The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review

Hashimoto, Kazuhiko; Akagi, Masao

doi:10.1177/0300060520931609

Cited by 26 publications

(22 citation statements)

References 92 publications

(117 reference statements)

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“…In addition to iron overload, a large amount of unsaturated lipids also exerts a ferroptotic effect. High lipid levels translate to high ROS and other radical levels, which activate NF-κB signaling pathways and induce inflammation [ 106 ]. Collectively, these results suggest that obese people are more likely to experience collar destruction resulting from fatty oxide exposure and ferroptosis.…”

Section: Discussion and Future Prospectsmentioning

confidence: 99%

“…Obesity is no longer the sole burden of obese patients but has gradually become the burden of the whole society [ 107 ]. Fatty acids and cholesterol are could be stressful environments, and the cytokines produced by fat cells exert numerous inflammatory effects that often exacerbate other underlying conditions [ 106 ]. In summary, previous studies have investigated the potential relationship between lipid or cholesterol metabolism and bone metabolism at the cellular level.…”

Section: Discussion and Future Prospectsmentioning

confidence: 99%

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Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages

Wang

et al. 2022

Lipids Health Dis

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Recent advances in society have resulted in the emergence of both hyperlipidemia and obesity as life-threatening conditions in people with implications for various types of diseases, such as cardiovascular diseases and cancer. This is further complicated by a global rise in the aging population, especially menopausal women, who mostly suffer from overweight and bone loss simultaneously. Interestingly, clinical observations in these women suggest that osteoarthritis may be linked to a higher body mass index (BMI), which has led many to believe that there may be some degree of bone dysfunction associated with conditions such as obesity. It is also common practice in many outpatient settings to encourage patients to control their BMI and lose weight in an attempt to mitigate mechanical stress and thus reduce bone pain and joint dysfunction. Together, studies show that bone is not only a mechanical organ but also a critical component of metabolism, and various endocrine functions, such as calcium metabolism. Numerous studies have demonstrated a relationship between metabolic dysfunction in bone and abnormal lipid metabolism. Previous studies have also regarded obesity as a metabolic disorder. However, the relationship between lipid metabolism and bone metabolism has not been fully elucidated. In this narrative review, the data describing the close relationship between bone and lipid metabolism was summarized and the impact on both the normal physiology and pathophysiology of these tissues was discussed at both the molecular and cellular levels.

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Section: Discussion and Future Prospectsmentioning

confidence: 99%

Section: Discussion and Future Prospectsmentioning

confidence: 99%

Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages

Wang

et al. 2022

Lipids Health Dis

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“…8 OxLDL is involved in the formation of atherosclerotic plaques, and a known regulator of cartilage degeneration via induction of chondrocyte cell death. 13 PLA2G2A, member of the phospholipase A2 family (PLA2), is the membrane-bound form of phospholipase A2, a lipolytic enzyme that catalyses the hydrolysis of membrane phospholipids. 9 Several phospholipase A2 isoforms have been implicated in the pathogenesis of OA via regulation of inflammation.…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid–Binding Protein 4 (FABP4) Is Associated with Cartilage Thickness in End-Stage Knee Osteoarthritis

et al. 2021

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Background There is no single blood biomarker for the staging of knee osteoarthritis (KOA). The purpose of this study was to assess the relationship of obesity, serum biomarkers, the hip-knee-ankle angle (HKAA) with sonographic cartilage thickness. Methods We conducted a cross-sectional study of n = 33 patients undergoing knee arthroplasty. Body mass index (BMI) was recorded, and patients were grouped based on BMI. Serum blood samples were collected, and the following biomarkers were measured using the ELISA technique (subgroup of n = 23): oxidized low-density lipoprotein (oxLDL), soluble receptor for advanced glycation end-products (sRAGE), fatty acid–binding protein 4 (FABP4), membrane-bound phospholipase A2 (PLA2G2A). The HKAA was analyzed on full-length limb standing x-ray images. Cartilage thickness was assessed on ultrasound images. Multivariable regression analysis was performed to account for confounding. Results After adjusting for age, gender, and HKAA, obese patients had thicker medial femoral cartilage (β = 0.165, P = 0.041). Furthermore, lateral cartilage thickness was negatively correlated with FABP4 level after adjusting for of age, gender, BMI, and HKAA (β = −0.006, P = 0.001). Confirming previous studies, after adjustment, FABP4 level was associated with a higher BMI group (β = 42.99, P < 0.001). None of the other markers (oxLDL, PLA2G2A, and sRAGE) was associated with BMI or cartilage thickness. Discussion Our results indicate that BMI has a weak, positive association with cartilage thickness in end-stage KOA patients. FABP4 levels were negatively associated with cartilage thickness. While our study is limited by a small sample size, these results further highlight the role of FABP4 as promising biomarkers of burden of disease in KOA.

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“…Over the last decade, evidence been accumulating that ox-LDL is important in the pathogenesis of osteoarthritis, another common joint disease that often requires surgical treatment [ 44 ]. It was reported that ox-LDL accumulated in chondrocytes in the pathological process of osteoarthritis and that LOX-1-deficient mice were resistant to osteoarthritis induced by instability or age [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Accumulation of LDL/ox-LDL in the necrotic region participates in osteonecrosis of the femoral head: a pathological and in vitro study

Wang

Chen

et al. 2021

Lipids Health Dis

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Background Osteonecrosis of the femoral head (ONFH) is a common but intractable disease that appears to involve lipid metabolic disorders. Although numerous studies have demonstrated that high blood levels of low-density lipoprotein (LDL) are closely associated with ONFH, there is limited evidence to explain the pathological role of LDL. Pathological and in vitro studies were performed to investigate the role of disordered metabolism of LDL and oxidized LDL (ox-LDL) in the femoral head in the pathology of ONFH. Methods Nineteen femoral head specimens from patients with ONFH were obtained for immunohistochemistry analysis. Murine long-bone osteocyte Y4 cells were used to study the effects of LDL/ox-LDL on cell viability, apoptosis, and metabolism process of LDL/ox-LDL in osteocytes in normoxic and hypoxic environments. Results In the pathological specimens, marked accumulation of LDL/ox-LDL was observed in osteocytes/lacunae of necrotic regions compared with healthy regions. In vitro studies showed that ox-LDL, rather than LDL, reduced the viability and enhanced apoptosis of osteocytes. Pathological sections indicated that the accumulation of ox-LDL was significantly associated with impaired blood supply. Exposure to a hypoxic environment appeared to be a key factor leading to LDL/ox-LDL accumulation by enhancing internalisation and oxidation of LDL in osteocytes. Conclusions The accumulation of LDL/ox-LDL in the necrotic region may contribute to the pathology of ONFH. These findings could provide new insights into the prevention and treatment of ONFH.

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The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review

Cited by 26 publications

References 92 publications

Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages

Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages

Fatty Acid–Binding Protein 4 (FABP4) Is Associated with Cartilage Thickness in End-Stage Knee Osteoarthritis

Accumulation of LDL/ox-LDL in the necrotic region participates in osteonecrosis of the femoral head: a pathological and in vitro study

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