The role of oxidative stress in bronchoconstriction due to occupational sulfur dioxide exposure

Elevated plasma glutathione peroxidase concentration in acute severe asthma: Comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde

“…The MDA levels were not elevated when compared with other studies; however, there appears to be significant variability in normal levels between groups, which makes comparisons difficult [27][28][29]. Measurement of the MDA-TBA (malondialdehyde-thiobarbituric acid) adduct is the most widely used method for evaluating lipid peroxidation and was chosen as the biomarker for oxidative stress in this study due to the relative stability.…”

The Association between Adult Asthma and Superoxide Dismutase and Catalase Gene Activity

“…Superoxide anion is catalysed by SOD activity to transform H 2 O 2 to harmless H 2 O through CAT [5,6]. SOD activity is decreased when inflammatory cells are induced to produce enhanced levels of oxygen radicals [4,5].…”

“…Excessive oxidative stress results in the inactivation of SOD or deficient cellular defence [8,33]. Another possibility involves the utilisation of antioxidants for protection of cellular structures from damage by extreme free radicals and oxidative stress, thereby decreasing the level of antioxidant enzyme activity [5,34]. Smith et al [35] suggested reducing SOD activity by inflammatory mediators such as transforming growth factor (TGF)-β. TGF-β can inhibit the expression of antioxidant enzyme genes such as Mn-SOD and copper-zinc SOD in cultured rat hepatocytes [36] and can reduce Mn-SOD in cultured human skin fibroblasts [37].…”

“…Superoxide anion is catalysed by SOD activity to transform H 2 O 2 and then forms harmless H 2 O through CAT or glutathione peroxidases [5,6]. SOD include intracellular copper-zinc SOD, mitochondrial manganese SOD (Mn-SOD) and extracellular SOD [6].…”

Oxidativer Stress und Möglichkeiten seiner Messung aus umweltmedizinischer Sicht

“…Untersuchungen bei Arbeitsplatz-exponierten Personen zeigen nicht selten Assoziationen zwischen Schadstoffexposition und oxidativem Stress [28,29,30,31]. Deswegen ist die Frage von Interesse, ob auch Umwelteinflüsse das Risiko für oxidative Schädigungen erhöhen können [7,32,33,34,35] und ob ein Schädigungsrisiko diagnostisch erfassbar ist [7,32,36] Nach Referenzen [127,128,129] ten der Ersteren charakterisiert ist und in dem im menschlichen Körper anfallende reaktive Spezies nicht ausreichend durch Antioxidantien neutralisiert werden kön-nen.…”