The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner

Vitale, Salvatore Giovanni; Capriglione, Stella; Peterlunger, Isabel; Rosa, Valentina Lucia La; Vitagliano, Amerigo; Noventa, Marco; Valenti, Gaetano; Sapia, Fabrizio; Angioli, Roberto; Lopez, Salvatore; Sarpietro, Giuseppe; Rossetti, Diego; Zito, Gabriella

doi:10.1155/2018/7924021

Cited by 101 publications

(65 citation statements)

References 142 publications

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“…A frequent error is the hysteroscopic finding of the normal endometrium, rather than the hyperplastic endometrium, which is then diagnosed histologically [26,29,30]. These findings are likely associated with an intrinsic bias of the operator, which is considered a reasonable functional condition that determines the presence of homogeneous endometrial thickening with a regular surface.…”

Section: Discussionmentioning

confidence: 99%

Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination

et al. 2019

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The goal of this paper is to assess the concordance between the clinical diagnosis of Endometrial Hyperplasia (EH), suspected by senior gynecologists throughout outpatient office hysteroscopy, and the results from histopathological examination, in order to evaluate hysteroscopic accuracy for EH. A prospective cohort study was done at a Tertiary University Hospital. From January to December 2018, we enrolled women with the following criteria: abnormal uterine bleeding in post-menopause and endometrial thickening in pre-or post-menopause. Patients underwent office hysteroscopy with a 5 mm continuous-flow hysteroscope, and endometrial biopsies were taken using miniaturized instruments. Senior operators had to foresee histopathological diagnosis using a questionnaire. Histopathological examination was conducted to confirm the diagnosis. This study was approved by the local ethical and registered in the ClinicalTrials.gov registry (ID no. NCT03917147). In 424 cases, 283 clinical diagnoses of EH were determined by senior surgeons. A histopathological diagnosis was then confirmed in 165 cases (58.3%; p = 0.0001). Furthermore, 14 endometrial carcinoma and atypical hyperplasia were found. The sensitivity, positive predictive value, and negative predictive values for EH were, respectively, 90.4, 58.4, and 86.6%. Subdivided by clinical indication, the sensitivity was higher in patients with post-menopause endometrial thickening. The diagnostic accuracy of office hysteroscopy in the diagnosis and prediction of endometrial hyperplasia was high. Senior operators could foresee EHs in more than half the cases.

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Section: Discussionmentioning

confidence: 99%

Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination

et al. 2019

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“…It is marked by an inflammatory state associated with inflammatory mediators. Recently, it has been shown that epigenetic mechanisms control biological aberrations in endometriosis, and the heterogeneity of endometriosis suggests that it is a complex disease and a single model is not sufficient for explaining its pathogenesis [62][63][64][65]. Environmental toxins may be important issues of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Mono-n-Butyl Phthalate in Women with Endometriosis and Its Association with the Biological Effects on Human Granulosa Cells

Chou

Chen

et al. 2020

IJMS

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To study the association between urinary phthalate metabolite levels, endometriosis, and their effects on human granulosa cells, we recruited patients who underwent laparoscopy to confirm endometriosis (n = 123) and control patients (n = 78). Liquid chromatography–tandem mass spectrometry was used to measure the following five urinary phthalate metabolites: mono-n-butyl phthalate (MnBP), mono(2-ethylhexyl) phthalate, monobenzyl phthalate, mono(2-ethyl-5-oxo-hexyl) phthalate, and mono(2-ethyl-5-hydroxyhexyl) phthalate. Urinary MnBP levels were higher in patients with endometriosis than in controls after multivariable logistic regression including the number of deliveries, body mass index, and use of medicine as covariables. MnBP correlates with other phthalate metabolites. Previous studies found that endometriosis was a detrimental condition for granulosa cells. In our study, we observed whether MnBP affected granulosa cells. MnBP treatment altered the gene expression of BIRC5, BUB1B, CDC20, cyclin B1, IL-1β, TNF-α, inhibin-B, StAR, and P450ssc and attenuated the ratio of the mitochondrial membrane potential in human granulosa cells. Moreover, MnBP decreased the expression of the anti-Mullerian hormone. These findings suggest that MnBP concentration is associated with endometriosis and may affect the health and steroidogenesis of human granulosa cells.

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“…We suspect that this is another reason for HSYA having potential in PCOS therapy. Moreover, oxidative stress is associated with endometriosis (Laganà et al., ; Murri et al., ; Vitale et al., ). Recent studies have drawn attention to the role of oxidative stress, which may be implicated in the pathophysiology of endometriosis causing a general inflammatory response in the peritoneal cavity, since ROS are intermediates produced by normal oxygen metabolism and are inflammatory mediators known to modulate cell proliferation and have deleterious effects (Scutiero et al., ).…”

Section: Discussionmentioning

confidence: 99%

Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice

Luo

Huang

Yang

et al. 2020

Experimental Physiology

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Polycystic ovary syndrome (PCOS) is the most common endocrine disease resulting in female infertility. Hydroxysafflor yellow A (HSYA) and ginsenoside Rb1 have been shown to have antioxidant properties, but little is known about their impact in PCOS. Here dehydroepiandrosterone was used to induce PCOS in a mouse model that was characterized by an irregular oestrous cycle, cystic follicles and an elevated serum testosterone level. Supplementation of HSYA restored the oestrous cycle of PCOS mice, reduced follicular cysts in PCOS mouse ovaries and brought about a decline in serum testosterone level, while ginsenoside Rb1 did not ameliorate the above symptoms of PCOS mice. After HSYA treatment, there was elevation of serum oestradiol, progesterone, luteinizing hormone and anti-Müllerian hormone levels and a reduction of follicle-stimulating hormone level, but ginsenoside Rb1 only rescued the levels of follicle-stimulating hormone and anti-Müllerian hormone. Further analysis evidenced that HSYA reversed the expression of steroid hormone secretion-related genes Star, Hsd3b1, Cyp11a1 and Cyp19a1. In PCOS mice HSYA weakened the elevation of ovarian malondialdehyde, which is regarded as a biomarker for oxidative stress. Moreover, HSYA improved reduced glutathione content accompanied by a simultaneous increase in reduced to oxidized glutathione ratio, and enhanced the activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase. Collectively, HSYA exerted beneficial effects on PCOS mice by restoring hormone secretion and alleviating oxidative stress.

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The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner

Cited by 101 publications

References 142 publications

Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination

Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination

Exposure to Mono-n-Butyl Phthalate in Women with Endometriosis and Its Association with the Biological Effects on Human Granulosa Cells

Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice

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