HIF 1 ɑ – a promising target for the treatment of meningiomas

Abstract

Background. Meningiomas are the most frequent tumors of the brain and spinal cord with a potency to recur in around one third of the cases and and invade surrounding tissue. Hypoxia driven factors like HIFs (Hypoxia inducible factors) are implicated in tumor cell growth and proliferation.
 Aim. This study aims at determining the association of HIF 1 ɑ with different histopathological grades and types of meningiomas.
 Methods. This prospective study was conducted on 35 patients. The patients presented with headache (65.71%), seizures (22.86%) and neurological deficits (11.43%). They underwent surgical excision and surgical tissue samples of these patients were histopathologically processed and microscopically graded and typed. Immunohistochemistry was performed using anti-HIF 1ɑ monoclonal antibody. The nuclear expression of HIF 1 ɑ was graded as <10%: negative, 11-50%: mild to moderate positive, >50%: strong positive.
 Results. Of the 35 cases so examined 20% were recurrent; 74.29% were WHO grade I with meningothelial type (22.86%), being the commonest; 57.14 % revealed mild to moderate positivity for HIF 1ɑ, while strong positivity was noted in 28.57%. Significant association was found between WHO grade and HIF 1ɑ (p=0.0015) and between histopathological types and HIF 1ɑ (p=0.0433). Furthermore, HIF 1ɑ was also significantly associated with the recurrent cases (p=0.0172).
 Conclusion. HIF 1ɑ appears to be a marker and a promising target for effective therapeutics in meningiomas

Role of Arctiin in Fibrosis and Apoptosis in Experimentally Induced Hepatocellular Carcinoma in Rats

“…This binding activates the transcription of genes that help cells adapt to low oxygen conditions, including those involved in angiogenesis, glucose metabolism, and apoptosis. In addition to its role in hypoxia, HIF-1α also plays a critical role in cancer progression by promoting tumorigenicity and angiogenesis [ 18 ]. Interestingly, HIF-1α protein is almost undetectable in normal cells under normoxic conditions, whereas it is highly activated in many tumors.…”

Effects of Echinacoside on Ehrlich Carcinoma in Rats by Targeting Proliferation, Hypoxia and Inflammation

“…During hypoxia, HIF-1α moves into the nucleus and helps the cell adjust its metabolism to the new conditions by linking to DNA [ 19 ]. In normal cells, HIF-1α is present in small amounts, but it is highly activated in many tumors [ 20 ]. Our research discovered that HIF-1α expression increased significantly in ESC cells but was downregulated after echinacoside treatment.…”