The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders

Tripathi, Manish Kumar; Kartawy, Maryam; Amal, Haitham

doi:10.1016/j.redox.2020.101567

Cited by 91 publications

(65 citation statements)

References 201 publications

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“…NOS2 rs2297518 is a functional polymorphism that affects the iNOS protein activity, with the A allele related to increased protein activity and higher nitric oxide (NO) production [ 26 , 27 ]. NO has been reported as playing major roles in neurogenesis and neurodevelopment, and its dosage is extremely important [ 28 , 29 ]. The dysregulation of NO has been involved in the progression of many neurodevelopmental, neurobehavioral, and neurodegenerative disorders [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…NO has been reported as playing major roles in neurogenesis and neurodevelopment, and its dosage is extremely important [ 28 , 29 ]. The dysregulation of NO has been involved in the progression of many neurodevelopmental, neurobehavioral, and neurodegenerative disorders [ 29 ]. In this sense, the dysregulation of NO during ZIKV infection, caused both by the host response to the virus and by the individual’s genotype, could affect the development process causing a congenital anomaly.…”

Section: Discussionmentioning

confidence: 99%

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Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

Gomes

Sgarioni

Boquett

et al. 2021

Viruses

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Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in utero exposed to ZIKV infection, but born without congenital anomalies, were evaluated. Children with CZS were predominantly infected by ZIKV in the first trimester (p < 0.001) and had mothers with lower educational level (p < 0.001) and family income (p < 0.001). We found higher risk of CZS due the allele rs2297518[A] of NOS2 (OR = 2.28, CI 95% 1.17–4.50, p = 0.015). T allele and TT/CT genotypes of the TNF rs1799724 and haplotypes associated with higher expression of TNF were more prevalent in children with CZS and severe microcephaly (p = 0.029, p = 0.041 and p = 0.030, respectively). Our findings showed higher risk of CZS due ZIKV infection in the first trimester and suggested that polymorphisms in NOS2 and TNF genes affect the risk of CZS and severe microcephaly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

Gomes

Sgarioni

Boquett

et al. 2021

Viruses

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“…HCl-acidified drinking water also caused pronounced alterations in the serum metabolome. Serum arginine level was elevated 133-fold, which indicates increased production of nitric oxide and polyamines [51][52][53][54] that are important modulators of neuronal activity 55,56 . HCl-acidified drinking water caused a 43-fold increase in the serum level of palmitic amide, a primary fatty acid amide derived from palmitic acid (C16:0).…”

Section: Discussionmentioning

confidence: 99%

The acidified drinking water-induced changes in the behavior and gut microbiota of wild-type mice depend on the acidification mode

Whipple

Agar

Zhao

et al. 2021

Sci Rep

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Acidification of drinking water to a pH between 2.5 and 3.0 is widely used to prevent the spread of bacterial diseases in animal colonies. Besides hydrochloric acid (HCl), sulfuric acid (H2SO4) is also used to acidify drinking water. Here we examined the effects of H2SO4-acidified drinking water (pH = 2.8) received from weaning (postnatal day 21) on the behavior and gut microflora of 129S6/SvEv mice, a mouse strain commonly used in transgenic studies. In contrast to HCl-acidified water, H2SO4-acidified water only temporarily impaired the pole-descending ability of mice (at 3 months of age), and did not change the performance in an accelerating rotarod test. As compared to 129S6/SvEv mice receiving non-acidified or HCl-acidified drinking water, the gut microbiota of 129S6/SvEv mice on H2SO4-acidified water displayed significant alterations at every taxonomic level especially at 6 months of age. Our results demonstrate that the effects of acidified drinking water on the behavior and gut microbiota of 129S6/SvEv mice depends on the acid used for acidification. To shed some light on how acidified drinking water affects the physiology of 129S6/SvEv mice, we analyzed the serum and fecal metabolomes and found remarkable, acidified water-induced alterations.

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“…In addition, disturbances in proper nNOS expression and/or NO signaling have also been associated with major depressive disorder, bipolar disorder, schizophrenia, addiction, and epilepsy. Moreover, many of these disorders present defects in dendritic branching and contain an important sex component (reviewed in Kulkarni & Firestein, 2012; Tripathi et al., 2020; Zhou et al, 2018). The following sections will address the role for nNOS in the developing nervous system, the role for nNOS in dendritic branching, and sex differences in dendritic branching as it pertains to NO.…”

Section: No In the Nervous Systemmentioning

confidence: 99%

Nitric oxide and sex differences in dendritic branching and arborization

Richards

Schonhoff

2021

J of Neuroscience Research

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Nitric oxide (NO) is an important signaling molecule with many functions in the nervous system. Derived from the enzymatic conversion of arginine by several nitric oxide synthases (NOS), NO plays significant roles in neuronal developmental events such as the establishment of dendritic branching or arbors. A brief summary of the discovery, molecular biology, and chemistry of NO, and a description of important NO-mediated signal transduction pathways with emphasis on the role for NO in the development of dendritic branching during neurodevelopment are presented. Important sex differences in neuronal nitric oxide synthase expression during neuronal development are considered. Finally, a survey of endogenous and exogenous substances that disrupt dendritic patterning is presented with particular emphasis on how these molecules may drive NO-mediated sex differences in dendritic branching.

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The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders

Cited by 91 publications

References 201 publications

Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

The acidified drinking water-induced changes in the behavior and gut microbiota of wild-type mice depend on the acidification mode

Nitric oxide and sex differences in dendritic branching and arborization

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