Nanohydroxyapatite in dentistry: A comprehensive review

Pushpalatha, C.; Gayathri, V.S.; Sowmya, S. V.; Augustine, Dominic; Alamoudi, Ahmed; Zidane, Bassam; Albar, Nassreen Hassan Mohammad; Bhandi, Shilpa

doi:10.1016/j.sdentj.2023.05.018

Cited by 8 publications

(2 citation statements)

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“…This bioactive and biocompatible material shares a similar chemical composition with the apatite crystals found in human enamel and is capable of reducing local or systemic inflammatory reactions [142][143][144]. Numerous in vitro and in situ studies have documented its remarkable remineralization, preventive capabilities in oral treatments and dental caries, reduction in dentinal hypersensitivity, and restoration of tooth deformities [145][146][147]. HAp has demonstrated a strong ability to adhere to tooth surfaces, effectively absorbing plaque components and bacteria, further supporting its potential as an effective oral care ingredient [148][149][150].…”

Section: Hydroxyapatite Nanoparticlesmentioning

confidence: 99%

Nanoparticles and Their Antibacterial Application in Endodontics

Capuano,

Amato,

Dell’Annunziata

et al. 2023

Antibiotics

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Root canal treatment represents a significant challenge as current cleaning and disinfection methodologies fail to remove persistent bacterial biofilms within the intricate anatomical structures. Recently, the field of nanotechnology has emerged as a promising frontier with numerous biomedical applications. Among the most notable contributions of nanotechnology are nanoparticles, which possess antimicrobial, antifungal, and antiviral properties. Nanoparticles cause the destructuring of bacterial walls, increasing the permeability of the cell membrane, stimulating the generation of reactive oxygen species, and interrupting the replication of deoxyribonucleic acid through the controlled release of ions. Thus, they could revolutionize endodontics, obtaining superior results and guaranteeing a promising short- and long-term prognosis. Therefore, chitosan, silver, graphene, poly(lactic) co-glycolic acid, bioactive glass, mesoporous calcium silicate, hydroxyapatite, zirconia, glucose oxidase magnetic, copper, and zinc oxide nanoparticles in endodontic therapy have been investigated in the present review. The diversified antimicrobial mechanisms of action, the numerous applications, and the high degree of clinical safety could encourage the scientific community to adopt nanoparticles as potential drugs for the treatment of endodontic diseases, overcoming the limitations related to antibiotic resistance and eradication of the biofilm.

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Section: Hydroxyapatite Nanoparticlesmentioning

confidence: 99%

Nanoparticles and Their Antibacterial Application in Endodontics

Capuano,

Amato,

Dell’Annunziata

et al. 2023

Antibiotics

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show abstract

“…The antibacterial ability of (–OH) groups also contributes to the destruction of bacterial cell walls ( Jahangir et al, 2021 ). Even though nano-HA's alkaline nature damages bacterial cell membranes and proteins, disrupting the integrity, the organic scaffold is remineralized with EGCG ( Aprilisna et al, 2015 , Pushpalatha et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%