The aim of the current study was to explore the role of dorsal foot skin on the joint kinematics of gait during level walking. Twelve volunteers experienced sensory perturbations with either reduced dorsal skin feedback using topical anesthetic, reduced visual feedback of the lower visual field, or a combination of both cutaneous and visual reductions (paired). The visual condition was introduced to impose a greater reliance on skin input (goggles occluded lower visual field input). Our results showed that a reduction in skin input, alone, resulted in significant angular position changes at both the ankle and knee joints through swing (increased flexion, p < 0.010), despite preservation of minimal toe clearance (MTC; p = 0.908). Conversely, a reduction in lower visual field input resulted in a greater minimal toe clearance affect (MTC; p < 0.001), a slight increase in dorsiflexion at the ankle (p = 0.046), yet no effect on angular position changes for the knee (p = 0.110). The locomotor changes observed following a reduction in cutaneous feedback from the foot dorsum suggest an important role of the skin over this region for the regulation of level ground walking. Interestingly, it appears that these healthy young adults were able to compensate for the reduced skin information while preserving locomotor efficiency via a maintained ground clearance (MTC). Our data also demonstrated an interaction between skin and visual inputs; vision appears to have a less dominant role compared to skin in controlling the joint positions through swing phase of gait. This work is the first to highlight the influence of reduced cutaneous input from the dorsum of the foot on locomotor strategies.
Amongst tetrapods, mechanoreceptors on the feet establish a sense of body placement and help to facilitate posture and biomechanics. Mechanoreceptors are necessary for stabilizing the body while navigating through changing terrains or responding to a sudden change in body mass and orientation. Lizards such as the leopard gecko (Eublepharis macularius) employ autotomy – a voluntary detachment of a portion of the tail, to escape predation. Tail autotomy represents a natural form of significant (and localized) mass loss. Semmes-Weinstein monofilaments were used to investigate the effect of tail autotomy (and subsequent tail regeneration) on tactile sensitivity of each appendage of the leopard gecko. Prior to autotomy, we identified site-specific differences in tactile sensitivity across the ventral surfaces of the hindlimbs, forelimbs, and tail. Repeated monofilament testing of both control (tail-intact) and tail loss geckos had a significant sensitization effect (i.e., decrease in tactile threshold, maintained over time) in all regions of interest except the palmar surfaces of the forelimbs in post-autotomy geckos, compared to baseline testing. Although the regenerated tail is not an exact replica of the original, tactile sensitivity is shown to be effectively restored at this site. Re-establishment of tactile sensitivity on the ventral surface of the regenerate tail points towards a (continued) role in predator detection.
Precise control of the ankle is required to safely clear the ground during walking. Skin input contributes to proprioception about the ankle joint, during both passive movements and level walking. How skin might contribute to proprioceptive control of the ankle during a more complex functional task such as obstacle avoidance is unknown. The purpose of this study was to investigate skin contribution from the dorsum of the ankle joint to safely cross an obstacle, and examine the interaction between vision and skin. It was hypothesized that the lead and trail limbs would be influenced primarily by visual information and skin cues, respectively. Eleven healthy adults crossed an obstacle with either (1) intact sensory input (control) (2) reduced skin input using a topical anesthetic (anesthesia), (3) reduced visual input of the lower half of the visual field (partial vision) or (4) simultaneous reduction of skin and vision (paired). Kinematic measures of phase-dependent changes during these conditions were examined while subjects crossed the obstacle with their anesthetised foot as either the leading or trailing limb. Interestingly, lead limb toe trajectory was significantly affected both by deficits in visual and skin input, although the joint angle strategies differed across these sensory conditions. Subjects increased lead hip flexion with partial vision but increased hip roll with skin anesthesia relative to control. In contrast, trail limb toe trajectory was affected only by visual sensory loss. Overall visual feedback and skin input from the ankle dorsum differentially affect lead and trail limb kinematics to successfully cross an obstacle. Interestingly, it appears vision is not entirely able to compensate for reduced skin input during obstacle crossing.
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