The role of oxygen-increased respirator in humans ascending to high altitude

Shen, Guanghao; Xie, Kangning; Yan, Yishu; Jing, Da; Tang, Chi; Wu, Xinying; Liu, Juan; Sun, Tao; Zhang, Jianbao; Luo, Erping

doi:10.1186/1475-925x-11-49

Cited by 11 publications

(12 citation statements)

References 18 publications

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“…In a hypobaric chamber, as the altitude increases, the air pressure in the cabin and the oxygen partial pressure decrease. Atmospheric pressure is inversely related to altitude because the level of oxygen at high altitude is decreased [33] . The decreased partial pressure of oxygen reduces the ability of hemoglobin to carry oxygen in the blood and for oxygen to dissociate from HbO 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is a lack of oxygen in the body, and hypoxia occurs. As a result, the partial pressure of oxygen, the product of the fractional concentration of oxygen and the overall pressure, is the key factor in AMS [33] . Additionally, peripheral chemoreceptors (located in the carotid and aortic bodies) can sense the decreased PO 2 or increased PCO 2 in the arterial blood.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Visual Analog Score (VAS) to Assess Acute Mountain Sickness (AMS) in a Hypobaric Chamber

Chen

Luo

2014

PLoS ONE

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ObjectiveThe visual analog score (VAS) is widely used in clinical medicine to evaluate the severity of subjective symptoms. There is substantial literature on the application of the VAS in medicine, especially in measuring pain, nausea, fatigue, and sleep quality. Hypobaric chambers are utilized to test and exercise the anaerobic endurance of athletes. To this end, we evaluated the degree of AMS using the visual analog scale (VAS) in a hypobaric chamber in which the equivalent altitude was increased from 300 to 3500 m.MethodsWe observed 32 healthy young men in the hypobaric chamber (Guizhou, China) and increased the altitude from 300 to 3500 m. During the five hours of testing, we measured the resting blood oxygen saturation (SaO2) and heart rate (HR). Using the VAS, we recorded the subjects' ratings of their AMS symptom intensity that occurred throughout the phase of increasing altitude at 300 m, 1500 m, 2000 m, 2500 m, 3000 m, and 3500 m.ResultsDuring the phase of increasing altitude in the hypobaric chamber, the patients' SaO2 was 96.8±0.8% at 300 m and 87.5±4.1% at 3500 m (P<0.05) and their HR was 79.0±8.0 beats/minute at 300 m and 79.3±11.3 beats/minute at 3500 m. The incidence of symptoms significantly increased from 21.9% at an altitude of 1000 m to 65.6% at an altitude of 3500 m (P<0.05). The composite VAS score, which rated the occurrence of four symptoms (headache, dizziness, fatigue, and gastrointestinal discomfort), was significantly correlated with elevation (P<0.01).ConclusionBased on the experimental data, the VAS can be used as an auxiliary diagnostic method of Lake Louise score to evaluate AMS and can show the changing severity of symptoms during the process of increased elevation in a hypobaric chamber; it also reflects a significant correlation with altitude.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of the Visual Analog Score (VAS) to Assess Acute Mountain Sickness (AMS) in a Hypobaric Chamber

Chen

Luo

2014

PLoS ONE

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“…The research on the artificial oxygen-supply technology for the plateau area mainly focused on the oxygen production method and the optimization design of the oxygen enrichment device. The portable oxygen enrichment device for individuals [ 22 ] improved the previous oxygen-increased respirator [ 24 ] using oxygen enrichment membrane to obtain a suitable concentration of oxygen, which can not only increase the level of SpO 2 and physical capacity but also reduce the heart rate. The hyperbaric oxygen chamber [ 25 ] is capable of compressing air pressure in the oxygen chamber to three times absolute atmospheric pressure and can be used to treat acute mountain sickness.…”

Section: Introductionmentioning

confidence: 99%

Study on the Oxygen Enrichment Effect of Individual Oxygen-Supply Device in a Tunnel of Plateau Mine

2020

IJERPH

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Complex characteristics of the plateau environment such as low oxygen content seriously restrict the exploitation of abundant mineral resources in plateau areas. To regulate the hypoxia environment and improve the comfort of workers engaged in intense physical labor like tunnel excavation operations in plateau mines, an individual oxygen-supply device for tunnel of plateau mine was proposed to create local oxygen enrichment in the area around the human nose. The Computational Fluid Dynamics (CFD) method was used to judge the application’s effect of the individual oxygen-supply device in plateau mine, revealing the oxygen diffusion law under the influence of different oxygen enrichment factors. The orthogonal design and range analysis were used to measure the degree of influence of major factors such as oxygen-supply velocity, oxygen-supply concentration, and tunnel airflow velocity. The results demonstrate that the oxygen mass fraction of the air inhaled by the human had a positive correlation exponential function, a positive correlation linear function, and a negative correlation exponential function, respectively, concerning oxygen-supply velocity, oxygen-supply concentration, and tunnel airflow velocity. The range analysis revealed that the major influencing factors of oxygen enrichment in the tunnel of the plateau mine were, in a descending sequence, as follows: oxygen-supply concentration, tunnel airflow velocity, and oxygen-supply velocity, and the corresponding ranges were 2.86, 2.63, and 1.83, respectively. The individual oxygen-supply device achieved the best oxygen enrichment effect when the oxygen-supply velocity was 5 m/s, the oxygen-supply concentration was 60%, and the tunnel airflow velocity was 0.2 m/s, which increased the oxygen mass fraction of air inhaled by the human to 30.42%. This study has a positive guiding significance for the improvement of the respiration environment in the tunnel of plateau mine.

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“…The effectiveness of oxygen supplementation in augmenting arterial blood oxygen levels (5,23,25) could have contributed to hyperoxia supplements, gaining popularity in the ergogenic aid market. A search on Google for the term "Personal Oxygen Supplement" revealed at least 10 companies in the United States marketing small cylinders of 90-95% oxygen for the purposes of enhancing sport performance.…”

Section: Introductionmentioning

confidence: 99%

The Effects of a Personal Oxygen Supplement on Performance, Recovery, and Cognitive Function During and After Exhaustive Exercise

Etheredge

Judge

Bellar³

2014

Journal of Strength and Conditioning Research

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The purpose of this investigation was to examine the effects of a personal oxygen supplement (OS) on performance during exhaustive exercise, respiratory responses during exhaustive exercise, and cognitive function after exhaustive exercise. The participants for this blind placebo-controlled experiment were apparently healthy college-aged adults (n = 20). First, VO2max was assessed (47.6 ± 9.8 ml O2·kg(-1)·min(-1)). Participants then ran 2 trials at 80% of VO2max speed to exhaustion and received either a placebo (compressed air) or personal OS. Psychomotor vigilance testing (PVT) was performed before and after each trial. Performance between treatments was evaluated through repeated measures analysis of variance (ANOVA) and was not found to be different (p = 0.335, ηp2 = 0.052), and order (placebo first or personal OS first) was not significant within the model (p = 0.305, ηp2 = 0.058). Mean times were 1,057.6 ± 619.8 seconds for the oxygen trials and 992.5 ± 463.1 seconds for the placebo trials. Repeated measures ANOVAs were used to assess minute ventilation (Ve, L·min(-1)) and VCO2 (L·O2·min(-1)) during exercise and recovery, mean heart rate during recovery, and PVT results. Treatment was nonsignificant (p > 0.05) nor were any interaction effects (treatment × time, p > 0.05) for any variables. The results of this study suggest that a personal OS had no effect on performance and did not affect ventilation even at the time directly surrounding the application. The results of the study also suggest that personal OS do not enhance exercise recovery or cognition during exercise recovery.

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The role of oxygen-increased respirator in humans ascending to high altitude

Cited by 11 publications

References 18 publications

Evaluation of the Visual Analog Score (VAS) to Assess Acute Mountain Sickness (AMS) in a Hypobaric Chamber

Evaluation of the Visual Analog Score (VAS) to Assess Acute Mountain Sickness (AMS) in a Hypobaric Chamber

Study on the Oxygen Enrichment Effect of Individual Oxygen-Supply Device in a Tunnel of Plateau Mine

The Effects of a Personal Oxygen Supplement on Performance, Recovery, and Cognitive Function During and After Exhaustive Exercise

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