The role of oxidative stress in anxiety disorder: cause or consequence?

Fedoce, Alessandra das Graças; Ferreira, Fernando; Bota, Robert G.; Bonet-Costa, Vicent; Sun, Patrick Y.; Davies, Kelvin J.A.

doi:10.1080/10715762.2018.1475733

Cited by 147 publications

(111 citation statements)

References 150 publications

(136 reference statements)

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“…From the evidence reviewed above, indicating a strong association between oxidative stress markers and anxiety-related behavior, the key question that arises is whether oxidative stress regulatory systems -particularly those engrained in the mitochondria-can modulate anxiety [72], and whether oxidative stress is a cause or a consequence of anxiety [73].…”

Section: Studies Targeting Genes Involved In Oxidative Stressmentioning

confidence: 99%

Anxiety and Brain Mitochondria: A Bidirectional Crosstalk

Filiou

Sandi

2019

Trends in Neurosciences

107

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Accumulating data highlight the contribution of brain mitochondria and bioenergetics to psychiatric disorders and stress-related pathologies. Although anxiety has not received much attention in this booming literature, a bidirectional interplay between anxiety and brain mitochondria and metabolism has recently started to emerge. Substantial observations indicate alterations in mitochondria and metabolism in highly anxious individuals and, conversely, anxiety symptoms in humans suffering from mitochondrial disorders. Genetic and pharmacological efforts have made substantial progress at advancing the causal involvement of specific mitochondrial and metabolic factors in anxiety. In this review, we discuss this converging evidence and highlight the relevance to develop a research focus on targeting mitochondria as a promising approach to alleviate anxiety.

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Section: Studies Targeting Genes Involved In Oxidative Stressmentioning

confidence: 99%

Anxiety and Brain Mitochondria: A Bidirectional Crosstalk

Filiou

Sandi

2019

Trends in Neurosciences

107

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“…Oxidative stress is another marker extensively investigated in psychiatric disorders, consisting of different mechanisms regulating the balance between reactive oxygen species (ROS) and antioxidant defenses [243]. Altered oxidative mechanisms may be responsible for the pathophysiology of psychiatric disorders as well and explain the overlap between ADs and other inflammatory-based diseases.…”

Section: Inflammation and Immune Systemmentioning

confidence: 99%

Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

et al. 2020

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Anxiety disorders are prevalent and highly disabling mental disorders. In recent years, intensive efforts focused on the search for potential neuroimaging, genetic, and peripheral biomarkers in order to better understand the pathophysiology of these disorders, support their diagnosis, and characterize the treatment response. Of note, peripheral blood biomarkers, as surrogates for the central nervous system, represent a promising instrument to characterize psychiatric disorders, although their role has not been extensively applied to clinical practice. In this report, the state of the art on peripheral biomarkers of DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th edition) Anxiety Disorders is presented, in order to examine their role in the pathogenesis of these conditions and their potential application for diagnosis and treatment. Available data on the cerebrospinal fluid and blood-based biomarkers related to neurotransmitters, neuropeptides, the hypothalamic–pituitary–adrenal axis, neurotrophic factors, and the inflammation and immune system are reviewed. Despite the wide scientific literature and the promising results in the field, only a few of the proposed peripheral biomarkers have been defined as a specific diagnostic instrument or have been identified as a guide in the treatment response to DSM-5 Anxiety Disorders. Therefore, further investigations are needed to provide new biological insights into the pathogenesis of anxiety disorders, to help in their diagnosis, and to tailor a treatment.

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“…It has been suggested that oxidative stress (OS) plays a role in TMD and the experience of pain related to TMD 19,20 . It has also been proposed that increased OS may be associated with the pathogenesis of depression 21 and anxiety disorders 22 . Although OS has been implicated in the pathophysiology of many diseases due to the observed associations between OS and clinical symptoms 23 , whether OS is the cause or consequence of a disease (or perhaps both) remains elusive.…”

Section: Effect Of Occlusal Splint On Oxidative Stress Markers and Psmentioning

confidence: 99%

Effect of occlusal splint on oxidative stress markers and psychological aspects of chronic temporomandibular pain: a randomized controlled trial

Alajbeg

Vrbanović

Lapić

et al. 2020

Sci Rep

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have their natural teeth and maintain good oral hygiene. Participants were not suitable if they were experiencing (1) inflammatory joint disease, (2) orofacial pain unrelated to TMD, (3) chronic systemic diseases (i.e. diabetes, cardiovascular diseases, malignancies, and autoimmune diseases), (4) causes of headache, unrelated to TMD, listed in the International Classification of Headache Disorders (ICDH II), (5) periodontitis, oral lesions and gum swelling. Individuals who had already been under treatment for TMD were excluded. Finally, participants who use supplements and medication known to affect the oxidative status, and smoke were not able to take part in the study. Study design. Allocation. To reduce the waiting time and potential withdrawal until a sufficient number of participants are involved, we have chosen a randomization procedure based on our experience of enrolling 6-8 participants in 2 months. The patients were assigned into two treatment groups utilizing random block randomization with a block size of 8 and 6. Randomization was computer-generated, and participants were randomly assigned to two treatment arms, SS or PS. The allocation was prepared by the study's statistician prior to enrollment of the participants. Blinding. Participants were unaware of the differences of each intervention. The principal investigator (IZA), who conducted the baseline evaluations, was the only person aware of the participants' treatment conditions. All follow-up assessments were performed by the investigator (EV), blinded to the group allocation. Observer training. Ten randomly selected subjects, different from the ones included in the investigation, underwent repeated clinical examinations by two experienced examiners to assess signs and symptoms of TMD (according to DC/TMD). No significant differences were recognized between the first and the second measurements (p = 0.87-0.89, paired t-test). The weighted kappa statistics showed adequate agreement between the observers (κ = 0.86-0.88).

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The role of oxidative stress in anxiety disorder: cause or consequence?

Cited by 147 publications

References 150 publications

Anxiety and Brain Mitochondria: A Bidirectional Crosstalk

Anxiety and Brain Mitochondria: A Bidirectional Crosstalk

Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

Effect of occlusal splint on oxidative stress markers and psychological aspects of chronic temporomandibular pain: a randomized controlled trial

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