The Role of Oxidants in Percutaneous Coronary Intervention-Induced Endothelial Dysfunction: Can We Harness Redox Signaling to Improve Clinical Outcomes?

Wolhuter, Kathryn; Kong, Stephanie Mei Yung; Stanley, Christopher P.; Kovacic, Jason

doi:10.1089/ars.2022.0204

Cited by 2 publications

(2 citation statements)

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“…The proposed increase in eNOS activity in healthy adults ( 42) is one likely mechanism by which CFs and especially (-)-epicatechin improve vascular function, blood pressure (15,23) and endothelial integrity (43) . Overall dietary interventions have been shown to reestablish disturbed redox signaling in the vasculature (44). As already demonstrated in the COSMOS trial (45) a 27% lowering in cardiovascular deaths can be achieved through CF intake, at the same daily amount as given in the current study, in elderly individuals free from CVD after a 3.6-year follow-up.…”

Section: Effectiveness Of Cfs To Improve Vascular Function In Healthy...supporting

confidence: 69%

Cocoa flavanols improve peakVO₂and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Groene

Duse

Kramser

et al. 2023

Preprint

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Background: Loss of functional capacity and redox signaling is one of the hallmarks in cardiovascular aging. Cocoa flavanols (CF) exert favorable effects on endothelial function, blood pressure, and inflammation. These cardiovascular health markers worsen with increasing age and limit functional exercise capacity. Aim: To investigate the effect of CF on cardiorespiratory-fitness in healthy elderly. Methods: In a randomized, double-masked, placebo-controlled, parallel-group dietary intervention trial, 68 healthy elderly (55-79 years, 28 female) received either 500 mg of CF or a nutrient-matched control capsule twice a day for 30 days. Primary endpoint was defined as peak oxygen consumption (VO2) in a cardiopulmonary exercise test (CPET). Secondary endpoints were oxygen pulse (VO2/heart rate (HR)), resting blood pressure (BP), and resting vascular function. Results: After 30 days of CF intake peakVO2 increased by 190 ml/min (95% CI 1-371 ml/min) and peakVO2/kg by 2.5 ml/ (min*kg) (95% CI 0.30-4.2 ml/ (min*kg)). O2-pulse increased by 1.7 ml (95% CI 0.29-3.2 ml) and max exercise capacity by 9.6 W (95% CI 2.1-17.7 W). CF decreased resting systolic and diastolic BP by 5.4 mmHg (95% CI -10.7 - -0.1 mmHg) and 2.9 mmHg (95% CI (-) 5.5-(-) 0.4 mmHg), respectively. Flow-mediated vasodilation (FMD) increased by an absolute 1.3% (95% CI 0.76-1.79 %) in the CF group. Indexes of pulmonary function were not affected. No changes for primary and secondary endpoints were detected in control. Conclusion: CF substantially improve markers of cardiorespiratory fitness in healthy elderly humans highlighting their potential to preserve cardiovascular health with increasing age.

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Section: Effectiveness Of Cfs To Improve Vascular Function In Healthy...supporting

confidence: 69%

Cocoa flavanols improve peakVO₂and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Groene

Duse

Kramser

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…55 Overall, dietary interventions have been shown to reestablish disturbed redox signaling in the vasculature. 56 As already demonstrated in the COSMOS trial 57 a 27% lowering in cardiovascular deaths can be achieved through CF intake at half the amount in elderly individuals free from CVD after a 3.6-year follow-up. The amount of dietary CFs given in our study is above the average intake in a typical European diet.…”

Section: Discussionmentioning

confidence: 90%

Cocoa flavanols improve peakVO₂ and exercise capacity in a randomized double blinded clinical trial in healthy elderly people

et al. 2023

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The Role of Oxidants in Percutaneous Coronary Intervention-Induced Endothelial Dysfunction: Can We Harness Redox Signaling to Improve Clinical Outcomes?

Cited by 2 publications

References 152 publications

Cocoa flavanols improve peakVO₂and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Cocoa flavanols improve peakVO₂and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Cocoa flavanols improve peakVO₂ and exercise capacity in a randomized double blinded clinical trial in healthy elderly people

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The Role of Oxidants in Percutaneous Coronary Intervention-Induced Endothelial Dysfunction: Can We Harness Redox Signaling to Improve Clinical Outcomes?

Cited by 2 publications

References 152 publications

Cocoa flavanols improve peakVO2and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Cocoa flavanols improve peakVO2and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Cocoa flavanols improve peakVO2 and exercise capacity in a randomized double blinded clinical trial in healthy elderly people

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Cocoa flavanols improve peakVO₂and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Cocoa flavanols improve peakVO₂and exercise capacity in a randomized double blinded clinical trial in healthy elderly

Cocoa flavanols improve peakVO₂ and exercise capacity in a randomized double blinded clinical trial in healthy elderly people