The role of oxidative stress and inflammatory response in high-fat diet induced peripheral neuropathy

Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model

“…Stereological analyses of fibroblasts were conducted according to previously described principles. Stereological methods are commonly used in studies on the experimental peripheral nerve injury model to provide correct and trustworthy estimates of histomorphological data (12)(13)(14)(15). We performed stereological morphometric analysis of the fibroblast densities obtained from all rat groups.…”

“…Six different areas were counted for each animal. Stereological analyses of fibroblasts were conducted according to the principles described previously (12)(13)(14)(15). A stereological workstation composed of a digital camera (mbf/Bioscience, Qimaging), an automatically controlled specimen stage, a light microscope (Leica, DM400B), and software (mbf Bioscience, Stereo investigator, version 9) was used to count the fibroblasts.…”

Cutaneous expression of calcium/calmodulin-dependent protein kinase II in rats with type 1 and type 2 diabetes

“…Possible reasons for those varieties could be addressed in multifactorial pathogenesis; disease duration, glycaemic control, dyslipidemia and possibly patient age (Day and Ranum, 2005). Ozay et al postulated that oxidative stress and inflammatory response may play an important role in the pathogenesis of highfat diet induced neuropathy described in DM2 animal model that could explain different pain pathway from those in DM1 animals (Ozay et al, 2014). This study, like the previous one from our group, could contribute to elucidation of neural phenotypic differences between different types of diabetes.…”

Effect of 2 different anesthesia methods on stress response in neurosurgical patients with hypertension or normal

“…Neurosurgery trauma, anesthesia, hypoxia, and pain can make the body produce the stress response, [2] so that the body produces severe metabolic and homeostasis disorders and immune suppression, leading to massive release of hormones and blood sugar into the blood, causing serious physiological dysfunction, inflammation, and proliferation. [3] However, hypertension is a special disease, especially in patients with long-term high blood pressure in which the body functions are degraded corresponding pathological changes, in particular dyfunctions of the cardiovascular system. [4,5] Therefore, hypertension patients are more likely to have strong stress response caused by injury of surgery operation compared with non-hypertension patients.…”