The role of nasal secretions in allergic disease of the nose

Bachert, Claus; Becker, W.M.; Ganzer, U.

doi:10.1007/bf00453657

Cited by 8 publications

(2 citation statements)

References 50 publications

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“…The supernatant after centrifugation (2,000 g, 10°C, 30 minutes) was used to measure the tissue-specific IgE by the same method used for serum studies. 7 Each value determined was expressed in units IU/g. Nasal scrapings E osinoPhils and basophilic cells (mast cells and basophils) in epithelium were obtained by gently scraping with a blunt ear curette the anterior part of the inferior turbinates after removal of nasal secretion by both nasal blowing and suction.…”

Section: Methodsmentioning

confidence: 99%

Antigen-Specific IgE Antibody and Cytogram in Mucosa of the Nose and Sinus

Liu

Shun²,

Song

et al. 1993

American Journal of Rhinology

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Maxillary sinus mucosa from sinusitis patients (n = 60) and nasal mucosa from the inferior turbinates ofhypertrophic rhinitis patients (n = 31) were collected to detect the appearance of tissue dust mite-specific IgE antibody and increase in eosinophils, mast cells, and plasma cells. The serum levels of total IgE and dust mite-specific IgE antibody were significantl.v greater in atopic patients than in nonatopic patients, whereas tissue specific IgE antibody was elevated in turbinate mucosa but not in sinus mucosa. Eosinophils and basophilic cells in epithelial scrapings from the inferior turbinates, assessed by Hansel stain, increased in about 85% of atopic patients with hypertrophic rhinitis (n = 16) and 60% of atopic patients with chronic sinusitis (n = 12). The increase in eosinophils, mast cells, and plasma cells was more prevalent in the turbinate mucosa of atopic patients than in that of nonatopics, but there was no such increase in sinus mucosa. We conclude that the maxillary sinuses may not be the target organ of type I allergic reaction and antigen-specific IgE antibody is probably produced by the local lymphoid tissue.Am J Rhinology W ith the improvement of nutrition and medical care, the incidence of chronic sinusitis is gradually decreasing in Taiwan. 1 However, the changed lifestyle and increasingly polluted environment have resulted in more numerous patients with respiratory tract hypersensitivity.2 Earlier studies by Savolainen 3 and van Dishoeck 4 indicate that allergic rhinitis and acute or chronic sinusitis are closely linked. They found that 30-50% of patients with acute sinusitis and 40-67% of patients with chronic sinusitis have a history of nasal allergy. Sinus X-rays reveal abnormality in 50% of nasal-allergic patients. 5 . 6 The question arises whether sinusitis is due to the effect of immediate type allergic reaction occurring in the sinus mucosa by direct contact with inhalant antigens or whether it is secondary to edematous obstruction of the sinus ostium. The purposes of our work were to investigate the role of allergy as an underlying factor in sinusitis and to analyze the relation between the histopathologic changes of sinus and turbinate mucosa and IgE production in nasal allergy. MATERIALS AND METHODSPatient population S ixty patients proved to have chronic sinusitis by the presence of mucopurulent rhinorrhea (with or without nasal polyps) and mucosal changes (mucosa thickening >5 mm or opacification) in sinus X-ray films were selected for surgical intervention. The ages were in the range of 20-50 years. They included 38 men with a mean age of 38.2 years and 22 women with a mean age of 35.5 years. Another 31 patients with 111

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Section: Methodsmentioning

confidence: 99%

Antigen-Specific IgE Antibody and Cytogram in Mucosa of the Nose and Sinus

Liu

Shun²,

Song

et al. 1993

American Journal of Rhinology

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“…The mucosal surfaces of the respiratory tract are lined by a secretory layer which contains proteins responsible for bacterial growth inhibition and prevention of microorganisms' invasion. The composition of nasal secretions varies considerably in pathological conditions such as allergic diseases and infection [7]. Collection of nasal secretions for smear evaluation can be achieved by blow-out technique, insertion of a saline nasal tampon, aspiration after stimulation with cellulose sponge, swabbing with a cotton applicator or by collection in a specimen bottle at periods of acute exacerbation [8], [9].…”

Section: Introductionmentioning

confidence: 99%

Nasal Secretion Cytology of Children Attending a Primary School in Enugu Metropolis – A Preliminary Evaluation using the Blow-out Technique

Azubuike

Ejiogu

2021

EJMED

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Nasal smear is a valid method used to distinguish inflammatory and non-inflammatory conditions. The present study was conducted to evaluate the cytological picture and neutrophilic infiltration of nasal secretions of children from a primary school within Enugu metropolis in Enugu State, Nigeria. The study included 100 apparently normal pupils, 20 each from grade levels 1 to 5. The blow-out technique was used to obtain samples from the nasal cavity for smear preparation on slides. May-Grunwald-Giemsa was used to stain the smears for light microscopical examination. Smears were assessed for the presence of infiltrating inflammatory cells and a semi-quantitative grading of neutrophilic infiltration was conducted on each sample to indicate either absent, few, moderate or many. Mean age of participants is 6.25±0.44 years (range: 6–11 years). Results revealed that age and grade level of study had a strong association with the grade score of neutrophilic infiltration (p<0.05). Grade level 1 pupils, the youngest group (mean age: 6.25±0.44 years), had the highest abnormal cytological picture and neutrophilic infiltration while those in grade levels 3 to 5 who were older, were lower. There was no association between gender and neutrophilic infiltration. It can be concluded that significantly increased neutrophilic infiltration are obtained in the nasal secretions of younger schoolchildren below the age of 9 than the older pupils. This study also indicates that the blow-out method is a useful technique for obtaining nasal secretions for the assessment of infiltrating cells.

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Moderne Funktionsdiagnostik der Nase und der Nasennebenhöhlen

Deitmer

1996

Verhandlungsbericht 1996 Der Deutschen Gesellschaft Für Hals-Nasen-Ohren-Heilkunde, Kopf- Und Hals-Chirurgie 1996

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The role of nasal secretions in allergic disease of the nose

Cited by 8 publications

References 50 publications

Antigen-Specific IgE Antibody and Cytogram in Mucosa of the Nose and Sinus

Antigen-Specific IgE Antibody and Cytogram in Mucosa of the Nose and Sinus

Nasal Secretion Cytology of Children Attending a Primary School in Enugu Metropolis – A Preliminary Evaluation using the Blow-out Technique

Moderne Funktionsdiagnostik der Nase und der Nasennebenhöhlen

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