The role of pentraxin-3 as a prognostic biomarker in paraquat poisoning

Yeo, Chang Dong; Kim, Jin-Woo; Kim, Young‐Ok; Yoon, Sun-Ae; Kim, Kwan-Hyoung; Kim, Youngsoo

doi:10.1016/j.toxlet.2011.12.007

Cited by 19 publications

(13 citation statements)

References 32 publications

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“…We found NLR, leukocyte and neutrophil counts may also be excellent prognostic predictors for acute PQ poisoning. Thirdly, several potential prognostic predictors recently have been indicated have prognostic value in acute PQ poisoning, including serum uric acid28, serum amylase activity29, plasma PTX330, arterial lactate level and lactate metabolic clearance rate7, arterial blood gas analysis31, and so on. In contrast to those potential prognostic predictors, our present stduy have several advantages: 1) our results indicated NLR, leukocyte and neutrophil counts, may be have even better sensitivity and specificity by ROC analysis; 2) the complete blood count is a routine detection in hematological parameters, when patients presenting with acute poisoning to the emergency department; 3) it is important to note that the test results of complete blood count are usually quick, inexpensive and realized in almost all hospital, including local hospitals.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of hematological parameters in patients with paraquat poisoning

Zhou

Zhang

Luo

et al. 2016

Sci Rep

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Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors. In the receiver operating characteristic (ROC) curve analysis, the NLR had an area of 0.916(95%CI, 0.877–0.954) and the optimal cut-off value was 10.57 (sensitivity, 86.70%; specificity, 83.51%; Youden’s index, 0.702). The leukocyte counts had an area of 0.849(95%CI, 0.796–0.902) and the optimal cut-off value was 13.15 × 103/mm3 (sensitivity, 77.10%; specificity, 83.50%; Youden’s index, 0.606). The neutrophil counts had an area of 0.878(95%CI, 0.830–0.925) and the optimal cut-off value was 10.10 × 103/mm3 (sensitivity, 83.80%; specificity, 79.38%; Youden’s index, 0.632). NLR, leukocyte and neutrophil counts are associated with the 30-day mortality, which may be useful and simple parameters in predicting the prognosis of PQ poisoning.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of hematological parameters in patients with paraquat poisoning

Zhou

Zhang

Luo

et al. 2016

Sci Rep

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“…Serum uric acid and the acutephase response gene pentraxin 3 (PTX3) were recently characterized and highlighted as putative biomarkers for PQ poisoning in human serum (14,15). However, the protocols for diagnosis, prognosis, and treatment of PQ-poisoned patients are limited.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of changes in protein expression in serum from animals exposed to paraquat

Kim

Jung

Gil

et al. 2012

International Journal of Molecular Medicine

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Abstract. Paraquat (PQ) poisoning remains a major public health concern in many countries. Extensive research has focused on finding early diagnostic biomarkers of acute PQ poisoning. In order to investigate the characterization of diagnostic biomarkers in PQ poisoning, we utilized proteomic analysis using serum from rats exposed to PQ, and we identified 8 differentially expressed proteins from over 500 protein spots. The expression of apolipoprotein E (ApoE), preprohaptoglobin (Pphg), a precursor of haptoglobin (Hp), and complement component 3 (C3) proteins was greatly induced by PQ exposure while the expression of fibrinogen γ-chain (FGG) and Ac-158 was dramatically reduced. To further investigate the possibility of ApoE, Pphg and FGG as useful diagnostic biomarkers of PQ poisoning, western blot and qRT-PCR analyses were conducted using cell lines as well as rat and human sera. The expression levels of ApoE, Hp and FGG were significantly altered in the presence of PQ in both rat and human serum suggesting that these proteins may be appropriate candidate molecular biomarkers for the early diagnosis of acute PQ intoxication.

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“…The principal biochemical mechanism of PQ poisoning is based on redox cycling and intracellular oxidative stress generation, and pulmonary fibrosis and edema are the major clinical symptoms (7). A previous study has investigated various treatment modalities for acute PQ poisoning, but the fatality rate remains high (8). In this context, biomarkers for the prognosis and clinical monitoring of acute PQ poisoning are urgently required to guide appropriate treatment plans and develop future PQ antidotes (2).…”

Section: Introductionmentioning

confidence: 99%

Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning

Liu

et al. 2017

Experimental and Therapeutic Medicine

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The present study investigated the predictive values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and Acute Physiology and Chronic Health Evaluation (APACHE) II score in the prognosis of patients with acute PQ poisoning. A total of 194 patients with acute PQ poisoning, hospitalized between April 2012 and January 2014 at the First Affiliated Hospital of P.R. China Medical University (Shenyang, China), were selected and divided into survival and mortality groups. Logistic regression analysis, receiver operator characteristic (ROC) curve analysis and Kaplan-Meier curve were applied to evaluate the values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and (APACHE) II score for predicting the prognosis of patients with acute PQ poisoning. Initial urine PQ concentration (C0), dose of poison, arterial blood lactate and APACHE II score of patients in the mortality group were significantly higher compared with the survival group (all P<0.05). Logistic regression analysis revealed that C0, dose of poison and arterial blood lactate correlated with mortality risk of acute PQ poisoning (all P<0.05). ROC curve analysis suggested that the areas under the curve (AUC) values of C0, dose of poison, arterial blood lactate and APACHE II score in predicting the mortality of patients within 28 days were 0.921, 0.887, 0.808 and 0.648, respectively. The AUC of C0 for predicting early and delayed mortality were 0.890 and 0.764, respectively. The AUC values of urine paraquat concentration the day after poisoning (Csec) and the rebound rate of urine paraquat concentration in predicting the mortality of patients within 28 days were 0.919 and 0.805, respectively. The 28-day survival rate of patients with C0 ≤32.2 µg/ml (42/71; 59.2%) was significantly higher when compared with patients with C0 >32.2 µg/ml (38/123; 30.9%). These results suggest that the initial urine PQ concentration may be the optimal index for predicting the prognosis of patients with acute PQ poisoning. Additionally, dose of poison, arterial blood lactate, Csec and rebound rate also have referential significance.

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The role of pentraxin-3 as a prognostic biomarker in paraquat poisoning

Cited by 19 publications

References 32 publications

Prognostic value of hematological parameters in patients with paraquat poisoning

Prognostic value of hematological parameters in patients with paraquat poisoning

Proteomic analysis of changes in protein expression in serum from animals exposed to paraquat

Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning

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