The Role of Nanotechnology in Induced Pluripotent and Embryonic Stem Cells Research

Abstract

This paper reviews the recent studies on development of nanotechnology in the field of induced pluripotent and embryonic stem cells. Stem cell therapy is a promising therapy that can improve the quality of life for patients with refractory diseases. However, this option is limited by the scarcity of tissues, ethical problem, and tumorigenicity. Nanotechnology is another promising therapy that can be used to mimic the extracellular matrix, label the implanted cells, and also can be applied in the tissue engineering. In this review, we briefly introduce implementation of nanotechnology in induced pluripotent and embryonic stem cells research. Finally, the potential application of nanotechnology in tissue engineering and regenerative medicine is also discussed.

Polysaccharide‐Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside

“…The resulting cross‐linked NPs were obtained by self‐assembly of HA–Lys–LA conjugates with the presence of DOX and a catalytic amount of DTT. Among its applications, the broad spectrum of options for HA chemical modifications can be applied to achieve a specific targeting and long‐lasting delivery of various therapeutics, including protein, peptides, and small molecule drugs …”

Nanotechnology for mesenchymal stem cell therapies

“…Extensive studies have been published regarding the impact of nanotechnology in a broad spectrum of stem cell types, including pluripotent [47], neural [48,49], and hematopoietic [50] cells-driven tissue engineering.…”

Impact of Nanotechnology in Induced Pluripotent Stem Cells-driven Tissue Engineering and Regenerative Medicine

“…The application of nanotechnology is not only limited to tissue engineering but it can also be extended to other fields such as labeling, imaging and tracking of iPSCs, genetic modification of iPSCs and manipulating the microenvironment/niche of iPSCs. [5][6][7] Considering the aforementioned impact of nanotechnology in the field of iPSCs, in this article, the authors have focused their attention to concisely review the different types of nanomaterials, their interactions with iPSCs and to evaluate their use in combination with iPSCs suitable for various biomedical applications, which includes iPSCs-driven tissue engineering, iPSCs labeling and tracking, iPSCs generation methods, and manipulation of iPSCs microenvironment. The authors do not suggest that this is the only choice of cells available for tissue engineering and regenerative medicine, but the key intention is to stimulate research on iPSCs in the context of nanomaterial-driven tissue engineering and to evaluate their full potential, in terms of cellular growth and function, as an alternate cell source for tissue regenerative medicine.…”