The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis

Pal, Rohit; Teli, Ghanshyam; Matada, Gurubasavaraja Swamy Purawarga

doi:10.1016/j.ejmech.2023.115609

Cited by 6 publications

(2 citation statements)

References 77 publications

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“…These include, for example, marbofloxacin, a third-generation fluoroquinolone, and DDD853651/GSK3186899, a pyrazolopyrimidine ( Sheikh et al, 2024 ). Natural compounds such as chalcones, alkaloids, quinolines and pyridines have also been shown to be effective against these parasites ( Pal et al, 2023 ), with ursolic acid, coumarin, gallic acid and apigenin, among others, being particularly active ( Afonso et al, 2023 ). In addition, other strategies such as the combination of drugs with immunotherapy have shown encouraging results.…”

Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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“…Processes 2023, 11, 3227 2 of 18 widespread disease that causes between 20,000 and 30,000 deaths each year, making it a major health problem in endemic areas. Due to the inefficacy of current medications, the improvement of leishmaniasis treatment via the administration of drugs poses a significant challenge [4,5].…”

Section: Introductionmentioning

confidence: 99%

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Mohamed Abdoul-Latif,

Ainane,

Aboubaker

et al. 2023

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In this study, anti-leishmanial activities were performed on silver oxide nanoparticles green synthesized from hexane, ethereal, chloroform, and methanolic extracts of the Ericaria amentacea seaweed. The extracts were obtained using a soxhlet extraction system, and the silver oxide nanoparticles were synthesized through a simple and environmentally friendly method. Physicochemical characterizations, including UV spectrophotometry, transmission electron microscopy (TEM), X-ray diffraction (XRD), thermal gravimetry analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and zeta potential analysis (ZPA), were conducted to confirm the formation of silver oxide particles. The anti-leishmanial activity was evaluated in vitro using the MTT assay against the Leishmania infantum, Leishmania tropica, and Leishmania major strains. Additionally, a brine shrimp cytotoxicity test was performed on Artemia salina larvae to assess the toxicity of the products. The results showed that the anti-leishmanial activity of the synthesized silver oxide nanoparticles was significant, with inhibitory concentration values ranging from 27.16 μg/mL to 38.18 μg/mL. The lethal doses in the cytotoxicity activities were higher than 17.08 μg/mL, indicating low toxicity. These findings suggest that silver oxide nanoparticles derived from Ericaria amentacea seaweed have potential applications in the treatment of leishmaniasis. Further research is needed to elucidate the mechanisms of action and assess the in vivo efficacy of these nanoparticles. Moreover, comprehensive toxicity studies are necessary before considering their clinical use in leishmaniasis treatment.

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Synthetic product-based approach toward potential antileishmanial drug development

Pal,

Teli,

Akhtar

et al. 2024

European Journal of Medicinal Chemistry

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The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis

Cited by 6 publications

References 77 publications

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Synthetic product-based approach toward potential antileishmanial drug development

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