The role of oxidative stress in mechanisms of metal-induced carcinogenesis

Galaris, Dimitrios; Evangelou, Angelos

doi:10.1016/s1040-8428(01)00212-8

Cited by 161 publications

(99 citation statements)

References 84 publications

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“…Various environmental stresses lead to excessive production of ROS, which can cause progressive oxidative damage and ultimately cell death (Galaris and Evangelou, 2002;Shi et al, 2004). In the present study, significant variations of SOD, CAT activities and MDA content were recorded in the digestive glands of oysters from each sampling site.…”

Section: Discussionmentioning

confidence: 63%

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Tian

Song

et al. 2016

Marine Pollution Bulletin

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a b s t r a c t a r t i c l e i n f oArticle history: Received 9 January 2016 Received in revised form 26 July 2016 Accepted 29 July 2016 Available online xxxx An integrative biomarker approach was employed to evaluate the environmental quality of the north coast of Shandong Peninsula along the southern Bohai Sea of China, where pollution is an imminent threat due to rapid urbanization and industrialization. A battery of biomarkers and the metal bioaccumulation in tissues of native oyster Crassostrea gigas were measured under field conditions. Integrative biomarker index (IBR) and metal body burden were calculated to differentiate the pollution status of seven sampling sites. According to our results, Xinzhuang (XZ) site was the most severely contaminated, with the highest IBR value of 3.58, while the lowest IBR value (0.04) was obtained at Penglai (PL). Such an integrated biomarker approach was proved as a useful method for environmental quality assessment in the study area.

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Section: Discussionmentioning

confidence: 63%

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Tian

Song

et al. 2016

Marine Pollution Bulletin

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“…Metal ions induce reactive oxygen species (ROS), and thus, lead to the generation of free radicals [14,15]. ROS accumulation can affect epigenetic factors [16].…”

Section: Discussionmentioning

confidence: 99%

Promoter Hypermethylation Profile of Tumour Suppressor Genes in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Asokan¹,

Jeelani²,

Gnanasundaram³

2014

JCDR

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Purpose of the Study: The present study was conducted to evaluate epigenetic alteration of five tumour suppressor genes in the oral precancer and cancer patients. Materials and Methods:The study was carried out in three groups namely control group of five people (normal healthy individuals), 10 oral leukoplakia patients and 10 oral squamous cell carcinoma patients. Incisional biopsy was done and part of the tissue sent for histological examination and part of tissue sent for hypermethylation study of p16, p15, hMLH, MGMT, E-cadherin tumour suppressor genes. Methylation specific polymerase chain reaction was carried out for detecting methylation in promoter regions of tumour suppressor genes. The resultant PCR products were run in a 2.5% agarose gel and the promoter hypermethylation status of the five tumour suppressor genes were analysed. Results:In oral Leukoplakia patients, 60% of methylation in the case of p16 gene, 30% of methylation in the case of MGMT gene and 60% of methylation in the case of E-cadherin gene. In oral Squamous cell carcinoma patients, 60% of methylation in the case of p16 gene, 40% of methylation in the case of MGMT, 60% of methylation in the case of E-cadherin gene, 20% in case of p15,10% in case of hMLH gene. Conclusion:Our results suggest that epigenetic mechanisms of inactivation of tumour suppressor genes, such as aberrant methylation of p16 and E-cadherin genes occur early in head and neck tumourigenesis and might play a role in the progression of these lesions.

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“…The first is the direct or indirect modulation of cellular DNA repair [Hengstler et al, 2003]. The second pathway is based on the modulation of transcriptional factors such as NF-jB and AP-1 [Galaris and Evangelou, 2002]. Al, which also was correlated with DNA damage, is capable of inducing CA, micronuclei, In each cell, the first number is the correlation coefficient (r) and the second number is the P-value.…”

Section: Discussionmentioning

confidence: 99%

“…Zn is considered to be a metal that prevents the induction of oxidative stress [Galaris and Evangelou, 2002]. However, excess Zn and Zn deficiency can lead to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Assessment of occupational exposure to welding fumes by inductively coupled plasma‐mass spectroscopy and by the alkaline Comet assay

Botta¹,

Iarmarcovai²,

Chaspoul³

et al. 2006

Environ and Mol Mutagen

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Welding fumes are classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer. In the current study, blood and urine concentrations of aluminum (Al), cadmium (Cd), cobalt (Co), chromium (Cr), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) were monitored by inductively coupled plasma-mass spectrometry (ICP-MS) in 30 welders and in 22 controls. In addition, DNA damage was examined in the lymphocytes of these subjects by the alkaline Comet assay. Two biological samples were taken from the welders at the beginning (BW) and at the end (EW) of a work week. In controls, collection of samples was limited to BW. Blood concentrations of Cd, Co, Cr, Ni, and Pb were higher in the welders than in the control group while higher concentrations of Al, Cd, Co, Cr, Ni, and Pb were detected in welder urines.There was no significant difference in the metal concentrations for the BW and EW welder samples. Increased levels of DNA damage were found in lymphocytes from welders as compared to the controls, and 20/30 welders had higher levels of DNA lesions in the EW than in the BW samples. Age had a significant effect on DNA damage in the control group. Spearman's rank correlation analysis indicated that there were positive correlations between blood concentrations of Al, Co, Ni, and Pb and the levels of DNA damage. A negative correlation was found between DNA damage and Mn in blood, while there was a positive correlation between urinary Mn concentration and DNA damage. These data indicate that occupational exposure to welding fumes increases DNA damage in lymphocytes. Environ. Mol. Mutagen. 47:284-295, 2006. V V C 2006 Wiley-Liss, Inc.

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The role of oxidative stress in mechanisms of metal-induced carcinogenesis

Cited by 161 publications

References 84 publications

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Promoter Hypermethylation Profile of Tumour Suppressor Genes in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Assessment of occupational exposure to welding fumes by inductively coupled plasma‐mass spectroscopy and by the alkaline Comet assay

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