The role of oxidative stress in the biology of melanoma: A systematic review

Cannavò, Serafinella Patrizia; Tonacci, Alessandro; Bertino, Lucrezia; Casciaro, Marco; Borgia, Francesco; Gangemi, Sebastiano

doi:10.1016/j.prp.2018.11.020

Cited by 50 publications

(33 citation statements)

References 48 publications

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“…However, as already mentioned, maintaining the redox equilibrium is a multifactorial process of which GSTs are only a part, whose importance may vary depending on the interplay between all factors. It is well known that the GSTM1 null and the GSTT1 null genotypes are frequent in the general population, but with significant worldwide variability [58][59][60], and their role and "relative weight" as risk factors for several dermatologic conditions may range from irrelevant to highly significant, depending on the population studied [10,11,[58][59][60][61][62][63][64][65]. Similar considerations may be applied to GSTP1 polymorphisms [66,67].…”

Section: Discussionmentioning

confidence: 99%

“…Over time, accumulation of ROS eventually exceeds the defense capacity of the antioxidant system (AOS). This condition, defined oxidative stress (OS), plays a role in the pathogenesis of AD, as well as in other cutaneous and non-cutaneous diseases [10][11][12]. Atopic dermatitis is characterized by infiltration of inflammatory cells, such as lymphocytes, macrophages, eosinophils, and mast cells.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress and Atopic Dermatitis

et al. 2020

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Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Atopic Dermatitis

et al. 2020

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“…Though surgery remains the main and definitive treatment for early-stage melanoma but it's rarely curative for the advanced stages of melanomas [6]. Importantly, oxidative stress has been reported to be associated with the transformation and progression of melanoma [7] and the induction of oxidative stress could inhibit distant metastasis in circulating melanoma cells in vivo [8]. Additionally, long noncoding RNAs (lncR-NAs) have been confirmed to exert a critical role in the regulation of tumorigenesis and the progression of melanoma [9].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA GAS5 accelerates oxidative stress in melanoma cells by rescuing EZH2-mediated CDKN1C downregulation

Yan

et al. 2020

Cancer Cell Int

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Background: The significance of long non-coding RNAs (lncRNAs) in mediating oxidative stress of cancers has been implicated recently. This study proposed a potential therapeutic target lncRNA growth arrest-specific transcript 5 (GAS5) for melanoma, due to its crucial role in oxidative stress and apoptosis of melanoma cells by regulating the enhancer of zeste homolog 2 (EZH2)-mediated CDKN1C expression. Methods: The lncRNA GAS5 expression pattern was examined in melanoma tissues and cells. The correlation of lncRNA GAS5, EZH2, and CDKN1C with survival rate of melanoma patients was analyzed. In melanoma cell lines, lncRNA GAS5 expression was overexpressed or knocked down to clarify its effects on cell viability, apoptosis, and oxidative stress. The interaction between lncRNA GAS5 and EZH2 was examined by RIP and RNA pull-down assays followed by verification of the target relationship between EZH2 and CDKN1C. Results: High expression of EZH2 and poor expression of lncRNA GAS5 and CDKN1C was observed in melanoma tissues and found to be correlated with the reduction in survival expectancy of melanoma patients. Overexpression of lncRNA GAS5 or CDKN1C or EZH2 knockdown could inhibit cell viability but enhance melanoma cell apoptosis and oxidative stress. Importantly, lncRNA GAS5 attenuated EZH2 expression by recruiting E2F4 to the EZH2 promoter region and knockdown of EZH2 upregulated CDKN1C expression by inhibiting the H3K27me3. Conclusion: The evidence provided by our study highlighted the involvement of lncRNA GAS5 in the translational suppression of EZH2 as well as the upregulation of CDKN1C, resulting in the promotion of melanoma cell apoptosis and oxidative stress.

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“…This indicates that urinary DHICA has great clinical value in the progression of melanoma. Dopachrome tautomerase (DCT), the melanogenic enzyme is known for its overexpression in human melanoma cells that are resistant to both chemotherapy and radiation therapy [12,13]. According to Pak and Ben-David [14] the resistance is mediated through the accumulation of DHICA, which activates phosphor-extracellular signal-related kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway.…”

Section: Discussionmentioning

confidence: 99%

Specific Urinary Metabolites in Malignant Melanoma

et al. 2019

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Background and objectives: Melanin, which has a confirmed role in melanoma cell behaviour, is formed in the process of melanogenesis and is synthesized from tryptophan, L-tyrosine and their metabolites. All these metabolites are easily detectable by chromatography in urine. Materials and Methods: Urine samples of 133 individuals (82 malignant melanoma patients and 51 healthy controls) were analysed by reversed-phase high-performance liquid chromatography (RP-HPLC). The diagnosis of malignant melanoma was confirmed histologically. Results: Chromatograms of melanoma patients showed increased levels of 5,6-dihydroxyindole-2-carboxylic acid, vanilmandelic acid, homovanilic acid, tryptophan, 5-hydroxyindole-3-acetic acid, and indoxyl sulphate compared to healthy controls. Concentration of indoxyl sulphate, homovanilic acid and tryptophan were significantly increased even in the low clinical stage 0 of the disease (indoxyl sulphate, homovanilic acid and tryptophan in patients with clinical stage 0 vs. controls expressed as medium/ interquartile range in µmol/mmol creatinine: 28.37/15.30 vs. 5.00/6.91; 47.97/33.08 vs. 7.33/21.25; and 16.38/15.98 vs. 3.46/6.22, respectively). Conclusions: HPLC detection of metabolites of L-tyrosine and tryptophan in the urine of melanoma patients may play a significant role in diagnostics as well as a therapeutic strategy of melanoma cancer.

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The role of oxidative stress in the biology of melanoma: A systematic review

Cited by 50 publications

References 48 publications

Oxidative Stress and Atopic Dermatitis

Oxidative Stress and Atopic Dermatitis

Long non-coding RNA GAS5 accelerates oxidative stress in melanoma cells by rescuing EZH2-mediated CDKN1C downregulation

Specific Urinary Metabolites in Malignant Melanoma

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