The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

Du, Jing; Zhu, Ming; Bao, Hongkun; Li, Bai; Dong, Yilong; Xiao, Chunjie; Zhang, Grace Y.; Henter, Ioline D.; Rudorfer, Matthew V.; Vitiello, Benedetto

doi:10.1080/10408398.2013.876960

Cited by 82 publications

(44 citation statements)

References 186 publications

(230 reference statements)

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“…Other pro-inflammatory dietary factors include excess of food with simple sugars and meat high in SFA and trans fats, as discussed above. Moreover, there are several nutrients of which stress-related deficiency has been linked with some psychological disorders, like depression, post-traumatic stress disorder, and suicidal attempts, as reviewed recently [118]. Besides n-3 PUFAs, these include antioxidant nutrients, like vitamin C, E, carotenoids and selenium, vitamins from the B group (folic acid and B 12 ), and magnesium and zinc.…”

Section: Effects Of Chronic Stress and Lgci Magnified By Proinflammatmentioning

confidence: 99%

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

Ilich

Gilman²,

Cvijetić

et al. 2020

Nutrients

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Chronic stress and low-grade chronic inflammation (LGCI) are key underlying factors for many diseases, including bone and body composition impairments. Objectives of this narrative review were to examine the mechanisms by which chronic stress and LGCI may influence osteosarcopenic adiposity (OSA) syndrome, originally named as ostoesarcopenic obesity (OSO). We also examined the crucial nutrients presumed to be affected by or cause of stress and inflammation and compared/contrasted them to those of our prehistoric ancestors. The evidence shows that stress (particularly chronic) and its related inflammatory processes, contribute to osteoporosis, sarcopenia, and adiposity ultimately leading to OSA as a final and most deranged state of body composition, commencing at the mesenchymal cell lineage disturbance. The foods/nutrients consumed by modern humans, as well as their altered lifestyle, also contribute to stress, LGCI and subsequently to OSA. The processes can also go in opposite direction when stress and inflammation impact nutritional status, particularly some micronutrients’ levels. While nutritional management of body composition and LGCI have been studied, the nutrients (and their quantities) most affected by stressors and those which may act toward the alleviation of stressful state, ultimately leading to better body composition outcomes, need to be elucidated.

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Section: Effects Of Chronic Stress and Lgci Magnified By Proinflammatmentioning

confidence: 99%

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

Ilich

Gilman²,

Cvijetić

et al. 2020

Nutrients

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“…Further reviews also displayed a positive effect on depression [56,57]. A review of patients with depression and PTSD found improvements in neurocognitive functioning and benefits for depressive symptoms and suicidality [58]. Trebatikáa et al found a surplus for patients with comorbid cardiovascular disease and depression [59].…”

Section: Other Supplementsmentioning

confidence: 99%

“…As a natural source of PUFA, fish oil, combined with a Mediterranean diet, also had a positive effect on depression [60]. Administration of supplements like DHA, PUFA, and fish oil showed a positive effect therapeutical approach, inflammatory factors, pathophysiology, and pathoetiology of depression [49][50][51][52][53][54][55][56][57][58][59][60].…”

Section: Other Supplementsmentioning

confidence: 99%

The Role of Dietary Supplements in Depression and Anxiety – A Narrative Review

Hoffmann

Emons

Brunnhuber³

et al. 2019

Pharmacopsychiatry

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Introduction Dietary supplements are very widely used in the general population and there is a growing market for them, which is against the recommendations of the German Society for Nutrition. There is some evidence that dietary supplements are useful additions in the treatment of psychiatric disorders. This review is an overview of available practical knowledge regarding the use of supplements in psychiatric treatment. In particular, the review focused on the diagnosis of depression and anxiety in terms of supplement treatment. Methods This is a narrative review of the evidence regarding supplements for treating anxiety and depression. We searched PubMed to 2018. Two reviewers screened the citations and abstracted the data. Phytopharmaceutical attends and animal-based data were excluded. Results There are strong indications regarding the impact of supplements on the selected psychiatric disorders, but at this time, there only a few randomized clinical studies available, so evidence for these findings is quite low. However, it must be noted that there are strong hints for a relationship between vitamin D level and depression. Furthermore, various supplements have got potentially an influence on the characteristics of depression. Discussion This review summarizes the current knowledge about supplements when used for some psychiatric conditions, but the data does not provide compelling evidence in any direction. There are only indications that there is an influence of supplements on psychiatric diseases. In support of this, there is further need for high-quality studies in this field. Reviews on other diagnoses, such as schizophrenia and dementia, will be part of further work.

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“…Glukokortikoid dapat menurunkan sistem imunitas tubuh yang terlihat pada gambaran deferensial leukosit (Zulkifli et al 2000). Dengan pemberian vitamin B-kompleks dapat mengurangi stress karena vitamin B-kompleks terutama vitamin B1 dapat memperbaiki fungsi sinyal neurotransmitter dan mitokondria sel (Du et al 2014) serta mampu memproduksi substansi yang dapat mengurangi stress (Fattal-Valevski 2011).…”

Section: Gambar 1 Grafik Efektivitas Vitamin B-kompleks Pada Induk Sunclassified

Efektivitas Vitamin B-Kompleks terhadap Gambaran Hematologi Sapi Bali Bunting dan Post-Partus

Astiti¹,

Hijriah²

2017

Teknologi Peternakan Dan Veteriner Mendukung Diversifikasi Sumber Protein Asal Ternak

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The current study intended to investigate the efectivity of vitamin B-complex administration on pregnant and post partus Bali Cattle. The B-complex is an essential vitamin that required for metabolic process for pregnant and post partus cattle. In this study, 10 pregnant Bali Cattle which has average of 5.5±1.65 months of gestation and 11 post partus Bali Cattle with average of 1.3±0.7 months of calves age have selected for treatment. Before giving the vitamin B-complex treatment, the blood samples was taken from the first group of treated Bali Cattle (T0), while the blood sample from the second group (T2) was taken 30 days after treatment. The 10 ml/cattle dosage of vitamin B-complex was intra muscularly (IM) injected. The result showed that the red blood cell (RBC), haemoglobin (HGB) and hematocrit values of the pregnant Bali cattle has decreased on T1 to the level of 13.12, 19.66 and 18.76% respectively (P>0.05). In contrary, the WBC value increased to 14.5% on both T0 and T1. On post partus samples the values of the RBC, HGB and hematocrit of T1 group has experienced an increasing to the level of 15.54%; 27.10% and 23.03% respectively (P>0.05) with WBC value decrease to 28.57% (P>0.05) on T0 treatment. It can be concluded that vitamin B-complex can improve physiological status of post partus Bali Cattle, however a good feed management must be included on pregnant Bali cattle.

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The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

Cited by 82 publications

References 186 publications

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation

The Role of Dietary Supplements in Depression and Anxiety – A Narrative Review

Efektivitas Vitamin B-Kompleks terhadap Gambaran Hematologi Sapi Bali Bunting dan Post-Partus

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