The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis: a systematic review and meta-analysis

Ju, Jun; Li, Yun; Chai, Jinxiang; Ni, Qianwei; Shen, Zhiyuan; Wei, Jianhua; Sun, Miao

doi:10.1016/j.oooo.2016.08.008

Cited by 47 publications

(33 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study, we showed that PNI correlates with a poor prognosis in adenoid cystic carcinoma. 13 However, the molecular mechanisms governing SACC PNI are poorly understood. Recent evidence has supported that signaling between tumor and nerve cells through ligand-receptor interactions, such as chemokines and their receptors, might be involved in PNI of SACC.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma

Gao

Shen

et al. 2018

Journal of Oral and Maxillofacial Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…12 Perineural growth in SACC might be associated with increased locoregional recurrence after tumor resection and decreased disease-free survival. 13 However, little progress has been made in uncovering the pathogenesis of PNI in SACC, and the reciprocal SACC cell-nerve interaction has not yet been elucidated.…”

mentioning

confidence: 99%

The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma

Gao

Shen

et al. 2018

Journal of Oral and Maxillofacial Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…In another study, Jang et al demonstrated that SACC with PNI subsequently progressed to metastasis, while no distant metastasis was observed in those without PNI (13). Multivariate analysis revealed that PNI was a significant predictive factor in distant metastasis (14). These results indicate that PNI potentiates distant metastatic progression, thus influencing patient outcomes.…”

Section: Introductionmentioning

confidence: 96%

Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go

et al. 2020

View full text Add to dashboard Cite

Adenoid cystic carcinoma of the salivary gland (SACC) is a rare malignant tumors of the head and neck region, but it is one of the most common malignant tumors that are prone to perineural invasion (PNI) of the head and neck. The prognosis of patients with SACC is strongly associated with the presence of perineural spread (PNS). Although many contributing factors have been reported, the mechanisms underlying the preferential destruction of the blood-nerve barrier (BNB) by tumors and the infiltration of the tumor microenvironment by nerve fibers in SACC, have received little research attention. This review summarizes the current knowledge concerning the characteristics of SACC in relation to the PNI, and then highlights the interplay between components of the tumor microenvironment and perineural niche, as well as their contributions to the PNI. Finally, we provide new insights into the possible mechanisms underlying the pathogenesis of PNI, with particular emphasis on the role of extracellular vesicles that may serve as an attractive entry point in future studies.

show abstract

“…ACC constitutes 10% of salivary gland tumors and approximately 1% of head and neck tumors [4]. ACC progresses slowly but has a high rate of perineural invasion, local recurrence, and indolent distant metastasis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Keam

Ock

et al. 2021

Korean J Intern Med

View full text Add to dashboard Cite

Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC. Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached). Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.

show abstract

The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis: a systematic review and meta-analysis

Cited by 47 publications

References 36 publications

The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma

The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma

Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Contact Info

Product

Resources

About