The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimer’s Disease and Vascular Dementia

Abstract

Oxidative stress (OS) has been demonstrated to be involved in the pathogenesis of the two major types of dementia: Alzheimer's disease (AD) and vascular dementia (VaD). Evidence of OS and OS-related damage in AD is largely reported in the literature. Moreover, OS is not only linked to VaD, but also to all its risk factors. Several researches have been conducted in order to investigate whether antioxidant therapy exerts a role in the prevention and treatment of AD and VaD. Another research field is that pertaining to the heat shock proteins (Hsps), that has provided promising findings. However, the role of OS antioxidant defence system and more generally stress responses is very complex. Hence, research on this topic should be improved in order to reach further knowledge and discover new therapeutic strategies to face a disorder with such a high burden which is dementia.

Assessment of Possible Association Between Antioxidant Levels and Apoe Gene Polymorphism in Demented Saudi Population

“…In general, results of present study consist with the hypothesis that suggest the role of oxidative stress in the physiopathology of dementia as it is involved in the crucial events leading to the neural death (Cervellati et al, 2014;Luca et al, 2015). However, other studies have shown no clear association between oxidative stress and dementia (Pulido et al, 2005;Zafrilla et al, 2006;Sekler et al, 2008;Chang et al, 2014).…”

Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study

“…Several in vivo and in vitro experiments have suggested that mushrooms have beneficial effects on cognitive function. Some animal experiments have revealed that mushrooms can protect cells from oxidative damage and inflammation, both of which have been implicated in the pathogenesis of dementia . Mushrooms have also been shown to have hypolipidemic and antiatherogenic effects, playing an indirect role in dementia prevention.…”

Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan

“…Increasing evidence supports the notion that the cognitive function is impaired by excessive oxidative stress (19,20). The K residents who reduced the frequency of Japanese pickle consumption or rarely ate Japanese pickles showed higher MMSE and FAB scores and lower Mn and V contents in the scalp hair than those who frequently consumed Japanese pickles.…”