The role of ‘passive chemotherapy’ plus health education for schistosomiasis control in China during maintenance and consolidation phase

Guo, Jing; Cao, Chen; GuangHan, Hu; Han, Lin; Dong, Li; Zhu, Rong; Xu, Jing

doi:10.1016/j.actatropica.2005.07.012

Cited by 41 publications

(57 citation statements)

References 18 publications

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“…As scaling up integrated control moves forward, a number of research and monitoring questions will need to be addressed, including issues of compliance [ 51], drug interactions, emerging drug resistance [ 52], and sustainability. Moreover, proof of concept for the feasibility of integrated control will require attention to the specific populations (e.g., children versus adults) at risk for each of the neglected tropical diseases, and to the timing for administration of each of the four drugs.…”

Section: Epidemiologic Overlap and Comorbidity Of The Neglected Tropimentioning

confidence: 99%

Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria

Hotez¹,

Molyneux²,

Fenwick³

et al. 2006

PLoS Med

690

576

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Section: Epidemiologic Overlap and Comorbidity Of The Neglected Tropimentioning

confidence: 99%

Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria

Hotez¹,

Molyneux²,

Fenwick³

et al. 2006

PLoS Med

690

576

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“…28 Behavioural changes brought on by recent improvements in health awareness may also have reduced the prevalence, particularly in females. 29 Approximately 90% of houses in the region have an adequate water supply, reducing the exposure of women to schistosome-contaminated lake and marshland areas. 30 However, fishing and farming, the two most common male occupations in the region, require frequent lake-water exposure and close interaction with animal hosts.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China

Balen

Zhao

Williams

et al. 2007

Bull World Health Organ

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Objective To determine the prevalence and intensity of Schistosoma japonicum infection and associated morbidity, and to estimate the infected human and buffalo populations in the Dongting Lake region, Hunan province, China. Methods We used data from the third national schistosomiasis periodic epidemiological survey (PES) of 2004. These included 47 144 human serological and 7205 stool examinations, 3893 clinical examinations and questionnaire surveys, and 874 buffalo stool examinations, carried out in 47 villages in Hunan province. Serological examinations were performed using the enzyme linked immunosorbent assay technique and human stool samples were examined by the Kato-Katz method. Stools from buffaloes and other domestic animals were examined for schistosome infection by the miracidial hatching test. Findings Sero-prevalence was 11.9% (range: 1.3-34.9% at the village level), and the rate of egg-positive stools was estimated at 1.9% (0-10.9%) for the same population. The prevalence of infection among buffaloes was 9.5% (0-66.7%). Extrapolating to the entire population of the Dongting Lake region, an estimated 73 225 people and 13 973 buffaloes were infected. Most frequently reported symptoms were abdominal pain (6.2%) and bloody stools (2.7%). More than half of the clinically examined people reported having had at least one prior antischistosomal treatment. Conclusion There was a significant reduction in the number of humans infected with S. japonicum since the previous national PES carried out in 1995, partially explained by large-scale chemotherapy campaigns. However, a near-stable number of buffalo infections suggest continuing human re-infection, which may lead to future increases in human prevalence.

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“…A solid governmental strategy must integrate diagnosis and treatment into the primary healthcare system. In China, the benefit of this integration was clearly demonstrated by Guo et al 104 , who reported that the cost of a strategy based on passive chemotherapy and health education was approximately half the cost of mass drug distribution in two villages with 11% and 12.3% prevalence of S. mansoni infection, with similar treatment coverage.…”

mentioning

confidence: 89%

Diagnosing schistosomiasis: where are we?

Gomes

Enk

Rabello

2014

Rev. Soc. Bras. Med. Trop.

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In light of the World Health Organization's initiative to extend schistosomiasis morbidity and mortality control programs by including a disease elimination strategy in low endemic settings, this paper reviews diagnostic tools described during the last decades and provide an overview of ongoing efforts in making an efficient diagnostic tool available worldwide. A literature search on PubMed using the search criteria schistosomiasis and diagnosis within the period from 1978 to 2013 was carried out. Articles with abstract in English and that used laboratory techniques specifically developed for the detection of schistosomiasis in humans were included. Publications were categorized according to the methodology applied (parasitological, immunological, or molecular) and stage of development (in house development, limited field, or large scale field testing). The initial research generated 4,535 publications, of which only 643 met the inclusion criteria. The vast majority (537) of the publications focused on immunological techniques; 81 focused on parasitological diagnosis, and 25 focused on molecular diagnostic methods. Regarding the stage of development, 307 papers referred to in-house development, 202 referred to limited field tests, and 134 referred to large scale field testing. The data obtained show that promising new diagnostic tools, especially for Schistosoma antigen and deoxyribonucleic acid (DNA) detection, which are characterized by high sensitivity and specificity, are being developed. In combination with international funding initiatives these tools may result in a significant step forward in successful disease elimination and surveillance, which is to make efficient tests accessible and its large use self-sustainable for control programs in endemic countries.

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The role of ‘passive chemotherapy’ plus health education for schistosomiasis control in China during maintenance and consolidation phase

Cited by 41 publications

References 18 publications

Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria

Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria

Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China

Diagnosing schistosomiasis: where are we?

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