The role of MMP genes in recurrent depressive disorders and cognitive functions

Bobińska, Kinga; Szemraj, Janusz; Gałecki, Piotr; Talarowska, Monika

doi:10.1017/neu.2015.72

Cited by 31 publications

(24 citation statements)

References 40 publications

(48 reference statements)

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“…To our knowledge, this is the first study to systematically investigate the roles of peripheral gene expression for indicators of inflammation and ox-idative balance in personality traits predisposing to a depressive episode. In our previous papers we referred to oxidative and antioxidative imbalances and immune system disorders in patients with symptoms of depression and among healthy people: MnSOD [24], MPO [25], COX-2 [26], iNOS [27], MMP-2 and MMP-9 [28]. At this point, we would like to summarise the correlations related to the functioning of the immune and emotional systems.…”

Section: Discussionmentioning

confidence: 99%

Immune to happiness – inflammatory process indicators and depressive personality traits

Talarowska¹,

Kowalczyk²,

Maes³

et al. 2020

aoms

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Introduction: Nowadays, depression is conceptualized as an immune-inflammatory and oxidative stress disorder associated with neuroprogressive changes as a consequence of peripherally activated immune-inflammatory pathways, including peripheral cytokines and immune cells which penetrate into the brain via the blood barrier, as well as nitro-oxidative stress and antioxidant imbalances. The aim of this study was to investigate whether personality traits predisposing to a depressive episode (hypochondria, dysthymic, hysteria) are associated with changes in peripheral gene expression for selected indicators of inflammation and oxidative balance. Material and methods: One hundred four people meeting the diagnostic criteria specified for a depressive episode took part in the study. Selected scales of the Minnesota Multiphasic Personality Inventory (MMPI-2) were used to measure personality traits. Expression at the mRNA and protein level for manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), and metalloproteinases 2 and 9 (MMP-2, MMP-9) was examined. Results: Scales for the neurotic triad of the MMPI-2 test correlated significantly with the expression at the level of mRNA and protein for MnSOD, MPO and metalloproteinases 2 and 9. Conclusions: The scales specified for the neurotic triad of the MMPI-2 test correspond substantially with the expression of MnSOD, MPO and metalloproteinases 2 and 9 at the mRNA and protein levels in the group of patients suffering from depression.

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Section: Discussionmentioning

confidence: 99%

Immune to happiness – inflammatory process indicators and depressive personality traits

Talarowska¹,

Kowalczyk²,

Maes³

et al. 2020

aoms

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“…Regarding protein biomarker candidates, we identified 37 plasma proteins significantly associated with MDD by the LMM analysis, and these protein biomarkers could be biologically or physiologically divided into four functional categories through the literature search on PubTabor central [40]. First, six plasma markers, GC, LCN2, ITIH3, VWF, PHOX2B and YWHAE, were previously reported to be associated with SSRI efficacy, with the abundances of GC, LCN2, and ITIH3 in plasma samples associated with response to SSRIs [21,[53][54][55]. Among them, PHOX2B and YWHAE were validated by LC-MRM/MS analysis in this study.…”

Section: Discussionmentioning

confidence: 99%

“…We found that the levels of abundance of two of these proteins, APOE and CSTD, with single nucleotide polymorphisms (SNPs) differed significantly in responders and non-responders [75][76][77][78]. The expression of the MMP2 gene in the brain was associated with recurrence of depression [55].…”

Section: Discussionmentioning

confidence: 99%

An Exploratory Pilot Study with Plasma Protein Signatures Associated with Response of Patients with Depression to Antidepressant Treatment for 10 Weeks

et al. 2020

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Major depressive disorder (MDD) is a leading cause of global disability with a chronic and recurrent course. Recognition of biological markers that could predict and monitor response to drug treatment could personalize clinical decision-making, minimize unnecessary drug exposure, and achieve better outcomes. Four longitudinal plasma samples were collected from each of ten patients with MDD treated with antidepressants for 10 weeks. Plasma proteins were analyzed qualitatively and quantitatively with a nanoflow LC−MS/MS technique. Of 1153 proteins identified in the 40 longitudinal plasma samples, 37 proteins were significantly associated with response/time and clustered into six according to time and response by the linear mixed model. Among them, three early-drug response markers (PHOX2B, SH3BGRL3, and YWHAE) detectable within one week were verified by liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS) in the well-controlled 24 patients. In addition, 11 proteins correlated significantly with two or more psychiatric measurement indices. This pilot study might be useful in finding protein marker candidates that can monitor response to antidepressant treatment during follow-up visits within 10 weeks after the baseline visit.

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“…While there is little known about the direct role of Timp2 in learning and memory, the extracellular matrix maintains direct contact with synapses and is known to influence dendritic spine stability and synapse structure [38]. In addition, it is reduced in patients with recurrent depressive symptoms [39]. The potential connection to depressive symptoms is interesting given the downregulation observed in our PTSD-like phenotype (SS mice) and the high comorbidity between PTSD and major depressive disorder in patients [40].…”

Section: Discussionmentioning

confidence: 99%

microRNA mir-598-3p mediates susceptibility to stress-enhancement of remote fear memory

Jones

Sillivan

Jamieson

et al. 2019

Preprint

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Number of words in abstract: 214Number of words in main text: 5,913Running title: BLA mir-598-3p supports stress-enhanced memory ABSTRACT microRNAs (miRNAs) have emerged as potent regulators of learning, recent memory and extinction. However, our understanding of miRNAs directly involved in regulating complex psychiatric conditions perpetuated by aberrant memory, such as in posttraumatic stress disorder (PTSD), remains limited. To begin to address the role of miRNAs in persistent memory, we performed small-RNA sequencing on basolateral amygdala (BLA) tissue to identify miRNAs altered by auditory fear conditioning (FC) one month after training. mir-598-3p, a highly conserved miRNA previously unstudied in the brain, was downregulated in the BLA. Further decreasing BLA mir-598-3p levels did not alter the expression or extinction of the remote fear memory. Given that stress is a critical component in PTSD, we next assessed the impact of stress-enhanced fear learning (SEFL) on mir-598-3p levels, finding the miRNA is elevated in the BLA of male, but not female, mice susceptible to the effects of stress in SEFL. Accordingly, intra-BLA inhibition of mir-598-3p interfered with expression and extinction of the remote fear memory in male, but not female, mice. This effect could not be attributed to an anxiolytic effect of miRNA inhibition. Finally, bioinformatic analysis following quantitative proteomics on BLA tissue collected 30 days post-SEFL training identified putative mir-598-3p targets and related pathways mediating the differential susceptibility, with evidence for regulation of the actin cytoskeleton.

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The role of MMP genes in recurrent depressive disorders and cognitive functions

Cited by 31 publications

References 40 publications

Immune to happiness – inflammatory process indicators and depressive personality traits

Immune to happiness – inflammatory process indicators and depressive personality traits

An Exploratory Pilot Study with Plasma Protein Signatures Associated with Response of Patients with Depression to Antidepressant Treatment for 10 Weeks

microRNA mir-598-3p mediates susceptibility to stress-enhancement of remote fear memory

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