Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning

Liu, Xiao‐Wei; Ma, Tao; Li, Lulu; Liu, Zhi

doi:10.3892/etm.2017.4463

Cited by 18 publications

(16 citation statements)

References 21 publications

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“…The present study also found that APACHE II score and ingestion amount of PQ both had significant differences between the survivors and deaths. And ROC curve analysis revealed their prognostic values after PQ poisoning, which were in accordance with some previous studies that APACHE II score and ingestion amount of PQ had good prognostic values for acute PQ poisoning 15 – 18 . Moreover, Vmax may have a better predictive power than APACHE II score and ingestion amount of PQ by comparison of the AUC values.…”

Section: Discussionsupporting

confidence: 90%

Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients

Feng

Yu-ning

Ruan

et al. 2018

Sci Rep

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This retrospective and a single-center study evaluated the prognostic value of the maximum serum creatinine value (maxCr) and the maximum serum creatinine growth rate (Vmax) after paraquat (PQ) ingestion. One hundred and seventy-one patients with PQ poisoning were treated with a uniform protocol. Demographic variables, clinical manifestations, relevant laboratory data, maxCr and Vmax of all patients were recorded and calculated. The time after PQ ingestion of maxCr and Vmax were also recorded. Vmax and MaxCr exhibited statistically significant differences between the survivor (n = 53) and death (n = 118) groups. Vmax appeared earlier in the death group than the survivor group. Regard to the receiver operating characteristic (ROC) curve analysis, Vmax had an AUC of 0.861 (95% CI, 0.801–0.921) and the optimal cut-off value of 6.21 μmol/(L·h) (sensitivity, 76.3%; specificity, 81.1%). MaxCr had an area under the curve (AUC) of 0.821 (95% CI, 0.752–0.889) and the optimal cut-off value of 225.5 µmol/L (sensitivity, 82.2%; specificity, 67.9%). The comparison of the AUC in the two parameters showed no significant difference, but Vmax appeared earlier than maxCr. Based on binary logistic regression analysis, MaxCr and Vmax both showed strong predictive powers for evaluating the prognosis of acute PQ poisoning patients.

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Section: Discussionsupporting

confidence: 90%

Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients

Feng

Yu-ning

Ruan

et al. 2018

Sci Rep

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“…Generally, plasma and urea PQ concentrations, and the amount of oral poisoning are the most remarkable prognostic indices. 25 However, plasma and urea PQ concentrations change at different time intervals after ingestion, and any uncertainty on ingestion time can result in uncertainty of survival estimates. 13 Only a few hospitals are capable of detecting plasma and urea PQ concentrations.…”

Section: Discussionmentioning

confidence: 99%

Hyperamylasemia as an early predictor of mortality in patients with acute paraquat poisoning

et al. 2020

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This study aimed to evaluate the relationship between elevated serum amylase levels and the prognosis of paraquat poisoning. Methods: Patients were categorized into the elevated and non-elevated serum amylase groups according to serum amylase levels. Demographics, mortality, risk factors of elevated serum amylase levels, and injury to the pancreas were analyzed. Results: A total of 457 patients were enrolled in this study and the overall mortality rate was 51.9%. Patients in the elevated group had worse indices than those in the non-elevated group. Kaplan-Meier survival analysis showed that the mortality rate in the elevated group was significantly higher than that in the non-elevated group (hazard ratio: 10.65, 95% confidence interval [CI]: 7.55-15.02). Multivariate Cox proportional hazards analysis showed that elevated serum amylase levels were related to mortality (hazard ratio: 2.066, 95% CI: 1.239-3.444). The receiver operating characteristic curve showed that the area under the curve was 0.724 (95% CI: 0.666-0.783) for serum amylase levels with 70.4% sensitivity and 74.0% specificity. Conclusion: Elevated serum amylase levels are observed in PQ poisoning. This elevation might be one of the most accurate early prognostic factors for predicting severity and mortality.

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“…Another important predictor of mortality is the oral dose of the poison. [ 5 ] Unfortunately, estimates on the amount ingested are often unobtainable or unreliable in a number of intoxicated patients. The use of Acute Physiology and Chronic Health Evaluation II, [ 5 , 19 ] Sequential Organ Failure Assessment, [ 3 ] and machine-learning methods [ 20 ] to prognosticate patients with PQ poisoning by combining coagulation, liver, and kidney indices can provide a perfect predictive value for the outcome of PQ poisoning.…”

Section: Discussionmentioning

confidence: 99%

Serum anion gap at admission as a predictor of the survival of patients with paraquat poisoning

Zhao¹,

Feng²,

Li³

2020

Medicine

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Paraquat (PQ) poisoning is associated with high mortality rate. Therefore, an accurate method for predicting the survival of patients with PQ poisoning is required. This study evaluated the value of serum anion gap (AG) at admission in predicting the survival of such patients. Cases of patients with PQ poisoning admitted to Cangzhou Central Hospital between May 2012 and March 2019 were retrospectively analyzed. The patients were classified into survival and nonsurvival groups on the basis of their 90-day prognosis. Correlation analysis, Cox regression analysis, and receiver operating characteristic and Kaplan–Meier curve analyses were performed to assess the value of AG in predicting the 90-day survival of patients with PQ poisoning. Only 44 of the 108 patients with PQ poisoning survived; thus, the 90-day survival was 40.74%. AG levels at admission were significantly higher in nonsurvivors (26.53 ± 4.93 mmol/L) than in survivors (20.88 ± 2.74 mmol/L) ( P < .001) and negatively correlated with 90-day survival ( r = −0.557; P < .001). Cox regression analysis revealed that AG at admission is an independent prognostic marker of the 90-day survival of patients with PQ poisoning. AG level at admission had an area under the receiver operating characteristic curve of 0.836 (95% confidence interval: 0.763–0.909) and an optimal cut-off value of 25.5 mmol/L (59.4% sensitivity and 95.5% specificity). AG level at admission may serve as a candidate marker for predicting the survival of patients with PQ poisoning.

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Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning

Cited by 18 publications

References 21 publications

Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients

Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients

Hyperamylasemia as an early predictor of mortality in patients with acute paraquat poisoning

Serum anion gap at admission as a predictor of the survival of patients with paraquat poisoning

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