Nitric oxide and sex differences in dendritic branching and arborization

Richards, Laura A.; Schonhoff, Christopher M.

doi:10.1002/jnr.24789

Cited by 6 publications

(9 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these free radicals have to be present in optimal concentrations conducive to the normal functioning of the body system [8]. Moreover, it is well known that nitric oxide is an important neurotransmitter in the nervous system, at least when present in suitable non-toxic levels [9][10][11]. Studies from our laboratory have also shown that NO enhances insulin release from the pancreas [12,13].…”

Section: Introduction 1oxidative Stressmentioning

confidence: 90%

Nociceptin Increases Antioxidant Expression in the Kidney, Liver and Brain of Diabetic Rats

Adeghate

D’Souza

Saeed

et al. 2021

Biology

View full text Add to dashboard Cite

Nociceptin (NC) consists of 17 amino acids (aa) and takes part in the processing of learning and memory. The role of NC in the induction of endogenous antioxidants in still unclear. We examined the effect of NC on the expression of endogenous antioxidants in kidney, liver, cerebral cortex (CC), and hippocampus after the onset of diabetes mellitus, using enzyme-linked immunosorbent assay and immunohistochemistry. Exogenous NC (aa chain 1–17; 10 µg/kg body weight) was given intraperitoneally to normal and diabetic rats for 5 days. Our results showed that catalase (CAT) is present in the proximal (PCT) and distal (DCT) convoluted tubules of kidney, hepatocytes, and neurons of CC and hippocampus. The expression of CAT was significantly (p < 0.05) reduced in the kidney of normal and diabetic rats after treatment with NC. However, NC markedly (p < 0.001) increased the expression CAT in the liver and neurons of CC of diabetic rats. Superoxide dismutase (SOD) is widely distributed in the PCT and DCT of kidney, hepatocytes, and neurons of CC and hippocampus. NC significantly (p < 0.001) increased the expression of SOD in hepatocytes and neurons of CC and the hippocampus but not in the kidney. Glutathione reductase (GRED) was observed in kidney tubules, hepatocytes and neurons of the brain. NC markedly increased (p < 0.001) the expression of GRED in PCT and DCT cells of the kidney and hepatocytes of liver and neurons of CC. In conclusion, NC is a strong inducer of CAT, SOD, and GRED expression in the kidney, liver and brain of diabetic rats.

show abstract

Section: Introduction 1oxidative Stressmentioning

confidence: 90%

Nociceptin Increases Antioxidant Expression in the Kidney, Liver and Brain of Diabetic Rats

Adeghate

D’Souza

Saeed

et al. 2021

Biology

View full text Add to dashboard Cite

show abstract

“…[6] NO is also a potential mediator of non-adrenergic-non-cholinergic (NANC) neurons and therefore could regulate the cardiac contractility and heart rate, gastrointestinal motility, bronchial tone, and erection. [1,3] nitric oxide is a lipophilic free radical so it can easily cross cell membranes [7]. Therefore, it can be assumed that nitric oxide is present throughout the cerebral tissue, but nitric oxide is an unstable molecule in the body and is immediately converted to stable compounds such as nitrite and nitrate [8].…”

Section: Introductionmentioning

confidence: 99%

“…Derived NO from endothelial cell’s eNOS is also an important factor for cerebral blood flow. In cardiovascular system[1,3], NO is responsible for controlling blood pressure by relaxing smooth muscle and vasodilation. [4]…”

Section: Introductionmentioning

confidence: 99%

“…NO is also a potential mediator of non-adrenergic-non-cholinergic (NANC) neurons and therefore could regulate the cardiac contractility and heart rate, gastrointestinal motility, bronchial tone, and erection. [1,3]…”

Section: Introductionmentioning

confidence: 99%

“…[2] Derived NO from endothelial cell's eNOS is also an important factor for cerebral blood flow. In cardiovascular system [1,3], NO is responsible for controlling blood pressure by relaxing smooth muscle and vasodilation. [4] In neurons and glial cells, nNOS is involved in regulating cerebrovascular blood flow, memory and learning (through its long term effects on the CNS).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Morphological evaluation of rat cerebellum following administration of nitrogen monoxide precursor and inhibitor

Chegini

Gholamzad

et al. 2022

Preprint

View full text Add to dashboard Cite

In this study, the quantitative and qualitative effects of nitrogen monoxide on cerebellar histo-pathology, by increasing or decreasing in vivo production of this substance, were investigated. In this study, forty Wistar female rats (RAT) with a weight of about 200 to 250 grams and an av-erage age of eight weeks were used. Rats were divided into five groups of eight, including control groups, normal saline, L-NAME, L-Arginine, L-NAME + L-Arginine. On the third, fourth and fifth days, the injection was performed intraperitoneally and on the eighteenth day, after anesthesia with ether and then craniotomy, the brain and cerebellum of the animals were removed and After quantitative measurements including weight and volume, organs were fixed in 10% formalin and after tissue preparation steps, to prepare the slide, sections with a thickness of 5 to 6 microns were prepared from the samples and by general method such as Hematoxylin-eosin and special techniques like Mason trichrome and toluidine blue were stained and evaluated. The results of this study show that in the case of cerebellum, there is no significant difference in the quantitative weight parameter between the control groups, normal saline, L-Arg, L-NAME and L-NAME + L-Arg groups. Regarding the volume parameter, a significant increase (P <0.01) was observed in L-Arg group compared to L-NAME, L-Arg + L-NAME and normal saline groups. In microscopic qualitative parameters, the most changes in the L-Arg group were seen as follows: The granular and molecular layers of the cerebellum became slightly thickened, some of the nuclei in the granular and molecular layers became severely hyperchromatized, and Purkinje cell accumulation was seen with lymphocytic invasion. In the other groups, there were no significant changes. It is inferred from this study that L-Arginine can cause histopathological changes in cerebellar tissue by increasing NO levels in cerebellum. However, in this study, unlike other similar studies, L-NAME injection did not cause significant histopathological change.

show abstract

The Dendrite Arbor of Purkinje Cells Is Altered Following to Tail Regeneration in the Leopard Gecko

Bradley

Howe

Bailey

et al. 2021

Integrative and Comparative Biology

View full text Add to dashboard Cite

Purkinje cells of the cerebellum have a complex arborized arrangement of dendrites and are amongst the most distinctive cell types of the nervous system. Although the neuromorphology of Purkinje cells has been well described for some mammals and teleost fish, for most vertebrates less is known. Here we used a modified Golgi-Cox method to investigate the neuromorphology of Purkinje cells from the lizard Eublepharis macularius, the leopard gecko. Using Sholl and Branch Structure Analyses, we sought to investigate whether the neuromorphology of gecko Purkinje cells was altered is response to tail loss and regeneration. Tail loss is an evolved mechanism commonly used by geckos to escape predation. Loss of the tail represents a significant and sudden change in body length and mass, which is only partially recovered as the tail is regenerated. We predicted that tail loss and regeneration would induce a quantifiable change in Purkinje cell dendrite arborization. Post hoc comparisons of Sholl analyses data showed that geckos with regenerated tails have significant changes in dendrite diameter and the number of dendrite intersections in regions corresponding to the position of parallel fiber synapses. We propose that the neuromorphological alterations observed in gecko Purkinje cells represent a compensatory response to tail regrowth, and perhaps a role in motor learning.

show abstract

Nitric oxide and sex differences in dendritic branching and arborization

Cited by 6 publications

References 104 publications

Nociceptin Increases Antioxidant Expression in the Kidney, Liver and Brain of Diabetic Rats

Nociceptin Increases Antioxidant Expression in the Kidney, Liver and Brain of Diabetic Rats

Morphological evaluation of rat cerebellum following administration of nitrogen monoxide precursor and inhibitor

The Dendrite Arbor of Purkinje Cells Is Altered Following to Tail Regeneration in the Leopard Gecko

Contact Info

Product

Resources

About