The role of oral hygiene in head and neck cancer: results from International Head and Neck Cancer Epidemiology (INHANCE) consortium

Hashim, Dana; Sartori, Samantha; Brennan, Paul; Curado, María Paula; Wünsch-Filho, Victor; Divaris, Kimon; Olshan, Andrew F.; Zevallos, José P.; Winn, Deborah M.; Franceschi, Silvia; Castellsagué, Xavier; Lissowska, Jolanta; Rudnai, Péter; Matsuo, Keitaro; Morgenstern, Hal; Chen, Chen X.; Vaughan, Thomas L.; Hofmann, Jonathan N.; D’Souza, Gypsyamber; Haddad, Robert I.; Wu, Huadong; Lee, Y. C.; Hashibe, Mia; Vecchia, Carlo La; Boffetta, Paolo

doi:10.1093/annonc/mdw224

Cited by 119 publications

(118 citation statements)

References 35 publications

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“…Next, there were 13 studies and 2 meta‐analyses that evaluated the association between the number of missing teeth and the head and neck cancer risk . Ten case‐control studies and both meta‐analyses supported that higher proportion of missing teeth increased head and neck cancer risk, which was similar to our study results .…”

Section: Discussionsupporting

confidence: 88%

“…Higher proportions of missing teeth, denture use, and gum bleeding might increase the head and neck cancer risk, and frequent teeth cleaning and regular visits to the dentist might decrease the head and neck cancer risk. Recently, the International Head and Neck Cancer Epidemiology Consortium (INHANCE), in a large‐scale pooled case‐control study, reported significant associations between oral hygiene indicators and head and neck cancer risk after adjustment of potential confounders . Although this article reported on a high impact of oral hygiene on head and neck cancer risk, only one Asian study was included in this study.…”

Section: Introductionmentioning

confidence: 99%

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Impact of oral hygiene on head and neck cancer risk in a Chinese population

Kawakita

Lee

et al. 2017

Head & Neck

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Background Although the impact of oral hygiene on head and neck cancer (HNC) risk has been investigated, few studies have been conducted among Asians. Mehods We conducted a multicenter case-control study to investigate this potential association. We performed unconditional multiple logistic regression models adjusted by potential confounders. Results We observed an inverse association of frequency of dental visits with HNC risk, with an adjusted OR of 3.70 (2.51-5.45) for never dental visits compared with ≥1 time/year (ptrend<0.001). We also observed a positive association between the number of missing teeth and HNC risk, with an adjusted OR for ≥ 5 missing teeth compared with < 5 missing teeth of 1.49 (1.08-2.04). Combining multiple oral hygiene indicators, poor oral hygiene scores increased HNC risk. Conclusions Poor oral hygiene may increase HNC risk in a Chinese population. Improving oral hygiene may contribute to reducing HNC risk in the Chinese population.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Impact of oral hygiene on head and neck cancer risk in a Chinese population

Kawakita

Lee

et al. 2017

Head & Neck

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“…Other factors are also implicated in the etiology of squamous cell head and neck cancer such as poor oral hygiene, [1][2][3][4][5][6] diet, viruses, occupational agents, pollutants, genetic influences, but few case-controlled epidemiological studies have been carried out. Other factors are also implicated in the etiology of squamous cell head and neck cancer such as poor oral hygiene, [1][2][3][4][5][6] diet, viruses, occupational agents, pollutants, genetic influences, but few case-controlled epidemiological studies have been carried out.…”

Section: Introductionmentioning

confidence: 99%

“…9 Oral SCC can be divided into oropharyngeal SCC and oral cavity SCC (OC-SCC). [1][2][3][4][5][6] Poor oral hygiene will result in a change in the oral microbiome of such patients. 10 The recognition of HPV etiology in oropharyngeal SCC has improved the clinical outcomes and led to specific prevention for HPV infection by vaccination.…”

Section: Introductionmentioning

confidence: 99%

Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus

Ganly

Yang

Giese

et al. 2019

Intl Journal of Cancer

110

122

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Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC‐SCC). Many new cases of OC‐SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC‐SCC in nonsmoking HPV negative patients. We compared the oral microbiome of HPV‐negative nonsmoker OC‐SCC(n = 18), premalignant lesions(PML) (n = 8) and normal control patients (n = 12). Their oral microbiome was sampled by oral wash and defined by 16S rRNA gene sequencing. We report that the periodontal pathogens Fusobacterium, Prevotella, Alloprevotella were enriched while commensal Streptococcus depleted in OC‐SCC. Based on the four genera plus a marker genus Veillonella for PML, we classified the oral microbiome into two types. Gene/pathway analysis revealed a progressive increase of genes encoding HSP90 and ligands for TLRs 1, 2 and 4 along the controls→PML → OC‐SCC progression sequence. Our findings suggest an association between periodontal pathogens and OC‐SCC in non smoking HPV negative patients.

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“…Other behavioral risk factors are micronutrient deficiency (=low intake of fresh fruit and vegetables containing antioxidants) (10) and poor oral hygiene (11,12). Viruses constitute the biological risk factors: human papilloma virus (HPV) has been mainly linked to cancer in the oropharynx and tonsils (13,14) and Epstein-Barr-Virus to nasopharynx cancer (15).…”

Section: Etiology and Risk Factorsmentioning

confidence: 99%

The impact of Survivin, WRAP53β, and Hypoxia on treatment response in Head and Neck Cancer

Tiefenböck-Hansson¹

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v ABSTRACTSquamous cell carcinoma (SCC) is the most common histological type of cancer in the head and neck region and arises in the epithelial mucosa of the upper aerodigestive tract.Approximately one and a half million people are living with the diagnosis. Despite efforts in prevention and advances in treatment, the 5-year survival rate still lies around 60%, and recurrences and second primary tumors remain a problem. Moreover, treatment responses vary from patient to patient, highlighting the need for individually tailored treatments. To make this possible, biomarkers predicting treatment outcome are needed to better guide treatment decisions.The aim of this thesis was to evaluate the expression of certain proteins and the frequency of certain SNPs (Single nucleotide polymorphisms) in tumor biopsies and cell cultures of head and neck squamous cell carcinomas (HNSCC), and to explore their potential as biomarkers for treatment outcome. Furthermore, we aimed to study the impact of hypoxia on treatment response, epithelial-to-mesenchymal transition (EMT), and induction of cancer stem cells (CSC).In papers I and II, we investigated two proteins, survivin and WRAP53β, using immunohistochemistry (IHC) in tumor biopsies from 40 patients categorized as Nonresponders or Responders to radiotherapy. High expression of survivin and nuclear expression of WRAP53β were significantly more prevalent in the Responder group. The combination of these two factors correlated strongest to overall survival, but not to a significantly higher extent compared to survivin alone. Moreover, when examined separately, a high percentage of p53-stained cells and the presence of the SNP FGFR4 Gln388Arg correlated to improved overall survival, whereas the SNP XPD Lys751Gln was associated with worse overall survival. The latter three showed no significant correlations to radiotherapy response. In paper III, the two ABSTRACT vi most promising proteins identified in papers I and II were analyzed in a study cohort of 149 tumor biopsies of glottic laryngeal SCC, categorized as T2N0-T3N0. In this patient group, no significant associations between survivin expression and survival could be found. However, expression of cytoplasmic WRAP53β was significantly linked to worse disease-free-survival (DSF) compared to nuclear WRAP53β or negative staining for WRAP53β. Positive expression of p16INK4a was found in 7% of the tumors. The prevalence of p16 INK4a was higher in younger patients (<60) and associated with absence of recurrence and longer DSF.In paper IV, five HNSCC cell lines were cultured in normoxic (20% O 2 ) and hypoxic (1% O 2 )conditions and changes in treatment response, EMT profile, and expression of CSC markers were examined. As expected, hypoxia induced EMT and to a certain extent expression of CSC markers. Silencing of the hypoxia-inducible-factor-1α (HIF-1α) only partly reversed these effects, suggesting that other mechanisms are involved. Whereas most cell lines became more resistant to treatment in hypoxia, one cell line (LK0412) ...

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The role of oral hygiene in head and neck cancer: results from International Head and Neck Cancer Epidemiology (INHANCE) consortium

Abstract: Good oral hygiene, as characterized by few missing teeth, annual dentist visits, and daily tooth brushing, may modestly reduce the risk of HNC.

Cited by 119 publications

References 35 publications

Impact of oral hygiene on head and neck cancer risk in a Chinese population

Impact of oral hygiene on head and neck cancer risk in a Chinese population

Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus

The impact of Survivin, WRAP53β, and Hypoxia on treatment response in Head and Neck Cancer

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