The role of oxidative stress in antipsychotics induced ovarian toxicity

Elmorsy, Ekramy; Al‐Ghafari, Ayat B.; Aggour, Amal Misbah; Khan, Raheela; Amer, Saad

doi:10.1016/j.tiv.2017.07.008

Cited by 25 publications

(16 citation statements)

References 40 publications

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“…Conflicting results have been obtained in a variety of studies on the antioxidant effect of treatments based on typical and atypical antipsychotics and lithium, and how they regulate oxidative stress in preclinical studies (18,19,(35)(36)(37)(38)(39). In our study, an increase in oxidative stress levels and a decrease in antioxidant response were noted in the two groups at 6 months, regardless of the medication administered.…”

Section: Discussioncontrasting

confidence: 62%

Association between medication adherence and oxidative stress in patients with first-episode mania

González‐Pinto¹,

Fernández²

2019

Preprint

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Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to medication, severity of symptoms and oxidative stress in a sample of patients with a first episode of mania. A longitudinal, 6-month study was performed in 60 patients, who were classified as adherent and non-adherent to medication (mainly antipsychotics). Blood levels of oxidative stress parameters and expression of the antioxidant nuclear transcription factor NRF2 in mononuclear cells of peripheral blood were assessed at baseline and at the end of follow-up. In addition, clinical symptoms and functioning were evaluated. Linear multivariate regression was used to determine the relationship between adherence, oxidative stress, and clinical symptoms. Finally, 44 patients completed follow-up. The results of this study showed that at 6-month follow-up, adherence was significantly associated with better functioning and reduced clinical symptoms. Additionally, more severe symptoms were associated with increased levels of oxidative stress and antioxidant parameters. At study completion, non-adherents exhibited greater levels of antioxidants than adherent patients. In conclusion, poor adherence to medication is associated with a poorer prognosis in the medium term and causes increased antioxidant response.

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Section: Discussioncontrasting

confidence: 62%

Association between medication adherence and oxidative stress in patients with first-episode mania

González‐Pinto¹,

Fernández²

2019

Preprint

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“…In nonreproductive cells (liver and kidney) ROS was shown to augment ROS production and lipid peroxidation, mitochondrial membrane potential collapse, GSH depletion and lysosomal membrane injury. In the only study investigating the effects of antipsychotics on reproductive cells was on ovarian cells suggested without a particular touch on RIS, antipsychotics might induce oxidative stress on reproductive cells with similar mechanisms on nonreproductive cells (Eftekhari et al, 2016;Elmorsy, Al-Ghafari, Aggour, Khan, & Amer, 2017).…”

Section: Discussionmentioning

confidence: 99%

Risperidone induced reproductive toxicity in male rats targeting leydig cells and hypothalamic–pituitary–gonadal axis by inducing oxidative stress

et al. 2020

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Infertility affects 15% of couples worldwide as the disease of the reproductive system and 30%-50% of infertile cases are related to male-dependent factors (Ghuman & Ramalingam, 2017; 'Mother or nothing: the agony of infertility', 2010). Recent studies have shown that sperm quality is decreasing all over the world. The exact cause of this situation has not been fully understood; however, chronic exposures to chemicals especially drugs take an important place (Gabrielsen & Tanrikut, 2016). The complex aetiology underlying male-factor infertility makes it harder to understand at what level drug exposures are responsible for it. Additionally, the number of chronic disease cases, such as migraine, depression, and epilepsy, is increasing year by year, pointing out the fact that long-term drug exposures become frequently because of the need of treating these diseases at younger ages (Kristensen, 2018). Schizophrenia is a serious psychiatric disorder, results in longterm antipsychotic treatment. Today, atypical antipsychotics are the

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“…Accumulating evidence has indicated that poor oocyte quality is a common and unmanageable problem for women with advanced maternal age, which leads to the unsuccessful reproductive outcome [[7], [8], [9]]. Age-related quality decrease in the ovary reserve occurs as a result of two processes: increased oxidative damage in oocytes caused by excessive reactive oxygen species (ROS) [[10], [11], [12]] and compromised antioxidant defense systems. ROS is produced primarily in the mitochondria as a byproduct of metabolism.…”

Section: Introductionmentioning

confidence: 99%

Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes

Zhang

Chen

et al. 2020

Redox Biology

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Age-related decline in female fertility is a common feature that occurs in the fourth decade of women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies to prevent the deterioration of maternal aged oocytes and relevant mechanisms are still underexplored. Here, we find that the reduced abundance of melatonin in the follicular fluid highly correlates with the advanced maternal age-related aneuploidy. Of note, we show that exposure of oocytes from aged mice both in vitro and in vivo to exogenous melatonin not only eliminates the accumulated reactive oxygen species-induced DNA damage and apoptosis, but also suppresses the occurrence of aneuploidy caused by spindle/chromosome defect that is frequently observed in aged oocytes. Importantly, we reveal that melatonin supplementation reverses the defective phenotypes in aged oocytes through a Sirt1/Sod2-dependent mechanism. Inhibition of Sirt1 activity abolishes the melatonin-mediated improvement of aged oocyte quality. Together our findings provide evidence that supplementation of melatonin is a feasible way to protect oocytes from advanced maternal age-related meiotic defects and aneuploidy, demonstrating the potential for improving the quality of oocytes from aged women and the efficiency of assisted reproductive technology.

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The role of oxidative stress in antipsychotics induced ovarian toxicity

Cited by 25 publications

References 40 publications

Association between medication adherence and oxidative stress in patients with first-episode mania

Association between medication adherence and oxidative stress in patients with first-episode mania

Risperidone induced reproductive toxicity in male rats targeting leydig cells and hypothalamic–pituitary–gonadal axis by inducing oxidative stress

Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes

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