Impact of oral hygiene on head and neck cancer risk in a Chinese population

Kawakita, Daisuke; Lee, Yuan Chin Amy; Li, Qian; Chen, Yuji; Chen, Chien Jen; Hsu, Wei-Li; Lou, Pei‐Jen; Zhu, Cairong; Pan, Jian; Shen, Hongbing; Ma, Hongxia; Cai, Lin; He, Baochang; Wang, Yu; Zhou, Xiaoyan; Ji, Qinghai; Zhou, Baosen; Wu, Wei; Ma, Jie; Boffetta, Paolo; Zhang, Zuo‐Feng; Dai, Min; Hashibe, Mia

doi:10.1002/hed.24929

Cited by 16 publications

(13 citation statements)

References 32 publications

(79 reference statements)

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“…NPRO levels in saliva of subjects with POH were found to be higher (190 μg NPRO/L) compared to those with good oral hygiene (24 μg NPRO/L) [50]. A case-control study assessing the oral conditions as risk factors for oral cancers found that the participants who smoked tobacco had greater missing teeth, representing POH were at greater risk of having oral cancer (OR = 7.3) than those who had a maintained oral hygiene and smoked tobacco (OR = 2.0) [21]. Thus, formation of nitrosamines is more extensive in tobacco users who have POH than those with better oral hygiene, thereby increasing the carcinogenic potential of tobacco.…”

Section: Arecanut Tobacco and Alcoholmentioning

confidence: 99%

“…Poor oral hygiene and alcohol: Alcohol is a known carcinogen involved in causation of oral cancer [51,52]. A Chinese case-control study found that subjects who consumed alcohol and had POH (represented by inadequate dentition) had 5 times more risk of having oral cancer (OR = 9.1, 95% CI = 4.4-19) than those who just consumed alcohol but maintained a good oral hygiene (OR = 1.8, 95% CI = 0.7-4.7) [21]. According to a case-control study, the attributable risk percentage for causing OSCC due to alcohol consumption was 26% while that due to POH was 32%.…”

Section: Arecanut Tobacco and Alcoholmentioning

confidence: 99%

“…There was a hospital based case-control study where they had adjustment done for ethnicity, education level, tobacco smoking, betel quid chewing, alcohol drinking, etc. [23]. They compared 921 cases of HNC and 806 controls.…”

Section: Studies With Adjustment Of Confounding Factorsmentioning

confidence: 99%

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Role of Poor Oral Hygiene in Causation of Oral Cancer—a Review of Literature

Mathur

Singhavi

Malik

et al. 2018

Indian J Surg Oncol

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Oral squamous cell carcinomas (OSCC) are among the commonest cancers in South East Asia and more so in the Indian subcontinent. The role of tobacco and alcohol in the causation of these cancers is well-documented. Poor oral hygiene (POH) is often seen to co-exist in patients with OSCC. However, the role of poor oral hygiene in the etio-pathogenesis of these cancers is controversial. We decided to evaluate the available literature for evaluating the association of POH with OSCC. A thorough literature search of English-language articles in MEDLINE, PubMed, Cochrane Database of Systematic Reviews, and Web of Science databases was conducted, and 93 relevant articles were short-listed. We found that POH was strongly associated with oral cancers. It aids the carcinogenic potential of other known carcinogens like tobacco and alcohol. Even on adjusting for known confounding factors like tobacco, alcohol use, education, and socioeconomic strata, presence of POH exhibits higher odds of developing oral cancer.

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Section: Arecanut Tobacco and Alcoholmentioning

confidence: 99%

Section: Arecanut Tobacco and Alcoholmentioning

confidence: 99%

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Role of Poor Oral Hygiene in Causation of Oral Cancer—a Review of Literature

Mathur

Singhavi

Malik

et al. 2018

Indian J Surg Oncol

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“…Previous studies reported that poor oral health, loss of multiple teeth, and infrequent tooth brushing are related to the risk of upper aerodigestive tract cancers including in the lips, oral cavity, oropharynx, hypopharynx, larynx, and esophagus [15,16]. Moreover, other casecontrol and cross-sectional studies, less frequent dental visits, having periodontal disease, infrequent tooth brushing, and large number of tooth loss were shown to be associated with increased risk of head and neck cancer [17,18]. Recent one meta-analysis showed that infrequent dental visits was increased in head and neck cancer patients [19].…”

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confidence: 94%

Improving oral hygiene may attenuate occurrence of head and neck cancer: nation-wide population based cohort study.

Woo¹,

Lee

et al. 2020

Preprint

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Background: In previous case-control and cross-sectional studies, less frequent dental visits, infrequent tooth brushing, presence of periodontal disease, and increased number of tooth loss were shown to be associated with increased risk of head and neck cancer. However, studies regarding the association of periodontal disease and parameters of oral health with occurrence of head and neck cancer have been lacking particularly in longitudinal setting. We aimed to investigate the relationship between parameters of oral health and risk of head and neck cancer in a nationwide general population-based cohort.Methods : We included 150,774 subjects from the Korean National Health Insurance System-Health Screening Cohort for demographics, past history, and laboratory findings. The presence of periodontal disease and parameters of oral health including frequency of tooth brushings, dental visit for any reason, expertised dental cleaning, and number of tooth loss were investigated. Head and neck cancer was defined as International Statistical Classification of Diseases-10 codes of ‘C00-C14’.Results: During median 11.1 years of follow-up, 1,155 (0.76%) head and neck cancers occurred. Based on multivariable analysis, after adjusting for demographics, alcohol intake, smoking, regular exercise, body mass index, systolic blood pressure, blood and urinary laboratory findings, and parameters of oral health, frequent tooth brushing (more than three times per day) was related to lower risk of head and neck cancer (hazard ratio, HR: 0.78, 95% confidence interval, CI: 0.66–0.93, p=0.005). Increased number of tooth loss was positively associated with occurrence of head and neck cancer (p value for trend test for HR <0.001).Conclusions : The occurrence of head and neck cancer was decreased with the more frequent tooth brushing (more than three times per day) and increased with the number of tooth loss. In regards of head and neck cancer prevention, improving oral hygiene may have significant contribution.

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“…Cancer of the oral cavity is one of the leading causes of cancer-associated mortality in Taiwan; patients with oral cancer generally have a poor prognosis and experience high rates of mortality ( 1 , 2 ). In Taiwan, oral cancer is the fifth leading cause of cancer-associated mortality, according to the 2016 annual report by the Ministry of Health and Welfare (Taiwan, R.O.C.)…”

Section: Introductionmentioning

confidence: 99%

Pterostilbene modulates the suppression of multidrug resistance proteinï¿½1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling

Chang

Chiang³

et al. 2018

Int J Oncol

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Pterostilbene is a natural polyphenolic compound that is primarily found in fruits, such as blueberries and has a similar structure to resveratrol. Pterostilbene exhibits antioxidant, anti-inflammatory and antitumor activity but the effects of pterostilbene on drug-resistant oral cancer cells and its underlying mechanisms of action have not yet been explored. Therefore, the present study was performed to clarify the anticancer effects of pterostilbene on cisplatin-resistant human oral cancer CAR cells. The results demonstrated that CAR cells exhibited marked shrinkage, cell membrane breakage and autophagic vacuole formation following treatment with pterostilbene. Pterostilbene also effectively inhibited cell viability and suppressed cell confluence in a time- and concentration-dependent manner. Probing with acridine orange, monodansylcadaverine and LysoTracker Red demonstrated that the number of acidic vesicular organelles was increased, indicating increased autophagy. Furthermore, Heochst 33342 staining determined that DNA condensation, a characteristic of apoptosis, was enhanced following treatment with pterostilbene. Furthermore, pterostilbene upregulated mRNA levels of LC3-II and Atg12, as well as the expression of Atgs/Beclin-1/LC3-associated signaling, suggesting that it enhances autophagy. The autophagy inhibitors 3-methyladenine and chloroquine were used to confirm that pterostilbene induces autophagy. It was also determined that pterostilbene triggered caspase-dependent apoptosis by directly testing DNA breakage and using the pan-caspase inhibitor carbobenzoxyvalyl-alanyl-aspartyl fluoromethyl ketone. The results demonstrated that pterostilbene mediates the apoptosis of CAR cells via the intrinsic apoptotic cascade. In addition, pterostilbene inhibited MDR1 expression and the phosphorylation of AKT on the Ser473 site in CAR cells. Therefore, pterostilbene may elicit an oral anticancer response in drug-resistant cells and may be used as a chemotherapeutic adjuvant to treat patients with oral cancer.

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Impact of oral hygiene on head and neck cancer risk in a Chinese population

Cited by 16 publications

References 32 publications

Role of Poor Oral Hygiene in Causation of Oral Cancer—a Review of Literature

Role of Poor Oral Hygiene in Causation of Oral Cancer—a Review of Literature

Improving oral hygiene may attenuate occurrence of head and neck cancer: nation-wide population based cohort study.

Pterostilbene modulates the suppression of multidrug resistance proteinï¿½1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling

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