The Role of Noncoding RNA in the Pathophysiology and Treatment of Premature Ovarian Insufficiency

Pankiewicz, Katarzyna; Laudański, Piotr; Issat, Tadeusz

doi:10.3390/ijms22179336

Cited by 15 publications

(7 citation statements)

References 100 publications

(124 reference statements)

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“…They do not translate proteins, but can regulate gene expression by silencing mRNA translation and causing target mRNA degradation [ 97 , 98 ]. There is a vast body of evidence for a crucial role of miRNAs in the development and potential treatment of many diseases, including reproductive health diseases, such as premature ovarian insufficiency (POI), polycystic ovarian syndrome (PCOS) and infertility, as well as pregnancy complications (i.e., preeclampsia and fetal growth restriction) [ 99 , 100 , 101 , 102 , 103 ].…”

Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. It is associated with a significant deterioration in quality of life as a result of chronic pelvic pain and may also lead to infertility. One of the most serious complications of endometriosis is an ectopic pregnancy (EP). Currently, the exact mechanism explaining this phenomenon is unknown; therefore, there are no effective methods of prevention. It is assumed that the pathogenesis of EP is influenced by abnormalities in the contraction of the fallopian tube muscles, the mobility of the cilia, and in the fallopian microenvironment. Endometriosis can disrupt function on all three levels and thus contribute to the implantation of the embryo beyond the physiological site. This review takes into account aspects of the molecular mechanisms involved in the pathophysiology of endometriosis and EP, with particular emphasis on the similarities between them.

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Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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“…ncRNAs are associated with the development of many diseases and can be divided into small RNAs and lncRNAs depending on their length. LncRNAs have functions as molecular scaffolds for chromatin and miRNA sponges, translating and degrading RNAs that are involved in the development of most diseases ( 37 ). As a type of small ncRNA, miRNA regulates gene expression mainly by silencing mRNA translation and degrading mRNA.…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Molecular Mechanism Related to Infertile Endometriosis

Guo

Zhang

et al. 2022

Front. Vet. Sci.

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ObjectivesIn this research, we aim to explore the bioinformatic mechanism of infertile endometriosis in order to identify new treatment targets and molecular mechanism.MethodsThe Gene Expression Omnibus (GEO) database was used to download MRNA sequencing data from infertile endometriosis patients. The “limma” package in R software was used to find differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was used to classify genes into modules, further obtained the correlation coefficient between the modules and infertility endometriosis. The intersection genes of the most disease-related modular genes and DEGs are called gene set 1. To clarify the molecular mechanisms and potential therapeutic targets for infertile endometriosis, we used Gene Ontology (GO), Kyoto Gene and Genome Encyclopedia (KEGG) enrichment, Protein-Protein Interaction (PPI) networks, and Gene Set Enrichment Analysis (GSEA) on these intersecting genes. We identified lncRNAs and miRNAs linked with infertility and created competing endogenous RNAs (ceRNA) regulation networks using the Human MicroRNA Disease Database (HMDD), mirTarBase database, and LncRNA Disease database.ResultsFirstly, WGCNA enrichment analysis was used to examine the infertile endometriosis dataset GSE120103, and we discovered that the Meorangered1 module was the most significantly related with infertile endometriosis. The intersection genes were mostly enriched in the metabolism of different amino acids, the cGMP-PKG signaling pathway, and the cAMP signaling pathway according to KEGG enrichment analysis. The Meorangered1 module genes and DEGs were then subjected to bioinformatic analysis. The hub genes in the PPI network were performed KEGG enrichment analysis, and the results were consistent with the intersection gene analysis. Finally, we used the database to identify 13 miRNAs and two lncRNAs linked to infertility in order to create the ceRNA regulatory network linked to infertile endometriosis.ConclusionIn this study, we used a bioinformatics approach for the first time to identify amino acid metabolism as a possible major cause of infertility in patients with endometriosis and to provide potential targets for the diagnosis and treatment of these patients.

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“…These include cell division and differentiation, stress response, tissue remodeling, and disease states, including pregnancy disruption/loss [39,42]. Thus, changes in the expression of miRNA molecules may affect the various states of pregnancy pathology, which may include preeclampsia, premature birth, macrosomia, or low birth weight [39][40][41][42][43][44][45][46].…”

Section: Microrna Biogenesismentioning

confidence: 99%

The role of miRNA molecules in the miscarriage process

Omeljaniuk

Laudański

Miltyk

2023

Biology of Reproduction

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The etiology and pathogenesis of miscarriage, which is the most common pregnancy complication, have not been fully elucidated. There is a constant search for new screening biomarkers that would allow for the early diagnosis of disorders associated with pregnancy pathology. The profiling of miRNA expression is a promising research area, which can help establish the predictive factors for pregnancy diseases. Molecules of miRNAs are involved in several processes crucial for the development and functioning of the body. These processes include cell division and differentiation, programmed cell death, blood vessel formation or tumorigenesis, and the response to oxidative stress. MiRNAs affect the number of individual proteins in the body due to their ability to regulate gene expression at the post-transcriptional level, ensuring the normal course of many cellular processes. Based on the scientific facts available, this paper presents a compendium on the role of miRNA molecules in the miscarriage process. The expression of potential miRNA molecules as early minimally invasive diagnostic biomarkers may be evaluated as early as the first weeks of pregnancy, and may constitute a monitoring factor in the individual clinical care of women in early pregnancy, especially after the first miscarriage. To summarize, the described scientific data set a new direction of research in the development of preventive care and prognostic monitoring of the course of pregnancy.

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The Role of Noncoding RNA in the Pathophysiology and Treatment of Premature Ovarian Insufficiency

Cited by 15 publications

References 100 publications

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Identification of Potential Molecular Mechanism Related to Infertile Endometriosis

The role of miRNA molecules in the miscarriage process

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