The role of mitofilin in left ventricular hypertrophy in hemodialysis patients

He, Qiang; He, Jiekun; Chen, Jun; Wang, Wenyan; Zhou, Yan; Lou, Ji-Zhuang; Kong, Wei Yen; Chen, Junfeng

doi:10.1080/0886022x.2018.1456455

Cited by 13 publications

(9 citation statements)

References 20 publications

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“…Left ventricular mass is strongly related to efficacy of glucose and fatty acid oxidation by the mitochondria. 44 Mitochondrial DNA is inherited through the mother, which might explain why previous studies presented stronger motheroffspring left ventricular mass associations than father-offspring associations. 45 This is the first study to examine the association between parent-offspring fractional shortening.…”

Section: Discussionmentioning

confidence: 98%

52. Cardiovascular risk factors track from mother to child

Benschop

Schalekamp‐Timmermans

Lennep

et al. 2018

Pregnancy Hypertension

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Background--Cardiovascular risk factors can track from mother to child by several pathways: pregnancy complications, genetic inheritance, and shared environmental risk factors after pregnancy. The degree of tracking, and to which extent this is influenced by these pathways, is unknown. We hypothesized that cardiovascular risk factors track from mother to child regardless of pregnancy complications and environmental risk factors. We determined the degree of tracking between maternal and offspring micro-and macrovascular cardiovascular risk factors after pregnancy and the extent to which this is influenced by pregnancy complications and shared environmental risk factors.Methods and Results--We included 5624 mother-offspring pairs from The Generation R Study, an ongoing prospective, population-based birth cohort. Information on pregnancy complications (preeclampsia, small for gestational age, and preterm birth) was obtained through hospital charts. Mother-offspring associations were assessed 6 years after pregnancy (central retinal arteriolar and venular calibers, body mass index, blood pressure, left atrial diameter, aortic root diameter, left ventricular mass, fractional shortening, and pulse wave velocity) and 9 years after pregnancy (body mass index and blood pressure). We observed that worse cardiovascular parameters in mothers were associated with worse cardiovascular parameters in their offspring 6 and 9 years after pregnancy (P<0.001). Results were similar when mother-offspring pairs with a previous pregnancy complication were excluded.Conclusions--Six and 9 years after pregnancy, an adverse cardiovascular profile in mothers is strongly associated with an adverse cardiovascular profile in their offspring. Results were not attenuated by environmental exposures or a previous pregnancy complication. This supports the hypothesis that cardiovascular risk factors (micro-and macrovascular) track from mother to child, regardless of the course of pregnancy.

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Section: Discussionmentioning

confidence: 98%

52. Cardiovascular risk factors track from mother to child

Benschop

Schalekamp‐Timmermans

Lennep

et al. 2018

Pregnancy Hypertension

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“…The baseline clinical data of patients were collected, including gender, age, height and weight, and the body mass index (BMI) was calculated according to the following formula: BMI = weight (kg)/ [height (cm)] 2 . DBP and SBP of the patients measured by nurses in our hospital at admission were collected.…”

Section: Methodsmentioning

confidence: 99%

“…At present, its pathophysiological mechanism has not been fully clarified, but miRNAs have been verified to participate in cardiovascular pathophysiological processes such as heart development and remodeling, arrhythmia and myocardial hypertrophy. 2 Circulating miRNAs, i.e. miRNAs in serum and plasma, can maintain extremely high stability under harsh conditions such as high temperature, acidity and alkalinity together with RNase .…”

Section: Introductionmentioning

confidence: 99%

Correlations of circulating miR-26b level with left ventricular hypertrophy and cardiac function in elderly patients with hypertension

Fu¹,

Lin

Pan

et al. 2021

Pak J Med Sci

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Objectives: To study the correlations of circulating miR-26b level with left ventricular hypertrophy (LVH) and cardiac function in elderly patients with hypertension. Methods: A total of 132 eligible patients were divided into low and high miR-26b level groups. Their baseline clinical data and biochemical indices were compared. The correlations between miR-26b level and echocardiographic parameters were studied by Pearson’s analysis. Factors affecting LVH were explored by multivariate logistic regression analysis. The role of miR-26b in diagnosing LVH was predicted by receiver operating characteristic curve. Results: The relative expression level of miR-26b was 4.56-16.93, with a median of 7.62. The two groups had similar baseline clinical data and biochemical indices (P>0.05). Compared with high miR-26b level group, interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI) and number of LVH cases in low miR-26b level group significantly increased (P<0.05), and mitral ratio of peak early to late diastolic filling velocity (E/A) decreased (P<0.05). Circulating miR-26b level was negatively correlated with IVST, LVPWT and LVMI (P<0.0001), and positively correlated with E/A (P<0.0001). The proportion of cardiac hypofunction cases in low miR-26b level group significantly exceeded that of high miR-26b level group (P<0.05). Age and increased IVST, LVPWT and LVMI were independent risk factors for LVH (P<0.05), and elevated miR-26b level was a protective factor (P<0.05). AUC was 0.836, and the optimal cutoff value was 8.83, with high sensitivity and specificity. Conclusions: MiR-26b level is negatively correlated with LVH and positively correlated with left ventricular diastolic function in elderly hypertensive patients. It is a protective factor for LVH complicated with diastolic dysfunction and a potential biomarker for diagnosis. doi: https://doi.org/10.12669/pjms.37.4.4048 How to cite this:Fu J, Lin F, Pan Z, Wu C. Correlations of circulating miR-26b level with left ventricular hypertrophy and cardiac function in elderly patients with hypertension. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.4048 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Remarkably, this MA‐5‐Mic60 effect yielded to increase mitochondrial ATP production and reduce ROS production, but without affecting respiratory chain activity or the respiratory complexes themselves (Suzuki et al, ). Adding to the necessity of Mic60 in normal kidney function, Wu et al () found in humans that, patients with hemodialysis had significantly less Mic60 expression compared with healthy volunteers, with the Mic60 expression decreasing even more in patients with kidney dialysis with heart left ventricle hypertrophy. These observations indicate that Mic60 may represent an important therapeutic target in kidney disease.…”

Section: Mic60 In the Kidneymentioning

confidence: 99%

Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protection

Feng

Madungwe

Bopassa

2018

Journal Cellular Physiology

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The identification of the mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane shed light on the intricate components necessary for mitochondria to form their signature cristae in which many protein complexes including the electron transport chain are localized. Mic60/mitofilin has been described as the core component for the assembly and maintenance of MICOS, thus controlling cristae morphology, protein transport, mitochondrial DNA transcription, as well as connecting the inner and outer mitochondrial membranes. Although Mic60 homologs are present in many species, mammalian Mic60 is only recently gaining attention as a critical player in several organ systems and diseases with mitochondrial-defect origins. In this review, we summarize what is currently known about the ever-expanding role of Mic60 in mammals, and highlight some new studies pushing the field of mitochondrial cristae organization towards potentially new and exciting therapies targeting this protein.

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The role of mitofilin in left ventricular hypertrophy in hemodialysis patients

Cited by 13 publications

References 20 publications

52. Cardiovascular risk factors track from mother to child

52. Cardiovascular risk factors track from mother to child

Correlations of circulating miR-26b level with left ventricular hypertrophy and cardiac function in elderly patients with hypertension

Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protection

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