The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers

Biomaterial scaffolds for clinical procedures in endodontic regeneration

“…Nanotechnology has been undergoing rapid development in science and technology and witnessed tremendous achievements in creating a wide variety of biomedical applications such as tissue regeneration, drug delivery, biosensors, antimicrobial application, gene transfection and imaging [ 220 , 221 ]. In the last two decades, nanotechnology has become a powerful tool for the design, synthetization and fabrication of advanced nanoscale biomaterials that can be harnessed for root canal disinfection, stabilization of root dentine, delivery of bioactive molecules and scaffolding for regenerative endodontics [ [157] , [158] , [159] , [220] , [221] , [222] , [223] , [224] , [225] , [226] , [227] , [228] , [229] , [230] ]. The effective elimination of bacterial biofilms is considered as the major challenge in the clinical procedures of endodontic regeneration.…”

“…Recent advances in nanotechnology have revolutionized design strategies of biomaterial scaffolds for endodontic regeneration. Nanotechnology-based design can mimic mechanical, chemical and biological properties of native tissues and promote the temporal and spatial control of various biological processes [ [228] , [229] , [230] ]. For example, a hierarchical growth factor-loaded nanofibrous PLLA microsphere scaffolding system with a highly porous injectable form was designed, synthesized and demonstrated to control the sustained release of VEGF and efficiently support the proliferation of DPSCs.…”