of 11 recurrence cases, (2 cases, 9.5%) with small tumour volume, (5 cases, 15.6%) with medium, (3 cases, 33.3%) with large, and (one case, 20.0%) with giant tumour volume. The effect of tumour volume on recurrence rate is insignificant, χ2=2.42, p=0.49.Location of SWM; the recurrence was in (6 cases, 25.0%) of CM location, (2 cases, 25.0%) of SOM and (3 cases, 11.5%) in lateral SWM, (p=0.19). Pathological grade, in the low grade (Gr.I) 7 recurrence cases (13.0%), as compared to 4cases (44.4%) in atypical Gr II, (p=0.01). Simpson grade, the recurrence rate was; 0% in Gr. I; 13.9% in Gr. II; 20.0% in Gr.III; and 33.3% in Gr. IV and 3 cases had died in the early post op (p<0.05). Conclusion: The factors which had a strong impact on the recurrence rate in our study,; i) pathological grade (Gr. II, atypical type) p=0.01 and ii) Simpson grade (extend of tumor resection, p<0.05), while, PTBE (P=0.50), tumor volume (χ2=2.42, p=0.49) and location (χ2=3.37, p=0.19), are weak and non strong factors for recurrence. However, time of recurrence is shorter in patients with PTBE (W=20.5, p=0.092). WHO Gr. II (Spearman’s p=-0.86, p=0.00063) and negligible for Simpson grade (Spearman’s=-0.15, p=0.66).

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Section: Discussionmentioning

confidence: 79%

Recurrence rate of sphenoid wing meningiomas and role of peritumoural brain edema: a single center retrospective study

Nassar

Smolanka

et al. 2021

Ukr Neurosurg J

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“…Grading based on histopathology has shown limitations in determining the disease prognosis as not only grade II and III meningiomas but a group of grade I meningiomas have also shown recurrence following surgery and subsequent resistance to radiotherapy. This has therefore demanded for the need of immunohistochemical markers which can ascertain tumor prognosis [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

HIF 1 ɑ – a promising target for the treatment of meningiomas

Butta

Gupta

2023

Medicine and Pharmacy Reports

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Background. Meningiomas are the most frequent tumors of the brain and spinal cord with a potency to recur in around one third of the cases and and invade surrounding tissue. Hypoxia driven factors like HIFs (Hypoxia inducible factors) are implicated in tumor cell growth and proliferation. Aim. This study aims at determining the association of HIF 1 ɑ with different histopathological grades and types of meningiomas. Methods. This prospective study was conducted on 35 patients. The patients presented with headache (65.71%), seizures (22.86%) and neurological deficits (11.43%). They underwent surgical excision and surgical tissue samples of these patients were histopathologically processed and microscopically graded and typed. Immunohistochemistry was performed using anti-HIF 1ɑ monoclonal antibody. The nuclear expression of HIF 1 ɑ was graded as <10%: negative, 11-50%: mild to moderate positive, >50%: strong positive. Results. Of the 35 cases so examined 20% were recurrent; 74.29% were WHO grade I with meningothelial type (22.86%), being the commonest; 57.14 % revealed mild to moderate positivity for HIF 1ɑ, while strong positivity was noted in 28.57%. Significant association was found between WHO grade and HIF 1ɑ (p=0.0015) and between histopathological types and HIF 1ɑ (p=0.0433). Furthermore, HIF 1ɑ was also significantly associated with the recurrent cases (p=0.0172). Conclusion. HIF 1ɑ appears to be a marker and a promising target for effective therapeutics in meningiomas

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The role of peritumoural brain edema in ascertaining the high risk meningiomas

Cited by 2 publications

References 37 publications

Recurrence rate of sphenoid wing meningiomas and role of peritumoural brain edema: a single center retrospective study

Recurrence rate of sphenoid wing meningiomas and role of peritumoural brain edema: a single center retrospective study

HIF 1 ɑ – a promising target for the treatment of meningiomas

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