The role of Mitogen activated protein kinase (MAPK) in sperm functions

Almog, Tal; Naor, Zvi

doi:10.1016/j.mce.2009.05.009

Cited by 64 publications

(56 citation statements)

References 44 publications

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“…In addition, many cell-autonomous events in the developing germ cells require intracellular signalling (Grootegoed et al, 2000;Ruwanpura et al, 2010;Jan et al, 2012). In view of the overwhelming evidence for the role of many different protein kinases in inter and intracellular signalling events in virtually all types of cells and tissues (Johnson, 2009a), it is not surprising that a number of protein kinases are involved in various aspects of spermatogenesis (Li et al, 2009;Lie et al, 2009;Almog & Naor, 2010;Luconi et al, 2011;Tang et al, 2012). Studying the properties, activities and evolution of testicular kinases is relevant, not only in relation to basic knowledge about spermatogenesis but also to advance our understanding of infertility.…”

Section: Introductionmentioning

confidence: 99%

Evolution of testis‐specific kinases TSSK1B and TSSK2 in primates

et al. 2012

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SUMMARYThe testis-specific serine/threonine protein kinases TSSK1 and TSSK2 are known to be essential for male fertility, in mice. The enzymes are present in elongating spermatids, and targeted deletion of the two genes Tssk1 and Tssk2 results in dysregulation of spermiogenesis. The mouse genes are genetically closely linked, forming a Tssk1-Tssk2 tandem. In human, TSSK1 is present in the form of a pseudogene, TSSK1A, which is linked to an intact TSSK2 gene, and in the form of an intact gene, TSSK1B, which is not genetically linked to TSSK2. Studies on conservation of genes and gene function between mouse and human are relevant, to be able to use mouse models for studies on human infertility, and to evaluate possible targets for non-hormonal contraception targeting the male. Therefore, we have performed a detailed analysis of the evolution of genes encoding TSSK1 and TSSK2 among mammals, in particular among primates. This study includes functional analysis of replacement mutation K27R in TSSK2, which is frequently observed among humans. In primates, the kinase domains of TSSK1B and TSSK2 have evolved under negative selection, reflecting the importance to maintain their kinase activity. Positive selection was observed for the C-terminal domain of TSSK1B, which indicates that TSSK1B and TSSK2 may perform at least partly differential functions.

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Section: Introductionmentioning

confidence: 99%

Evolution of testis‐specific kinases TSSK1B and TSSK2 in primates

et al. 2012

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“…Its functions in male reproduction, such as the regulation of spermatogenic cell proliferation and androgen secretion in mouse testis, attracted our attention (Jiang et al, 2003). P38 has also been detected at the post-acrosomal region of human sperm and found to be sporadically distributed on the sperm tail, serving as a negative regulator of sperm motility (Almog and Naor, 2010).…”

Section: Discussionmentioning

confidence: 99%

P38 participates in spermatogenesis and acrosome reaction prior to fertilization in Chinese mitten crab Eriocheir sinensis

Zhu

Sun

Wang

et al. 2015

Gene

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“…Several protein kinases have been shown to be involved in spermatogenesis (22), 4.7% protein kinases in the mouse testis strongly suggested that more active catalytic activity was performed in the testis. It is worth mentioning that 44 proteins have serine/threonine protein kinase-related domain, which may function to link the pathway of cell signaling, cell cycle related to spermatogenesis (23).…”

Section: Discussionmentioning

confidence: 99%